Results 21 to 30 of about 23,657 (254)
The role of regulators of RNA m6A methylation in lung cancer
Genes and Diseases, 2023 N6-methyladenosine (m6A) modification is found the most prevalent and abundant post-transcriptional mRNA modification in eukaryotic cells. It regulates almost all stages of RNA life cycle including splicing, translocation, stability, decay and ...
Qicheng Zhang, Ke Xu
doaj +1 more source
A new perspective on Alzheimer’s disease: m6A modification
Frontiers in Genetics, 2023 As a neurodegenerative disease, Alzheimer’s disease (AD) is characterized by synaptic loss, extracellular plaques of amyloid accumulation, hyperphosphorylation of tau, and neuroinflammation. Various biological processes are affected by epitranscriptomic modifications, which regulate the metabolism of mRNA in cells and regulate the expression of genes ...
Lei Xia +38 more
openaire +3 more sources
Cell & Bioscience, 2021 As the predominant modification in RNA, N6-methyladenosine (m6A) has attracted increasing attention in the past few years since it plays vital roles in many biological processes.
Zhihao Fang +5 more
doaj +1 more source
Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer
Frontiers in Cell and Developmental Biology, 2022 Increasing evidence indicates that the abnormal expression of N6-methyladenosine (m6A) modification is closely related to the epigenetic regulation of immune response in breast cancer (BC).
Menglu Dong +4 more
doaj +1 more source
N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development
Acta Pharmaceutica Sinica B, 2018 N6-Methyladenosine (m6A) modification is the most pervasive modification of human mRNA molecules. It is reversible via regulation of m6A modification methyltransferase, demethylase and proteins that preferentially recognize m6A modification as “writers”,
Yi Niu +4 more
doaj +1 more source
The functions of N6-methyladenosine modification in lncRNAs
Genes and Diseases, 2020 Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most ...
Rong-Zhang He, Jing Jiang, Di-Xian Luo
doaj +1 more source
m6A Methylation in Cardiovascular Diseases: From Mechanisms to Therapeutic Potential
Frontiers in Genetics, 2022 Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Recent studies have shown that n6-methyladenosine (m6A) plays a major role in cardiovascular homeostasis and pathophysiology.
Longbo Li +5 more
doaj +1 more source
Ramifications of m6A Modification on ncRNAs in Cancer
Current Genomics, 2023 Abstract:: N6-methyladenosine (m6A) is an RNA modification wherein the N6-position of adenosine is methylated. It is one of the most prevalent internal modifications of RNA and regulates various aspects of RNA metabolism. M6A is deposited by m6A methyltransferases, removed by m6A demethylases, and recognized by reader proteins, which modulate splicing,
openaire +2 more sources
The current landscape of m6A modification in urological cancers
PeerJ, 2023 N6-methyladenosine (m6A) methylation is a dynamic and reversible procession of epigenetic modifications. It is increasingly recognized that m6A modification has been involved in the tumorigenesis, development, and progression of urological tumors. Emerging research explored the role of m6A modification in urological cancer.
Zeng, Yaohui +3 more
openaire +3 more sources
Scientific Reports, 2023 N 6-methyladenosine (m6A) is a form of posttranscriptional modification that plays important roles in cancer including oral squamous cell carcinoma (OSCC).
Lu Pan +6 more
doaj +1 more source