Results 51 to 60 of about 836,621 (308)

WTAP mediates the anti-inflammatory effect of Astragalus mongholicus polysaccharide on THP-1 macrophages

Frontiers in Pharmacology, 2022
Background:Astragalus mongholicus polysaccharides (APS) have anti-inflammatory, antioxidant and immunomodulatory effects. Recent studies have demonstrated the epigenetic regulation of N6-methyladenosine (m6A) in the development of inflammation.
Haijiao Long, Haijiao Long, Haiyue Lin, Pan Zheng, Lianjie Hou, Ming Zhang, Shuyun Lin, Kai Yin, Guojun Zhao, Guojun Zhao   +9 more
doaj   +1 more source

FTO Demethylates Cyclin D1 mRNA and Controls Cell-Cycle Progression

Cell Reports, 2020
Summary: N6-Methyladenosine (m6A) modification is the major chemical modification in mRNA that controls fundamental biological processes, including cell proliferation.
Mayumi Hirayama, Fan-Yan Wei, Takeshi Chujo, Shinya Oki, Maya Yakita, Daiki Kobayashi, Norie Araki, Nozomu Takahashi, Ryoji Yoshida, Hideki Nakayama, Kazuhito Tomizawa   +10 more
doaj   +1 more source

Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d [PDF]

, 2018
N6-methyladenosine (m6A) is the most abundant mRNA modification in eukaryotes, playing crucial roles in multiple biological processes. m6A is catalyzed by the activity of Mettl3, which depends on additional proteins whose precise functions remain poorly ...
Andrade-Navarro, MA, Hares, Tina, Hares, T, Helm, M, Haussmann, Irmgard U., Knuckles, P, Biggiogera, M, Hess, Daniel, Hess, D, Buhler, M, Irmgard U. Haussmann, Masiello, Irene, Roignant, JY, Helm, Mark, Roignant, Jean-Yves, Philip Knuckles, Mark Helm, Soller, Matthias, Haussmann, Irmgard, Masiello, I, Tina Lence, Knuckles, Philip, Villaseñor, Rodrigo, Miguel A. Andrade-Navarro, Daniel Hess, Lence, Tina, Irene Masiello, Marc Bühler, Carl, Sarah H., Dominik Jacob, Tina Hares, Kreim, N, Rodrigo Villaseñor, Jean-Yves Roignant, Lence, T, Jacob, Dominik, Biggiogera, Marco, Marco Biggiogera, Sarah H. Carl, Carl, SH, Nastasja Kreim, Jacob, D, Kreim, Nastasja, Andrade-Navarro, Miguel A., Matthias Soller, Villasenior, R, Bühler, Marc, Roignant JY, Carl SH, Hess D, Masiello I, Helm M, Jacob D, Villaseñor R, Kreim N, Biggiogera M, Knuckles P, Bühler M, Soller M, Andrade-Navarro MA, Lence T, Hares T, Haussmann IU   +62 more
core   +1 more source

The crucial roles of m6A RNA modifications in cutaneous cancers: Implications in pathogenesis, metastasis, drug resistance, and targeted therapies

Genes and Diseases, 2023
N6-methyladenosine (m6A) is the most abundant internal modification on RNA. It is a dynamical and reversible process, which is regulated by m6A methyltransferase and m6A demethylase.
Cong Huang, Kaoyuan Zhang, Yang Guo, Changbing Shen, Xiaoming Liu, Haiyan Huang, Xia Dou, Bo Yu   +7 more
doaj   +1 more source

m6aViewer: software for the detection, analysis and visualization of N6-methyl-adenosine peaks from m6A-seq/ME-RIP sequencing data. [PDF]

, 2017
Recent methods for transcriptome-wide N6-methyl-adenosine(m6A) profiling have facilitated investigations into the RNA methylome and established m6A as a dynamic modification that has critical regulatory roles in gene expression and may play a role in ...
David T. Bonthron, Lascelles, C, Crinnion, L, Adrian Whitehouse, Watson, CM, Christopher M. Watson, Belinda Baquero-Perez, Carolina Lascelles, Whitehouse, A, Ian M. Carr, Agne Antanaviciute, Harrison, SM, Antanaviciute, A, Bonthron, DT, Sally M. Harrison, Laura Crinnion, Alexander F. Markham, Markham, AF, Carr, IM, Baquero-Perez, B   +19 more
core   +1 more source

Characterization of m6A methylation modifications in gastric cancer

Aging, 2023
Widely recognized as an essential epitranscriptomic modification, RNA N6-methyladenosine (m6A) is involved in both physiological and pathological processes. Here, we want to investigate m6A modification's potential roles in gastric cancer. Gastric cancer samples were selected from TCGA-STAD and GEO (GSE84426, GSE84433) datasets.
Yin, Wei, Huo, Zhanwei, Zuo, Jiawei, Wang, Haixiao, Chen, Bi, Zhou, Liqing   +5 more
openaire   +2 more sources

Detection, distribution, and functions of RNA N6-methyladenosine (m6A) in plant development and environmental signal responses

Frontiers in Plant Science
The epitranscriptomic mark N6-methyladenosine (m6A) is the most common type of messenger RNA (mRNA) post-transcriptional modification in eukaryotes. With the discovery of the demethylase FTO (FAT MASS AND OBESITY-ASSOCIATED PROTEIN) in Homo Sapiens, this
Yang Xiang, Dian Zhang, Lei Li, Yi-Xuan Xue, Chao-Yang Zhang, Qing-Feng Meng, Jin Wang, Xiao-Li Tan, Yu-Long Li   +8 more
doaj   +1 more source

Identification of genes modified by N6-methyladenosine in patients with colorectal cancer recurrence

Frontiers in Genetics, 2022
Background: Recent studies demonstrate that N6-methyladenosine (m6A) methylation plays a crucial role in colorectal cancer (CRC). Therefore, we conducted a comprehensive analysis to assess the m6A modification patterns and identify m6A-modified genes in ...
Qianru Zhu, Qianru Zhu, Qianru Zhu, Qianru Zhu, Xingxing Huang, Xingxing Huang, Xingxing Huang, Xingxing Huang, Shuxian Yu, Shuxian Yu, Shuxian Yu, Lan Shou, Lan Shou, Lan Shou, Ruonan Zhang, Ruonan Zhang, Ruonan Zhang, Ruonan Zhang, Han Xie, Han Xie, Han Xie, Zimao Liang, Zimao Liang, Zimao Liang, Zimao Liang, Xueni Sun, Xueni Sun, Xueni Sun, Jiao Feng, Jiao Feng, Jiao Feng, Ting Duan, Ting Duan, Ting Duan, Mingming Zhang, Mingming Zhang, Mingming Zhang, Yu Xiang, Yu Xiang, Yu Xiang, Xinbing Sui, Xinbing Sui, Xinbing Sui, Xinbing Sui, Xinbing Sui, Xinbing Sui, Weiwei Jin, Weiwei Jin, Lili Yu, Qibiao Wu, Qibiao Wu, Qibiao Wu, Qibiao Wu   +52 more
doaj   +1 more source

m6A RNA Methylation in marine plants: first insights and relevance for biological rhythms [PDF]

, 2020
Circadian regulations are essential for enabling organisms to synchronize physiology with environmental light-dark cycles. Post-transcriptional RNA modifications still represent an understudied level of gene expression regulation in plants, although they
Silva, João, Miriam Ruocco, Ruocco, Miriam, Isabel Barrote, Chiusano, Maria, Maria Chiusano, Dattolo, Emanuela, Barrote, Isabel, Marlene Jahnke, Gabriele Procaccini, Luca Ambrosino, João Silva, Procaccini, Gabriele, Jahnke, Marlene,, Chiusano, Maria Luisa, Ambrosino, Luca, Emanuela Dattolo, Barote, Isabel, Jahnke, Marlene, Barrote I., Dattolo E., Ambrosino L., Chiusano M. L., Procaccini G., Ruocco M., Jahnke M., Silva J.   +26 more
core   +1 more source

The role of m6A modification in physiology and disease [PDF]

Cell Death & Disease, 2020
AbstractSimilar to DNA epigenetic modifications, multiple reversible chemical modifications on RNAs have been uncovered in a new layer of epigenetic modification. N6-methyladenosine (m6A), a modification that occurs in ~30% transcripts, is dynamically regulated by writer complex (methylase) and eraser (RNA demethylase) proteins, and is recognized by ...
Yang, Chuan, Hu, Yiyang, Zhou, Bo, Bao, Yulu, Li, Zhibin, Gong, Chunli, Yang, Huan, Wang, Sumin, Xiao, Yufeng   +8 more
openaire   +2 more sources