Results 161 to 170 of about 13,391 (192)

METTL3: a multifunctional regulator in diseases

Molecular and Cellular Biochemistry
N6-methyladenosine (m6A) methylation is the most prevalent and abundant internal modification of mRNAs and is catalyzed by the methyltransferase complex. Methyltransferase-like 3 (METTL3), the best-known m6A methyltransferase, has been confirmed to function as a multifunctional regulator in the reversible epitranscriptome modulation of m6A modification
Na, Li, Xiang, Wei, Jian, Dai, Jinfeng, Yang, Sizheng, Xiong   +4 more
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Inhibition of Mettl3 by STM2457 and Loss of Macrophage Mettl3 Alleviate Pulmonary Hypertension and Right Heart Remodeling

Lung
m6A RNA methylation is a critical epigenetic modification involved in the pathogenesis of pulmonary arterial hypertension (PAH). While macrophage-mediated inflammation plays a central role in PAH, the specific contributions of m6A regulators within macrophages are not yet fully understood.
Chunfeng, He, Yingqun, Ji, Yan, Zhang, Jinbo, Ou, Di, Wu, Huan, Qin, Jing, Hua, Qiang, Li, Hao, Zheng   +8 more
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Discovery of a PROTAC degrader for METTL3-METTL14 complex

Cell Chemical Biology
N6-methyladenosine (m6A) methylation is the most abundant type of RNA modification that is mainly catalyzed by the METTL3-METTL14 methyltransferase complex. This complex has been linked to multiple cancers and is considered a promising therapeutic target for acute myeloid leukemia (AML).
Yaoliang Sun, Qiongyu Shi
exaly   +3 more sources

Prognostic roles of dysregulated METTL3 protein expression in cancers and potential anticancer value by inhibiting METTL3 function

Fundamental & Clinical Pharmacology
AbstractBackgroundMany studies have demonstrated the relationship between METTL3 protein expression and clinical outcomes in various cancers and elucidated the mechanism by which METTL3 disrupts the behavior of cancer cells. Here, we attempted to define the prognostic value of METTL3 protein in patients with cancer via systematic analysis and explored ...
Rong Zhao, Jiaping Chen, Yangwei Wang, Han Xiao, Peiyuan Mei, Wei Lin, Mingxin Diao, Shiwen He, Yongde Liao, Wangyang Meng   +9 more
openaire   +2 more sources

Localization-dictated function for METTL3

Nature Cell Biology, 2022
Sylvain Delaunay, Michaela Frye
openaire   +2 more sources

METTL3: Melting the tumor microenvironment for improved immunotherapy

Cell Chemical Biology
The tumor microenvironment (TME) dictates the outcome of cancer immunotherapy. In this issue of Cell Chemical Biology, Yu et al.1 report that targeting Mettl3 leads to a more inflamed, "hot" TME and effective anti-PD-1 therapy. This study points to a new target in remodeling the TME for improved immunotherapy.
Longfei, Gao, Lei, Ding
openaire   +2 more sources

A Cleaved METTL3 Potentiates the METTL3-WTAP Interaction and Cancer Progression

SSRN Electronic Journal, 2022
Chaojun Yan, Jingjing Xiong, Zirui Zhou, Qifang Li, Chuan Gao, Mengyao Zhang, Liya Yu, Jinpeng Li, Ming-Ming Hu, Chen-Song Zhang, Cheguo Cai, Haojian Zhang, Jing Zhang   +12 more
openaire   +1 more source

METTL3 contributes to the pathogenesis of AKI

Nature Reviews Nephrology, 2022
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METTL3 Is Essential for Exercise Benefits in Diabetic Cardiomyopathy

Circulation
BACKGROUND: Exercise improves functional outcomes in patients with diabetic cardiomyopathy (DiaCM). The molecular mechanism underlying cardiac benefits of exercise in DiaCM remains incompletely understood. N6-methyladenosine (m6A) is the most common form of messenger RNA modification in eukaryotes and has been implicated in ...
Chunyan Wang, Siman Shen, Jiayi Kang, Aya Sugai-Munson, Xiao Xiao, Yajing Zhang, Junyuan Zhu, Zipeng Liu, Tina B. McKay, Oluwaseun Akeju, Eric R. Jonas, Amrut V. Ambardekar, Michael R. Bristow, Weifeng Yao, Haobo Li   +14 more
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Role of m6A methyltransferase METTL3 in keratoconus pathogenesis

Experimental Eye Research
Keratoconus (KC) is the most common ectatic corneal disease with unknown pathogenesis. This study aimed to investigate the role of methyltransferase-like enzyme 3 (METTL3) in KC pathogenesis. In the present study, we examined the levels of METTL3 and other N6-methyladenosine (m6A) modification-related proteins in KC samples and human stromal keratocyte
Huimin Yu, Shengqian Dou, Huijin Wang, Yaru Sun, Junpeng Qu, Ting Liu, Xiaoxue Liu, Chao Wei, Hua Gao   +8 more
openaire   +2 more sources