Results 31 to 40 of about 54,300 (231)

Acetaminophen changes the RNA m6A levels and m6A-related proteins expression in IL-1β-treated chondrocyte cells

BMC Molecular and Cell Biology, 2022
Background Acetaminophen is commonly recommended for the early analgesia of osteoarthritis. However, the molecular mechanism by which it acts remains unknown.
Jie Gao, Yan Li, Zijin Liu, Dong Wang, Huawu Zhang   +4 more
doaj   +1 more source

Table_4_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.XLSX

, 2021
The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439), Yue Shi (128342), Weimin Ci (4459504), Yanliang Dou (11472436), Yu Xiao (150812), Mingxin Zhang (4898947), Jie Qi (53195), Jianye Zhang (430972)   +7 more
core   +1 more source

Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer

Cancer Biology & Medicine, 2020
The biological roles of N6 methylation of nucleic acids have been extensively studied. Adenine methylation of RNA is the most prevalent RNA modification and has widespread effects on RNA splicing, translation, localization, and stability.
Zhixian Liang, Reilly L. Kidwell, Haijing Deng, Qi Xie   +3 more
doaj   +1 more source

m6A-label-seq: A metabolic labeling protocol to detect transcriptome-wide mRNA N6-methyladenosine (m6A) at base resolution

STAR Protocols, 2022
Summary: We describe here a metabolic labeling protocol for detecting cellular transcriptome-wide mRNA N6-methyladenosine (m6A) at base resolution.
Xiao Shu, Jie Cao, Jianzhao Liu
doaj   +1 more source

Data_Sheet_1_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.docx

, 2021
The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439), Yue Shi (128342), Weimin Ci (4459504), Yanliang Dou (11472436), Yu Xiao (150812), Mingxin Zhang (4898947), Jie Qi (53195), Jianye Zhang (430972)   +7 more
core   +1 more source

N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast.

, 2022
N6-methyladenosine (m6A) RNA modification impacts mRNA fate primarily via reader proteins, which dictate processes in development, stress, and disease. Yet little is known about m6A function in Saccharomyces cerevisiae, which occurs solely during early ...
Raghu R Edupuganti (14263961), Imke Ensinck (14263964), Michiel Vermeulen (131210), Theodora Sideri (41320), Zornitsa Manova (14263958), Ambrosius P Snijders (8119406), Radhika A Varier (14263955), Charlotte Capitanchik (5577323), Folkert J van Werven (8136972), Harshil Patel (195954), Alice Rossi (365502), Enrica Calvani (8265732), Vincent WC Chan (14263967), Peter Faull (9166058), Joanna Kirkpatrick (5581700), Markus Ralser (46782), Nicholas M Luscombe (8114756), Jernej Ule (115588)   +17 more
core   +1 more source

Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing

Nature Communications, 2020
Adenovirus transcripts contain N6-methyladenosine (m6A) modification. Here the authors profile m6A modification sites on adenovirus mRNAs using Illumina meRIP-Seq and nanopore direct RNA sequencing, and showcase a role for m6A in splicing of viral late ...
Alexander M. Price, Katharina E. Hayer, Alexa B. R. McIntyre, Nandan S. Gokhale, Jonathan S. Abebe, Ashley N. Della Fera, Christopher E. Mason, Stacy M. Horner, Angus C. Wilson, Daniel P. Depledge, Matthew D. Weitzman   +10 more
doaj   +1 more source

Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer

Frontiers in Medicine, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Jingchao Liu, Jingchao Liu, Jianlong Wang, Meng Wu, Wei Zhang, Wei Zhang, Lingfeng Meng, Lingfeng Meng, Jiawen Wang, Jiawen Wang, Zhengtong Lv, Zhengtong Lv, Haoran Xia, Haoran Xia, Yaoguang Zhang, Yaoguang Zhang, Jianye Wang, Jianye Wang   +17 more
doaj   +1 more source

Table_5_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.XLSX

, 2021
The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439), Yue Shi (128342), Weimin Ci (4459504), Yanliang Dou (11472436), Yu Xiao (150812), Mingxin Zhang (4898947), Jie Qi (53195), Jianye Zhang (430972)   +7 more
core   +1 more source

Table_3_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.XLSX

, 2021
The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439), Yue Shi (128342), Weimin Ci (4459504), Yanliang Dou (11472436), Yu Xiao (150812), Mingxin Zhang (4898947), Jie Qi (53195), Jianye Zhang (430972)   +7 more
core   +1 more source