Results 141 to 150 of about 15,062 (245)
METTL3 has no effects on CSFV replication. [PDF]
(A and C) PK-15, IPEC-J2, and ST cells transfected with siMETTL3 and siCtrl (A) or pEGFP-METTL3 (0.2, 0.5 and 1 μg) (C) were infected with CSFV (MOI = 1). At 24 hpi, the total RNA were extracted or lysated and subjected to RT-qPCR or virus titration.
Bing-qian Zhao (18275791) +8 more
core +1 more source
Roles of METTL3 and NLRP3 in pyroptosis and prospects in SCIRI
Frontiers in ImmunologySpinal cord ischemia-reperfusion injury (SCIRI) leads to severe neurological deficits, with pyroptosis emerging as a key driver of inflammation and neuronal death. Recent studies suggest that methyltransferase-like 3 (METTL3), a critical RNA methyltransferase, may regulate the nucleotide-binding oligomerized structural domain-like receptor protein 3 ...
Xiaoqing Guan +4 more
openaire +3 more sources
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao +4 more
wiley +1 more source
RNA Binding by the m6A Methyltransferases METTL16 and METTL3
BiologyMethyltransferases are a wide-ranging, yet well-conserved, class of molecules that have been found to modify a wide variety of substrates. Interest in RNA methylation has surged in recent years with the identification of the major eukaryotic mRNA m6A methyltransferase METTL3.
openaire +3 more sources
Glucose Transporter 1 in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.As the quintessential facilitator of basal glucose uptake, glucose transporter 1 (GLUT1) is indispensable for maintaining systemic energy homeostasis. This graphical abstract delineates the multidimensional landscape of GLUT1 in normal physiology. It highlights its tissue‐specific metabolic roles—from fueling erythrocytes and fetal development to ...
Yi Tai +3 more
wiley +1 more source
International Dental JournalBackground: Waterpipe smoking (WPS) is increasingly recognized as a risk factor for oral squamous cell carcinoma (OSCC), but the molecular mechanisms are still not well understood.
Prathibha Prasad +5 more
doaj +1 more source
MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities
Cancer Science, Volume 117, Issue 8, Page 2050-2063, August 2026.Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah +3 more
wiley +1 more source
Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease
Cell Proliferation, Volume 59, Issue 8, August 2026.Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik +10 more
wiley +1 more source
Correlation between METTL3 overexpression and 18F-FDG uptake in patients with soft tissue sarcoma [PDF]
Background N6-methyladenosine (m6A) methylation plays a key role in tumor progression. However, the significance of methyltransferase-like 3 (METTL3) in biological processes of soft tissue sarcoma (STS) patients, and the relationship between METTL3 and ...
Hongbo Feng +5 more
core +1 more source
Coilin mediates m6A RNA methylation through phosphorylation of METTL3
Biology Open, 2023 Douglas M. McLaurin +2 more
doaj +1 more source