Results 21 to 30 of about 199,597 (317)

KRAS mutations and endometriosis burden of disease

The Journal of Pathology: Clinical Research, 2023
AbstractThe clinical phenotype of somatic mutations in endometriosis is unknown. The objective was to determine whether somatic KRAS mutations were associated with greater disease burden in endometriosis (i.e. more severe subtypes and higher stage). This prospective longitudinal cohort study included 122 subjects undergoing endometriosis surgery at a ...
Natasha L Orr, Arianne Albert, Yang Doris Liu, Amy Lum, JooYoon Hong, Catalina L Ionescu, Janine Senz, Tayyebeh M Nazeran, Anna F Lee, Heather Noga, Kate Lawrenson, Catherine Allaire, Christina Williams, Mohamed A Bedaiwy, Michael S Anglesio, Paul J Yong   +15 more
openaire   +3 more sources

Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer

Frontiers in Cell and Developmental Biology, 2022
Increasing evidence indicates that the abnormal expression of N6-methyladenosine (m6A) modification is closely related to the epigenetic regulation of immune response in breast cancer (BC).
Menglu Dong, Wenzhuang Shen, Guang Yang, Zhifang Yang, Xingrui Li   +4 more
doaj   +1 more source

The Clinical Implications of Tumor Mutational Burden in Osteosarcoma [PDF]

Frontiers in Oncology, 2021
BackgroundOsteosarcoma (OTS) is aggressive bone malignancy without well-recognized prognosis biomarker. Tumor mutational burden (TMB) has been proved as effective biomarker in predicting clinical outcomes in several cancer types. However, its prognostic value in OTS remains unknown.
Lu Xie, Yufei Yang, Wei Guo, Dongxue Che, Jie Xu, Xin Sun, Kuisheng Liu, Tingting Ren, Xingyu Liu, Yi Yang, Tao Ji, Xiaodong Tang   +11 more
openaire   +3 more sources

m6A Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Pancreatic Cancer

Frontiers in Immunology, 2021
Recent studies have shown that RNA N6-methyladenosine (m6A) modification plays an important part in tumorigenesis and immune-related biological processes.
Mengyu Sun, Mengyu Sun, Meng Xie, Meng Xie, Tongyue Zhang, Tongyue Zhang, Yijun Wang, Yijun Wang, Wenjie Huang, Wenjie Huang, Limin Xia, Limin Xia   +11 more
doaj   +1 more source

Correlation between LRP1B Mutations and Tumor Mutation Burden in Gastric Cancer [PDF]

Computational and Mathematical Methods in Medicine, 2021
Background. It has been shown that low-density lipoprotein receptor-related protein 1B (LRP1B) mutations correlate with tumor mutation burden (TMB) and prognosis in patients with melanoma and non-small-cell lung cancer, while the relationship between LRP1B mutations and TMB in gastric cancer needs further study.
Sizhe Hu, Xiaokang Zhao, Feng Qian, Cancan Jin, Kaishun Hou   +4 more
openaire   +2 more sources

Cancer immunotherapy: broadening the scope of targetable tumours [PDF]

Open Biology, 2018
Cancer immunotherapy has experienced remarkable advances in recent years. Striking clinical responses have been achieved for several types of solid cancers (e.g.
Jitske van den Bulk, Els ME Verdegaal, Noel FCC de Miranda   +2 more
doaj   +1 more source

Prognostic Value and Therapeutic Perspectives of CXCR Members in the Glioma Microenvironment

Frontiers in Genetics, 2022
Background: CXCR (CXC Chemokine Receptor) is a complex of the immune-associated protein involved in tumor activation, invasion, migration, and angiogenesis through various chemical signals in the tumor microenvironment (TME).
Jiarong He, Zhongzhong Jiang, Jiawei Lei, Wen Zhou, Yan Cui, Biao Luo, Mingming Zhang   +6 more
doaj   +1 more source

DNA Methylation Regulator-Meditated Modification Patterns Define the Distinct Tumor Microenvironment in Lung Adenocarcinoma

Frontiers in Oncology, 2021
BackgroundEpigenetic changes of lung adenocarcinoma (LUAD) have been reported to be a relevant factor in tumorigenesis and cancer progression. However, the molecular mechanisms responsible for DNA methylation patterns in the tumor immune-infiltrating ...
Didi Yuan, Zehong Wei, Yicheng Wang, Fang Cheng, Yujie Zeng, Li Yang, Shangyu Zhang, Jianbo Li, Renkuan Tang   +8 more
doaj   +1 more source

Comprehensive analysis of m7G modification patterns based on potential m7G regulators and tumor microenvironment infiltration characterization in lung adenocarcinoma

Frontiers in Genetics, 2022
Background: The non-negligible role of epigenetic modifications in cancer development and tumor microenvironment (TME) has been demonstrated in recent studies. Nonetheless, the potential regulatory role of N7-methylguanosine (m7G) modification in shaping
Shouzheng Ma, Jun Zhu, Mengmeng Wang, Jianfei Zhu, Wenchen Wang, Yanlu Xiong, Runmin Jiang, Lei Liu, Lei Liu, Tao Jiang   +9 more
doaj   +1 more source

A polygenic burden of rare disruptive mutations in schizophrenia [PDF]

Nature, 2014
By analyzing the exome sequences of 2,536 schizophrenia cases and 2,543 controls, we have demonstrated a polygenic burden primarily arising from rare (
Purcell, S.M., Moran, J.L., Fromer, M., Ruderfer, D., Solovieff, N., Roussos, P., O'Dushlaine, C., Chambert, K., Bergen, S.E., Kähler, A., Duncan, L., Stahl, E., Genovese, G., Fernández, E., Collins, M.O., Komiyama, N.H., Choudhary, J.S., Magnusson, P.K.E., Banks, E., Shakir, K., Garimella, K., Fennell, T., Depristo, M., Grant, S.G., Haggarty, S.J., Gabriel, S., Scolnick, E.M., Lander, E.S., Hultman, C.M., Sullivan, P.F., McCarroll, S.A., Sklar, P.   +31 more
openaire   +6 more sources