Results 1 to 10 of about 199,448 (169)

Chemotherapy and the somatic mutation burden of sperm [PDF]

JCI Insight
Many chemotherapeutic agents impair cancer growth by inducing DNA damage. The impact of these agents on mutagenesis in normal cells, including sperm, is largely unknown.
Shany Picciotto, Camilo Arenas-Gallo, Amos Toren, Ruty Mehrian-Shai, Bryan Daly, Stephen Rhodes, Megan Prunty, Ruolin Liu, Anyull Bohorquez, Marta Grońska-Pęski, Shana Melanaphy, Pamela Callum, Emilie Lassen, Anne-Bine Skytte, Rebecca C. Obeng, Christopher Barbieri, Molly Gallogly, Brenda Cooper, Katherine Daunov, Lydia Beard, Koen van Besien, Joshua Halpern, Quintin Pan, Gilad D. Evrony, Viktor A. Adalsteinsson, Jonathan E. Shoag   +25 more
doaj   +2 more sources

Research progress of neoantigen-based dendritic cell vaccines in pancreatic cancer

Frontiers in Immunology, 2023
The mutation of the crucial genes such as tumor suppressors or oncogenes plays an important role in the initiation and development of tumors. The non-synonymous mutations in the tumor cell genome will produce non-autologous proteins (neoantigen) to ...
Xin Zhang, Zheng Xu, Xiangpeng Dai, Xiangpeng Dai, Xiaoling Zhang, Xiaoling Zhang, Xueju Wang   +6 more
doaj   +1 more source

Molecular Characterization of the Clinical and Tumor Immune Microenvironment Signature of 5-methylcytosine-Related Regulators in non-small Cell Lung Cancer

Frontiers in Cell and Developmental Biology, 2021
Background: DNA methylation is an important epigenetic modification, among which 5-methylcytosine methylation (5mC) is generally associated with tumorigenesis.
Taisheng Liu, Liyi Guo, Guihong Liu, Xiaoshan Hu, Xiaoning Li, Jinye Zhang, Zili Dai, Peng Yu, Ming Jiang, Jian Wang, Jian Zhang   +10 more
doaj   +1 more source

Age-related somatic mutation burden in human tissues

Frontiers in Aging, 2022
The genome of multicellular organisms carries the hereditary information necessary for the development of all organs and tissues and to maintain function in adulthood.
Peijun Ren, Xiao Dong, Jan Vijg, Jan Vijg   +3 more
doaj   +1 more source

Precise Identification of Recurrent Somatic Mutations in Oral Cancer Through Whole-Exome Sequencing Using Multiple Mutation Calling Pipelines

Frontiers in Oncology, 2021
Understanding the genomic alterations in oral carcinogenesis remains crucial for the appropriate diagnosis and treatment of oral squamous cell carcinoma (OSCC).
Li-Han Lin, Chung-Hsien Chou, Hui-Wen Cheng, Kuo-Wei Chang, Kuo-Wei Chang, Chung-Ji Liu, Chung-Ji Liu   +6 more
doaj   +1 more source

Characterization of m6A regulator‐mediated methylation modification patterns and tumor microenvironment infiltration in acute myeloid leukemia

Cancer Medicine, 2022
Background Previous studies have confirmed the existence of epigenetic regulation of immune responses in acute myeloid leukemia. However, the potential role of RNA N6‐methyladenosine (m6A) remodeling in tumor microenvironment (TME) infiltration remains ...
Shiyu Han, Jiaqian Qi, Kun Fang, Hong Wang, Yaqiong Tang, Depei Wu, Yue Han   +6 more
doaj   +1 more source

The miRNA Profile of Inflammatory Colorectal Tumors Identify TGF-β as a Companion Target for Checkpoint Blockade Immunotherapy

Frontiers in Cell and Developmental Biology, 2021
Extrinsic factors such as expression of PD-L1 (programmed dealth-ligand 1) in the tumor microenvironment (TME) have been shown to correlate with responses to checkpoint blockade therapy.
Bjarne Bartlett, Bjarne Bartlett, Zitong Gao, Zitong Gao, Monique Schukking, Monique Schukking, Mark Menor, Vedbar S. Khadka, Muller Fabbri, Peiwen Fei, Youping Deng, Youping Deng   +11 more
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A Comparison of Bone Marrow Morphology and Peripheral Blood Findings in Low and High Level JAK2 V617F Allele Burden

Diagnostics, 2023
Cases with low level JAK2 V617F mutations are increasingly detected; however, the clinical interpretation of the low allele JAK2 burden may be challenging.
Emina Babarović, Blažen Marijić, Luka Vranić, Josipa Ban, Toni Valković, Ita Hadžisejdić   +5 more
doaj   +1 more source

m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia

Frontiers in Immunology, 2021
Recent studies have demonstrated epigenetic regulation of immune responses. Nevertheless, the underlying effect of RNA N6-methyladenosine (m6A) modifications on tumor microenvironment cell infiltration remains elusive.
Ashuai Du, Ashuai Du, Xin Wu, Yunmei Gao, Baili Jiang, Jianlong Wang, Pan Zhang, Qiangqiang Zhao, Qiangqiang Zhao   +8 more
doaj   +1 more source

Pyroptosis‐related gene signatures are associated with prognosis and tumor microenvironment infiltration in head and neck cancer

Health Science Reports, 2023
Background and Aims Recent studies have highlighted the biological significance of pyroptosis in cancer development. Nevertheless, it is still uncertain if pyroptosis also plays a part in immune modulation and the creation of the tumor microenvironment ...
Yan Long, Yadong Wu, Juxiang Peng, Jukun Song, Na Li   +4 more
doaj   +1 more source