Results 21 to 30 of about 836,621 (308)

Dynamic regulation and functions of mRNA m6A modification [PDF]

Cancer Cell International, 2022
AbstractN6-Methyladenosine (m6A), the most abundant internal modification associated with eukaryotic mRNAs, has emerged as a dynamic regulatory mechanism controlling the expression of genes involved in many physiological activities by affecting various steps of mRNA metabolism, including splicing, export, translation, and stability. Here, we review the
Shanshan Wang, Wei Lv, Tao Li, Shubing Zhang, Huihui Wang, Xuemei Li, Lianzi Wang, Dongyue Ma, Yan Zang, Jilong Shen, Yuanhong Xu, Wei Wei   +11 more
openaire   +3 more sources

N6-Methyladenosine-Sculpted Regulatory Landscape of Noncoding RNA

Frontiers in Oncology, 2021
The exploration of dynamic N6-methyladenosine (m6A) RNA modification in mammalian cells has attracted great interest in recent years. M6A modification plays pivotal roles in multiple biological and pathological processes, including cellular reprogramming,
Zhongyuan Zhang, Wei Wei, Hao Wang, Jiangning Dong   +3 more
doaj   +1 more source

Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification [PDF]

, 2020
Understanding genome organization and gene regulation requires insight into RNA transcription, processing and modification. We adapted nanopore direct RNA sequencing to examine RNA from a wild-type accession of the model plant Arabidopsis thaliana and a ...
Geoffrey J Barton, Mackinnon, Katarzyna, Schurch, Nicholas J., Anna V Sherwood, Sherwood, Anna V., Parker, Matthew T., Barton, Geoffrey J., Simpson, Gordon G., Matthew T Parker, Anthony JW Hall, Gould, Peter D., Gordon G Simpson, Peter D Gould, Hall, Anthony J. W., Knop, Katarzyna, Barton, Geoffrey J.; id_orcid, Nicholas J Schurch, Katarzyna Knop, Katarzyna Mackinnon, Barton, Geoffrey J, Sherwood, Anna V, Gould, Peter D, Schurch, Nicholas J, Hall, Anthony JW, Parker, Matthew T, Simpson, Gordon G   +25 more
core   +1 more source

The role of regulators of RNA m6A methylation in lung cancer

Genes and Diseases, 2023
N6-methyladenosine (m6A) modification is found the most prevalent and abundant post-transcriptional mRNA modification in eukaryotic cells. It regulates almost all stages of RNA life cycle including splicing, translocation, stability, decay and ...
Qicheng Zhang, Ke Xu
doaj   +1 more source

Mixed-weight neural bagging for detecting m6A modifications in SARS-CoV-2 RNA sequencing [PDF]

, 2022
Objective: The m6A modification is the most common ribonucleic acid (RNA) modification, playing a role in prompting the viruss gene mutation and protein structure changes in the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Liu, R., Qi, J., Ou, L., Yang, P., Xue, G., Yang, Po, Yang, X., Yang, Xiaokang, Feng, David Dagan, Sheng, Bin, Liu, Ruhan, Feng, Dagan, Sheng, B., Zhang, Ping, Xue, Guangtao, Zhu, Lei, Li, P., Zhang, P., Li, Ping, Feng, D., Luo, Yuyang, Kim, J., Li, Huating, Ou, Liang, Li, H., Hao, Pei, Hao, P., Xiaokang Yang, Huating Li, Po Yang, Ping Zhang, Bin Sheng, Liang Ou, Pei Hao, Yuyang Luo, Ruhan Liu, Ping Li, David Dagan Feng, Guangtao Xue, Lei Zhu   +39 more
core   +1 more source

The crucial roles of N6-methyladenosine (m6A) modification in the carcinogenesis and progression of colorectal cancer

Cell & Bioscience, 2021
As the predominant modification in RNA, N6-methyladenosine (m6A) has attracted increasing attention in the past few years since it plays vital roles in many biological processes.
Zhihao Fang, Yiqiu Hu, Jinhui Hu, Yanqin Huang, Shu Zheng, Cheng Guo   +5 more
doaj   +1 more source

Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer

Frontiers in Cell and Developmental Biology, 2022
Increasing evidence indicates that the abnormal expression of N6-methyladenosine (m6A) modification is closely related to the epigenetic regulation of immune response in breast cancer (BC).
Menglu Dong, Wenzhuang Shen, Guang Yang, Zhifang Yang, Xingrui Li   +4 more
doaj   +1 more source

WTAP-Mediated m6A Modification of TXNDC5 mRNA Promotes Cervical Carcinogenesis. [PDF]

Kaohsiung J Med Sci
ABSTRACT WT1‐associated protein (WTAP), a core component of the methyltransferase complex, is involved in various tumor pathological processes, but its specific mechanism in cervical cancer (CC) remains unclear. This study, based on single‐cell transcriptomic data (including 3 CC and 2 normal tissues), constructed a CC microenvironment cell atlas ...
Chen L, Hu NX, Chen ZY, Zhu KA, Huang W.
europepmc   +2 more sources

A new perspective on Alzheimer’s disease: m6A modification

Frontiers in Genetics, 2023
As a neurodegenerative disease, Alzheimer’s disease (AD) is characterized by synaptic loss, extracellular plaques of amyloid accumulation, hyperphosphorylation of tau, and neuroinflammation. Various biological processes are affected by epitranscriptomic modifications, which regulate the metabolism of mRNA in cells and regulate the expression of genes ...
Lei Xia, Lei Xia, Lei Xia, Fan Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Yulu Li, Yulu Li, Yulu Li, Yuemi Mo, Yuemi Mo, Yuemi Mo, Lingqiu Zhang, Lingqiu Zhang, Lingqiu Zhang, Qianhua Li, Qianhua Li, Qianhua Li, Minghuang Luo, Minghuang Luo, Minghuang Luo, Xiaotao Hou, Xiaotao Hou, Xiaotao Hou, Xiaotao Hou, Zhengcai Du, Zhengcai Du, Zhengcai Du, Zhengcai Du, Jiagang Deng, Jiagang Deng, Jiagang Deng, Jiagang Deng, Erwei Hao, Erwei Hao, Erwei Hao, Erwei Hao   +38 more
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Ramifications of m6A Modification on ncRNAs in Cancer

Current Genomics, 2023
Abstract:: N6-methyladenosine (m6A) is an RNA modification wherein the N6-position of adenosine is methylated. It is one of the most prevalent internal modifications of RNA and regulates various aspects of RNA metabolism. M6A is deposited by m6A methyltransferases, removed by m6A demethylases, and recognized by reader proteins, which modulate splicing,
openaire   +2 more sources