Results 51 to 60 of about 1,875,792 (320)

Current insights into the implications of m6A RNA methylation and autophagy interaction in human diseases

Cell & Bioscience, 2021
Autophagy is a conserved degradation process crucial to maintaining the primary function of cellular and organismal metabolism. Impaired autophagy could develop numerous diseases, including cancer, cardiomyopathy, neurodegenerative disorders, and aging ...
Xuechai Chen, Jianan Wang, Muhammad Tahir, Fangfang Zhang, Yuanyuan Ran, Zongjian Liu, Juan Wang   +6 more
doaj   +1 more source

Identification of New m6A Methylation Modification Patterns and Tumor Microenvironment Infiltration Landscape that Predict Clinical Outcomes for Papillary Renal Cell Carcinoma Patients

Frontiers in Cell and Developmental Biology, 2022
N6-methyladenosine (m6A) is the product of the most prevalent mRNA modification in eukaryotic cells. Accumulating evidence shows that tumor microenvironment (TME) plays a pivotal role in tumor development. However, the underlying relationship between m6A
Bin Zheng, Bin Zheng, Bin Zheng, Fajuan Cheng, Fajuan Cheng, Zhongshun Yao, Zhongshun Yao, Yiming Zhang, Yiming Zhang, Zixiang Cong, Zixiang Cong, Zixiang Cong, Jianwei Wang, Zhihong Niu, Zhihong Niu, Wei He, Wei He   +16 more
doaj   +1 more source

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d [PDF]

, 2018
N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotes, playing crucial roles in multiple biological processes. m6A is catalyzed by the activity of Mettl3, which depends on additional proteins whose precise functions remain poorly ...
Andrade-Navarro, Miguel A., Biggiogera, Marco, Bühler, Marc, Carl, Sarah H., Hares, Tina, Haussmann, Irmgard, Helm, Mark, Hess, Daniel, Jacob, Dominik, Knuckles, Philip, Kreim, Nastasja, Lence, Tina, Masiello, Irene, Roignant, Jean-Yves, Soller, Matthias, Villaseñor, Rodrigo   +15 more
core   +4 more sources

WTAP mediates the anti-inflammatory effect of Astragalus mongholicus polysaccharide on THP-1 macrophages

Frontiers in Pharmacology, 2022
Background:Astragalus mongholicus polysaccharides (APS) have anti-inflammatory, antioxidant and immunomodulatory effects. Recent studies have demonstrated the epigenetic regulation of N6-methyladenosine (m6A) in the development of inflammation.
Haijiao Long, Haijiao Long, Haiyue Lin, Pan Zheng, Lianjie Hou, Ming Zhang, Shuyun Lin, Kai Yin, Guojun Zhao, Guojun Zhao   +9 more
doaj   +1 more source

m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination [PDF]

, 2016
N6-methyladenosine (m6A) is the most common internal modification of eukaryotic messenger RNA (mRNA) and is decoded by YTH domain proteins1, 2, 3, 4, 5, 6, 7.
A Hilfiker, B Moindrot, C Church, C Schütt, C Trapnell, CF Hongay, D Dominissini, D Kim, D Sturgill, D Yan, DP Patil, E Zaharieva, Eugenio Sanchez-Moran, GZ Luo, Helen K. Salz, Irmgard U. Haussmann, IU Haussmann, IU Haussmann, IU Haussmann, J Liu, J Zhou, JA Bokar, JE Harper, JT Robinson, K Horiuchi, KD Meyer, KD Meyer, KJ Livak, LO Penalva, M Niessen, M Soller, M Soller, M Soller, Matthias Soller, Nathan Archer, Nigel P. Mongan, RP Perry, Rupert G. Fray, S Geula, S Ke, S Luo, S Schwartz, S Zhong, SR Starck, W Xiao, X Wang, Z Bodi, Z Bodi, Zsuzsanna Bodi   +48 more
core   +5 more sources

The emerging importance role of m6A modification in liver disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
N6-methyladenosine (m6A) modification, as one of the most common types of inner RNA modification in eukaryotes, plays a multifunctional role in normal and abnormal biological processes.
Sheng Wang, Songsen Gao, Wufei Ye, Yueran Li, Jiajie Luan, Xiong-wen Lv   +5 more
semanticscholar   +1 more source

Structural Insights into N6-methyladenosine (m6A) Modification in the Transcriptome

Genomics, Proteomics & Bioinformatics, 2018
More than 100 types of chemical modifications in RNA have been well documented. Recently, several modifications, such as N6-methyladenosine (m6A), have been detected in mRNA, opening the window into the realm of epitranscriptomics.
Jinbo Huang, Ping Yin
doaj   +1 more source

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis [PDF]

, 2017
Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is fairly well characterized, whereas their role in the modulation of ...
Andronache, Adrian, Bozzoni, Irene, Briganti, Francesca, DI TIMOTEO, Gaia, Fatica, Alessandro, Laneve, Pietro, Legnini, Ivano, Morlando, Mariangela, Rajewsky, Nikolaus, Rossi, Francesca, Santini, Tiziana, Sthandier, Olga Elena, Wade, Mark   +12 more
core   +3 more sources

Crosstalk between N6-methyladenosine (m6A) modification and noncoding RNA in tumor microenvironment

International Journal on Biological Sciences, 2023
N6-methyladenosine (m6A) is the most abundant RNA modification in eukaryotes, and it participates in the regulation of pathophysiological processes in various diseases, including malignant tumors, by regulating the expression and function of both coding ...
Dan Wang, Yingying Han, Lushan Peng, Tao Huang, Xiaoyun He, Junpu Wang, Chunlin Ou   +6 more
semanticscholar   +1 more source

Modulation of translational decoding by m6A modification of mRNA

Nature Communications, 2023
N6-methyladenosine (m6A) is an abundant, dynamic mRNA modification that regulates key steps of cellular mRNA metabolism. m6A in the mRNA coding regions inhibits translation elongation. Here, we show how m6A modulates decoding in the bacterial translation
Sakshi Jain, Lukasz Koziej, Panagiotis Poulis, Igor Kaczmarczyk, Monika Gaik, M. Rawski, Namit Ranjan, S. Glatt, M. Rodnina   +8 more
semanticscholar   +1 more source