Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation [PDF]
, 2017 Transcription and translation are two main pillars of gene expression. Due to the different timings, spots of action, and mechanisms of regulation, these processes are mainly regarded as distinct and generally uncoupled, despite serving a common purpose.
Agami, R. (Reuven) +6 more
core +4 more sources
Redox BiologyElevated lactate levels are a significant biomarker of sepsis and are positively associated with sepsis-related mortality. Sepsis-associated lung injury (ALI) is a leading cause of poor prognosis in clinical patients.
Dan Wu +4 more
semanticscholar +1 more source
Genes and Diseases, 2023 N6-methyladenosine (m6A) is the most abundant internal modification on RNA. It is a dynamical and reversible process, which is regulated by m6A methyltransferase and m6A demethylase.
Cong Huang +7 more
doaj +1 more source
Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168 [PDF]
, 2016 Phase-variable restriction-modification systems are a feature of a diverse range of bacterial species. Stochastic, reversible switches in expression of the methyltransferase produces variation in methylation of specific sequences.
Awais Anjum +13 more
core +2 more sources
WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration
Nature Communications, 2022 N6-methyladenosine (m6A) is the most prevalent RNA modification at the posttranscriptional level and involved in various diseases and cellular processes.
Gaocai Li +14 more
semanticscholar +1 more source
The m6A Methyltransferase METTL3 Is Functionally Implicated in DLBCL Development by Regulating m6A Modification in PEDF [PDF]
Frontiers in Genetics, 2020 Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of lymphoma, whose treatment still has a major challenge of achieving a satisfactory curative effect. The underlying mechanisms also have not been fully illustrated. N 6-Methyladenosine (m6A) has been identified as the most prevalent internal modification of mRNAs present in eukaryotes ...
Yingying Cheng +3 more
openaire +3 more sources
Molecular Cancer, 2022 The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of therapeutic resistance may provide new strategies for overcoming cancer ...
Hong Lin +4 more
semanticscholar +1 more source
Role of non-coding RNAs in the transgenerational epigenetic transmission of the effects of reprotoxicants [PDF]
, 2016 13 p.-1 fig.Non-coding RNAs (ncRNAs) are regulatory elements of gene expression and chromatin structure. Both long and small ncRNAs can also act as inductors and targets of epigenetic programs.
Del Mazo, Jesús, Larriba, E.
core +2 more sources
RNA m6A modification, signals for degradation or stabilisation?
Biochemical Society TransactionsThe RNA modification N6-methyladenosine (m6A) is conserved across eukaryotes, and profoundly influences RNA metabolism, including regulating RNA stability. METTL3 and METTL14, together with several accessory components, form a ‘writer’ complex catalysing
Guifeng Wei
semanticscholar +1 more source
METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability
Nucleic Acids Research, 2022 Telomeric repeat-containing RNA (TERRA) is a type of long non-coding RNA transcribed from telomeres, and it forms R-loops by invasion into telomeric DNA.
Liping Chen +5 more
semanticscholar +1 more source