Results 31 to 40 of about 23,000 (243)
m6a RNA methylation: the implications for health and disease [PDF]
, 2014 The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification.
McGuinness, D., Mcguinness, D.H.
core +1 more source
Insights into N6-methyladenosine (m6A) modification of noncoding RNA in tumor microenvironment. [PDF]
Aging (Albany NY), 2023 N6-methyladenosine (m6A) is the most abundant RNA modification in eukaryotes, and it participates in the regulation of pathophysiological processes in various diseases, including malignant tumors, by regulating the expression and function of both coding and non-coding RNAs (ncRNAs). More and more studies demonstrated that m6A modification regulates the
Zhang Y, Zhan L, Li J, Jiang X, Yin L.
europepmc +3 more sources
N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development
Acta Pharmaceutica Sinica B, 2018 N6-Methyladenosine (m6A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6A modification methyltransferase, demethylase and proteins that preferentially recognize m6A modification as “writers”,
Yi Niu +4 more
doaj +1 more source
BMC Molecular and Cell Biology, 2022 Background Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown.
Jie Gao +4 more
doaj +1 more source
STAR Protocols, 2022 Summary: We describe here a metabolic labeling protocol for detecting cellular transcriptome-wide mRNA N6-methyladenosine (m6A) at base resolution.
Xiao Shu, Jie Cao, Jianzhao Liu
doaj +1 more source
A neural m6A/Ythdf pathway is required for learning and memory in Drosophila
Nature Communications, 2021 Epitranscriptomic modifications can regulate learning and memory. Here, the authors provide proteomic and functional analysis of N6-methyladenosine (m6A)-binding proteins in D.
Lijuan Kan +7 more
doaj +1 more source
METTL3 regulates WTAP protein homeostasis [PDF]
, 2018 The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Capuano, Ernestina +8 more
core +2 more sources
Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer
Cancer Biology & Medicine, 2020 The biological roles of N6 methylation of nucleic acids have been extensively studied. Adenine methylation of RNA is the most prevalent RNA modification and has widespread effects on RNA splicing, translation, localization, and stability.
Zhixian Liang +3 more
doaj +1 more source
Deciphering the epitranscriptome: a green perspective [PDF]
, 2016 The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation - the epitranscriptome.
Burgess, A., David, R., Searle, I.
core +1 more source
Structural and Virus Regulatory Insights Into Avian N6-Methyladenosine (m6A) Machinery [PDF]
Frontiers in Cell and Developmental Biology, 2020 The addition of a methyl group to the N6 position of adenosine (m6A) is the most common posttranscriptional RNA modification, and it regulates most steps of RNA metabolism including splicing, stability, translation, nuclear-export, and RNA structures. Besides cellular RNA, m6A modifications have also been detected on viral RNA.
Bayoumi, Mahmoud +2 more
openaire +3 more sources