Results 31 to 40 of about 199,597 (317)

Mitigating age-related somatic mutation burden

Trends in Molecular Medicine, 2023
Genomes are inherently unstable and require constant DNA repair to maintain their genetic information. However, selective pressure has optimized repair mechanisms in somatic cells only to allow transmitting genetic information to the next generation, not to maximize sequence integrity long beyond the reproductive age. Recent studies have confirmed that
Vijg, Jan, Schumacher, Björn, Abakir, Abdulkadir, Antonov, Michael, Bradley, Chris, Cagan, Alex, Church, George, Gladyshev, Vadim N., Gorbunova, Vera, Maslov, Alexander Y., Reik, Wolf, Sharifi, Samim, Suh, Yousin, Walsh, Kenneth   +13 more
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Identification and Development of Subtypes with Poor Prognosis in Gastric Cancer Based on Both Hypoxia and Immune Cell Infiltration

International Journal of General Medicine, 2021
Yao Wang,1,* Jingjing Sun,1,* Yang Yang,1,* Sonia Zebaze Dongmo,2 Yeben Qian,1 Zhen Wang3 1Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Department of ...
Wang Y, Sun J, Yang Y, Zebaze Dongmo S, Qian Y, Wang Z   +5 more
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Analysis of KRAS Mutation Subtype in Tissue DNA and Cell-Free DNA Using Droplet Digital PCR and the Function of Cell-Free DNA as a Recurrence Predictive Marker in Pancreatic Cancer

Biomedicines, 2021
KRAS mutation is a major regulator in the tumor progression of pancreatic cancer. Here, we compared the frequency and mutation burden of KRAS mutation subtypes with paired tumor tissue and blood in patients and examined their clinical significance.
Eunsung Jun, Bonhan Koo, Eo Jin Kim, Dae Wook Hwang, Jae Hoon Lee, Ki Byung Song, Woohyung Lee, Yejong Park, Sarang Hong, Yong Shin, Song Cheol Kim   +10 more
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Characterization of an Autophagy-Immune Related Genes Score Signature and Prognostic Model and its Correlation with Immune Response for Bladder Cancer

Cancer Management and Research, 2022
JunJie Yu1 *, WeiPu Mao1 *, Si Sun,1 Qiang Hu,1 Can Wang,1 ZhiPeng Xu,1 RuiJi Liu,1 SaiSai Chen,1 Bin Xu,2,3 Ming Chen2,4 1Medical College, Southeast University, Nanjing, 210009, People’s Republic of China; 2Department of Urology, Affiliated ...
Yu J, Mao W, Sun S, Hu Q, Wang C, Xu Z, Liu R, Chen S, Xu B, Chen M   +9 more
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Radiogenomics Map Reveals the Landscape of m6A Methylation Modification Pattern in Bladder Cancer

Frontiers in Immunology, 2021
We aimed to develop a noninvasive radiomics approach to reveal the m6A methylation status and predict survival outcomes and therapeutic responses in patients.
Fangdie Ye, Fangdie Ye, Yun Hu, Yun Hu, Jiahao Gao, Yingchun Liang, Yingchun Liang, Yufei Liu, Yufei Liu, Yuxi Ou, Yuxi Ou, Zhang Cheng, Zhang Cheng, Haowen Jiang, Haowen Jiang, Haowen Jiang   +15 more
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Clinical Impact of Tumor Mutational Burden in Neuroblastoma [PDF]

JNCI: Journal of the National Cancer Institute, 2018
Abstract Background Neuroblastoma is the most common pediatric extracranial solid tumor. Within conventional risk groups, there is considerable heterogeneity in outcomes, indicating the need for improved risk stratification.
William L, Hwang, Rachel L, Wolfson, Andrzej, Niemierko, Karen J, Marcus, Steven G, DuBois, Daphne, Haas-Kogan   +5 more
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Identification of New m6A Methylation Modification Patterns and Tumor Microenvironment Infiltration Landscape that Predict Clinical Outcomes for Papillary Renal Cell Carcinoma Patients

Frontiers in Cell and Developmental Biology, 2022
N6-methyladenosine (m6A) is the product of the most prevalent mRNA modification in eukaryotic cells. Accumulating evidence shows that tumor microenvironment (TME) plays a pivotal role in tumor development. However, the underlying relationship between m6A
Bin Zheng, Bin Zheng, Bin Zheng, Fajuan Cheng, Fajuan Cheng, Zhongshun Yao, Zhongshun Yao, Yiming Zhang, Yiming Zhang, Zixiang Cong, Zixiang Cong, Zixiang Cong, Jianwei Wang, Zhihong Niu, Zhihong Niu, Wei He, Wei He   +16 more
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N6-Methyladenosine Modification Patterns and Tumor Microenvironment Immune Characteristics Associated With Clinical Prognosis Analysis in Stomach Adenocarcinoma

Frontiers in Cell and Developmental Biology, 2022
Background: N6-methyladenosine (m6A) modification is a part of epigenetic research that has gained increasing attention in recent years. m6A modification is widely involved in many biological behaviors of intracellular RNA by regulating mRNA, thus ...
Zhang Meijing, Luo Tianhang, Yang Biao
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A Multi-Omics Study on the Effect of Helicobacter Pylori-Related Genes in the Tumor Immunity on Stomach Adenocarcinoma

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundHelicobacter pylori (HP), a gram-negative spiral-shaped microaerophilic bacterium, colonizes the stomach of approximately 50% of the world’s population, which is considered a risk factor for gastritis, peptic ulcers, gastric cancer, and other ...
Xinrui Wu, Aiwen Jian, Haidan Tang, Wangrui Liu, Wangrui Liu, Fengyuan Liu, Shifan Liu, Huiqun Wu   +7 more
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The mutational burden and oligogenic inheritance in Klippel-Feil syndrome [PDF]

BMC Musculoskeletal Disorders, 2020
Abstract Background Klippel-Feil syndrome (KFS) represents a rare anomaly characterized by congenital fusion of the cervical vertebrae. The underlying molecular etiology remains largely unknown because of the genetic and phenotypic heterogeneity.
Ziquan Li, Sen Zhao, Siyi Cai, Yuanqiang Zhang, Lianlei Wang, Yuchen Niu, Xiaoxin Li, Jianhua Hu, Jingdan Chen, Shengru Wang, Huizi Wang, Gang Liu, Ye Tian, Zhihong Wu, Terry Jianguo Zhang, DISCO (Deciphering Disorders Involving Scoliosis and COmorbidities) study, Yipeng Wang, Nan Wu   +17 more
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