Results 151 to 160 of about 13,391 (192)

Correction: METTL3 accelerates staphylococcal protein A (SpA)-induced osteomyelitis progression by regulating m6A methylation-modified miR-320a. [PDF]

J Orthop Surg Res
Gao D, Shi J, Lu S, Li J, Lv K, Xu Y, Song M.   +6 more
europepmc   +1 more source

Targeting m⁶A RNA methylation to sensitize cancer cells to DNA-damaging therapies. [PDF]

Discov Oncol
Cesaro B, Venezia S, Tarullo M, Piscopo F, Fatica A.   +4 more
europepmc   +1 more source

Methyltransferase complex subunit METTL3 maintains genome stability of erythroid cells via MTHFD1-mediated nucleotide biosynthesis. [PDF]

J Clin Invest
Zhang L, Zhao H, Wang S, Wu X, Liu D, Zhang H, Yang Q, Cheng Y, Wu X, Zhao J, Zhang S, Zhang H, Zhang H, Kang Q, Chen L, An X, Qu X.   +16 more
europepmc   +1 more source

METTL3 Inhibitors for Epitranscriptomic Modulation of Cellular Processes

ChemMedChem, 2021
Abstract The methylase METTL3 is the writer enzyme of the N 6 ‐methyladenosine (m 6 A) modification of RNA. Using a structure‐based drug discovery approach, we identified a METTL3 inhibitor with potency in a biochemical assay of 280 nM,
Elena V Moroz-Omori, Danzhi Huang, Rajiv Kumar Bedi   +2 more
exaly   +3 more sources

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UVB promotes melanogenesis by regulating METTL3

Journal of Cellular Physiology, 2023
AbstractUltraviolet (UV) radiation is the primary exogenous inducer of skin pigmentation, although the mechanism has not been fully elucidated. N6‐methyladenosine (m6A) modification is one of the key epigenetic form of gene regulation that affects multiple biological processes.
Haoran Guo, Hongliang Zeng, Yibo Hu, Ling Jiang, Li Lei, Jinhua Hung, Chuhan Fu, Hui Li, Yan Long, Jing Chen, Qinghai Zeng   +10 more
openaire   +2 more sources

The Role of METTL3 in the Progression of Cardiac Fibrosis

Current Topics in Medicinal Chemistry, 2023
Abstract: Cardiac fibrosis is known as the expansion of the cardiac interstitium through excessive deposition of extracellular matrix proteins; this process is performed by a multifunctional cell known as the cardiac fibroblast. After the myocardial injury, these cells are activated as a repair program, increase, and switch to a contractile phenotype,
Samir Bolívar, Marian Pérez-Cantillo, Jassiris Monterroza-Torres, César Vásquez-Trincado, Jairo Castellar-Lopez, Evelyn Mendoza-Torres   +5 more
openaire   +2 more sources

RNA secondary structure dependence in METTL3–METTL14 mRNA methylation is modulated by the N-terminal domain of METTL3

Biological Chemistry, 2020
Abstract N 6-methyladenosine (m6A) is the most abundant modification in mRNA. The core of the human N 6-methyltransferase complex (MTC) is formed by a heterodimer consisting of METTL3 and METTL14, which specifically catalyzes m6A formation within an RRACH sequence context.
Nathalie Meiser, Nicole Mench, Martin Hengesbach   +2 more
openaire   +2 more sources

METTL3 is required for maintaining β-cell function

Metabolism, 2021
N6-methyladenosine (m6A) mRNA methylation has been shown to regulate obesity and type 2 diabetes. However, whether METTL3, the key methyltransferase for m6A mRNA methylation, regulates β-cell failure in diabetes has not been fully explored. Here, we show that METTL3 is downregulated under the inflammatory and oxidative stress conditions, and islet β ...
Xinzhi, Li, Yuze, Jiang, Xu, Sun, Yongsen, Wu, Zheng, Chen   +4 more
openaire   +2 more sources