Results 61 to 70 of about 23,000 (243)

Inducible and reversible RNA N6-methyladenosine editing

Nature Communications, 2022
RNA modifications, including N6-methyladenosine (m6A), have been reported to regulate fundamental RNA processes and properties, and directly linked to various human diseases.
Huaxia Shi, Ying Xu, Na Tian, Ming Yang, Fu-Sen Liang   +4 more
doaj   +1 more source

Transcriptome-wide high-throughput deep m6A-seq reveals unique differential m6A methylation patterns between three organs in Arabidopsis thaliana [PDF]

, 2015
Proportion of two types of m6A distributing feature in mRNA.
Dayong Zhang, Kai Tang, Shaojun Xie, Xiaohong Zhu, Yizhen Wan, Zegang Wang, Zhaobo Lang   +6 more
core   +11 more sources

An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis

Nature Communications, 2020
The involvement of long non-coding RNA (lncRNA) in the regulation of N6-methyladenosine (m6A) modification of RNA is unclear. Here, the authors show that LINC00266-1 encodes a peptide that binds to m6A reader, IGF2BP1 to enhance the recognition of m6A ...
Song Zhu, Ji-Zhong Wang, De Chen, Yu-Tian He, Nan Meng, Min Chen, Rui-Xun Lu, Xin-Hui Chen, Xiao-Lan Zhang, Guang-Rong Yan   +9 more
doaj   +1 more source

The emerging roles and mechanism of N6-methyladenosine (m6A) modifications in urologic tumours progression

Frontiers in Pharmacology, 2023
Prostate cancer (PCa), bladder cancer (BC), and renal cell cancer (RCC) are the most common urologic tumours in males. N6-methyladenosine (m6A), adenosine N6 methylation, is the most prevalent RNA modification in mammals.
Wenhao Zhu, Renshan Zhao, Xiaomin Guan, Xu Wang   +3 more
doaj   +1 more source

Effect of methylation of adenine N6 on kink turn structure depends on location [PDF]

, 2019
N6-methyladenine is the most common covalent modification in cellular RNA species, with demonstrated functional consequences. At the molecular level this methylation could alter local RNA structure, and/or modulate the binding of specific proteins.
Bokar JA, David M. J. Lilley, Lin Huang, Saira Ashraf   +3 more
core   +2 more sources

Emerging roles of N6-methyladenosine (m6A) modification in breast cancer [PDF]

Cell & Bioscience, 2020
AbstractN6-Methyladenosine (m6A) is the most abundant, dynamic, and reversible epigenetic RNA modification that is found in coding and non-coding RNAs. Emerging studies have shown that m6A and its regulators affect multiple steps in RNA metabolism and play broad roles in various cancers.
Yanyan Wang, Yujie Zhang, Yushen Du, Meiqi Zhou, Yue Hu, Suzhan Zhang   +5 more
openaire   +2 more sources

Parallel functional assessment of m6A sites in human endodermal differentiation with base editor screens

Nature Communications, 2022
N6-methyladenosine (m6A) plays important role in lineage specifications of embryonic stem cells, but its role at specific sites has not been assessed. Here the authors develop an adenine editor-based strategy, and systematically identify functional m6A ...
Weisheng Cheng, Fang Liu, Zhijun Ren, Wenfang Chen, Yaxin Chen, Tianwei Liu, Yixin Ma, Nan Cao, Jinkai Wang   +8 more
doaj   +1 more source

m^6A RNA methylation promotes XIST-mediated transcriptional repression [PDF]

, 2016
The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly methylated with at least 78 N^6-methyladenosine (m^6A) residues—a ...
A Minajigi, A Wutz, A Wutz, AJ Link, AM Hartmann, Amy Chow, B Linder, B Moindrot, Brian F. Pickering, C Chu, CA McHugh, Chun-Kan Chen, CM Wei, Constanza Jackson, CR Alarcón, D Dominissini, Deepak P. Patil, F Ramírez, FL Wilkinson, G Jia, G Singh, GD Penny, H Uranishi, I Huppertz, J Kochan, J König, J Schindelin, J Zhao, JA Bokar, JM Engreitz, K Horiuchi, K Morohashi, K Plath, KD Meyer, KD Meyer, KD Meyer, L Berglund, L Bylund, Mitchell Guttman, MJ Cowley, N Liu, P Shannon, Q Cao, S Geula, S Heinz, S Niranjanakumari, S Schwartz, S Zhong, Samie R. Jaffrey, SC Kwon, SD Agarwala, SM Weyn-Vanhentenryck, W Ma, W Xiao, X Wang, X Wang, XL Ping, Y Hasegawa, YC Lin   +58 more
core   +2 more sources

BGN/MDK Axis in the Melanoma Tumor Microenvironment Strengthens Tumor Malignancy by Modulating Cancer Cells and Cancer‐Associated Fibroblasts Crosstalk

Advanced Science, EarlyView.
This study reveals that m6A regulators cooperatively upregulate BGN in melanoma, promoting malignancy. Within the tumor microenvironment, CAFs show highest BGN expression. The BGN/MDK axis mediates cancer‐stroma crosstalk, driving normal fibroblast (NF) activation and enhancing the pro‐tumor effect of CAFs, highlighting a promising therapeutic target ...
Hao‐ze Shi, Ming‐yang Wu, Jin‐quan Liu, Cuicui Tian, Li Ma, Xue‐mei Zhou, Ze‐Hao Sun, Zhi‐yong Xu, Run‐dong Zhang, Shan‐yuan Ye, Li‐ming Huang, Yan Wang, Jing‐shu Xiong, Wen‐bo Bu, Xian‐feng Cheng, Jian‐fang Sun, Hao Chen   +16 more
wiley   +1 more source

Emerging Perspectives of RNA N6-methyladenosine (m6A) Modification on Immunity and Autoimmune Diseases

Frontiers in Immunology, 2021
N6-methyladenosine (m6A) modification, the addition of a methylation decoration at the position of N6 of adenosine, is one of the most prevalent modifications among the over 100 known chemical modifications of RNA.
Lipeng Tang, Xingyan Wei, Tong Li, Tong Li, Yi Chen, Zhenhua Dai, Chuanjian Lu, Guangjuan Zheng, Guangjuan Zheng   +8 more
doaj   +1 more source