Results 31 to 40 of about 30,822 (300)
Frontiers in Medicine, 2021 Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Jingchao Liu +17 more
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Deciphering the epitranscriptome: a green perspective [PDF]
, 2016 The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation - the epitranscriptome.
Burgess, A., David, R., Searle, I.
core +1 more source
N6-methyladenosine methyltransferases: functions, regulation, and clinical potential [PDF]
Journal of Hematology & Oncology, 2021 AbstractN6-methyladenosine (m6A) has emerged as an abundant modification throughout the transcriptome with widespread functions in protein-coding and noncoding RNAs. It affects the fates of modified RNAs, including their stability, splicing, and/or translation, and thus plays important roles in posttranscriptional regulation.
Wei Huang +5 more
openaire +3 more sources
Yeast m6 A methylated mRNAs are enriched on translating ribosomes during meiosis, and under rapamycin treatment [PDF]
, 2015 Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of FTO’s (Fat Mass Obesity) N6-methyladenosine (m6 A) deaminase activity, thus suggesting a link between obesity ...
Archer, Nathan +5 more
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Benchmark data for identifying N6-methyladenosine sites in the Saccharomyces cerevisiae genome
Data in Brief, 2015 This data article contains the benchmark dataset for training and testing iRNA-Methyl, a web-server predictor for identifying N6-methyladenosine sites in RNA (Chen et al., 2015 [15]).
Wei Chen +4 more
doaj +1 more source
Liver-specific Mettl3 ablation delays liver regeneration in mice
Genes and Diseases, 2022 This study investigated the role of N6-methyladenosine RNA methylation in liver regeneration following partial hepatectomy in mice. We created a liver-specific knockout mouse model by the deletion of Mettl3, a key component of the N6-methyladenosine ...
Jiaxiang Meng +3 more
doaj +1 more source
Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA [PDF]
, 2018 The AlkB protein is a repair enzyme that uses an α-ketoglutarate/Fe(II)-dependent mechanism to repair alkyl DNA adducts. AlkB has been reported to repair highly susceptible substrates, such as 1-methyladenine and 3-methylcytosine, more efficiently in ss ...
Bian, Ke +8 more
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Transcriptome-wide N6-methyladenosine analysis [PDF]
Nature Reviews Genetics, 2012 Two groups have developed a technique for analysing the transcriptome-wide distribution of the RNA modification N6-methyladenosine (m6A) that incorporates antibody-mediated enrichment of the modification coupled with sequencing. Notably, in humans and mice, there was an enrichment for the mark around stop codons.
openaire +1 more source
Chinese Medicine, 2021 Background Epimedin C, one of the main active ingredients of Epimedium, has been reported to have potential hepatotoxicity. However, the mechanism of Epimedin C-induced liver injury has not been studied.
Zhizhen Song +4 more
doaj +1 more source
Effect of methylation of adenine N6 on kink turn structure depends on location [PDF]
, 2019 N6-methyladenine is the most common covalent modification in cellular RNA species, with demonstrated functional consequences. At the molecular level this methylation could alter local RNA structure, and/or modulate the binding of specific proteins.
Bokar JA +3 more
core +2 more sources