Results 21 to 30 of about 1,875,792 (320)
Functional organization of box C/D RNA-guided RNA methyltransferase [PDF]
, 2020 Box C/D RNA protein complexes (RNPs) catalyze site-specific 2'-O-methylation of RNA with specificity determined by guide RNAs. In eukaryotic C/D RNP, the paralogous Nop58 and Nop56 proteins specifically associate with terminal C/D and internal C'/D ...
Huang, Lin +4 more
core +2 more sources
Lactylation of METTL16 promotes cuproptosis via m6A-modification on FDX1 mRNA in gastric cancer
Nature Communications, 2023 Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a potential cancer therapeutic. However, the mechanisms underlying the initiation, propagation, and ultimate execution of cuproptosis in tumors remain unknown.
Lianhui Sun +12 more
semanticscholar +1 more source
Functional Dissection of the m6A RNA Modification [PDF]
Trends in Biochemical Sciences, 2017 Much work over the past three decades has established that chemical modifications of DNA and histones are intimately linked with various facets of DNA metabolism, most notably transcription. In addition to chromatin components, RNA has long been known to be chemically modified [1]. The N6-methyladenosine (m6A) RNA modification has recently emerged as a
Brooke, Huisman +3 more
openaire +2 more sources
The Role of m6A Modification and m6A Regulators in Esophageal Cancer
Cancers, 2022 N6-methyladenosine (m6A) modification, the most prevalent RNA modification, is involved in all aspects of RNA metabolism, including RNA processing, nuclear export, stability, translation and degradation. Therefore, m6A modification can participate in various physiological functions, such as tissue development, heat shock response, DNA damage response ...
Li, Yuekao +8 more
openaire +2 more sources
Arthritis Research & Therapy, 2023 Background N6-methyladenosine (m6A) methylation modification is involved in the regulation of various biological processes, including inflammation, antitumor, and antiviral immunity. However, the role of m6A modification in the pathogenesis of autoimmune
Yurong Huang +7 more
doaj +1 more source
The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases
Frontiers in Genetics, 2022 N6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA modification. m6A modification is a dynamic and reversible post-transcriptional regulatory modification, initiated by methylase and removed by RNA demethylase. m6A-binding
Jin Sun +19 more
doaj +1 more source
N6-Methyladenosine-Sculpted Regulatory Landscape of Noncoding RNA
Frontiers in Oncology, 2021 The exploration of dynamic N6-methyladenosine (m6A) RNA modification in mammalian cells has attracted great interest in recent years. M6A modification plays pivotal roles in multiple biological and pathological processes, including cellular reprogramming,
Zhongyuan Zhang +3 more
doaj +1 more source
The role of regulators of RNA m6A methylation in lung cancer
Genes and Diseases, 2023 N6-methyladenosine (m6A) modification is found the most prevalent and abundant post-transcriptional mRNA modification in eukaryotic cells. It regulates almost all stages of RNA life cycle including splicing, translocation, stability, decay and ...
Qicheng Zhang, Ke Xu
doaj +1 more source
Cell & Bioscience, 2021 As the predominant modification in RNA, N6-methyladenosine (m6A) has attracted increasing attention in the past few years since it plays vital roles in many biological processes.
Zhihao Fang +5 more
doaj +1 more source
International Journal on Biological Sciences, 2022 Neutrophil extracellular traps (NETs) production is a major strategy employed by polymorphonuclear neutrophils (PMNs) to fight against microbes. NETs have been implicated in the pathogenesis of various lung injuries, although few studies have explored ...
Hao Zhang +11 more
semanticscholar +1 more source