Results 31 to 40 of about 53,902 (279)

sj-doc-1-jbm-10.1177_03936155231184908 - Supplemental material for Prognostic significance of N6-methyladenosine-modified related chemotransferase METTL3 in gastric carcinoma: Evidence from meta-analysis

, 2023
Supplemental material, sj-doc-1-jbm-10.1177_03936155231184908 for Prognostic significance of N6-methyladenosine-modified related chemotransferase METTL3 in gastric carcinoma: Evidence from meta-analysis by Chenglou Zhu, Qiong Wu, Yan Xu, Jichun Ma ...
Junhong Wang (2460004), Yongli Hu (255161), Yan Xu (14594), Mingxu Da (11415866), Chenglou Zhu (16483694), Jichun Ma (15157054), Zhenhua Gao (501522), Qiong Wu (84327)   +7 more
core   +1 more source

Functions of N6-methyladenosine and its role in cancer [PDF]

Molecular Cancer, 2019
AbstractN6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which is the most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests that m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis.
Liuer He, Huiyu Li, Anqi Wu, Yulong Peng, Guang Shu, Gang Yin   +5 more
openaire   +3 more sources

Table_3_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.XLSX

, 2021
The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439), Yue Shi (128342), Weimin Ci (4459504), Yanliang Dou (11472436), Yu Xiao (150812), Mingxin Zhang (4898947), Jie Qi (53195), Jianye Zhang (430972)   +7 more
core   +1 more source

N6-methyladenosine marks primary microRNAs for processing [PDF]

Nature, 2015
The first step in the biogenesis of microRNAs is the processing of primary microRNAs (pri-miRNAs) by the microprocessor complex, composed of the RNA-binding protein DGCR8 and the type III RNase DROSHA. This initial event requires recognition of the junction between the stem and the flanking single-stranded RNA of the pri-miRNA hairpin by DGCR8 followed
Alarcón, Claudio R, Lee, Hyeseung, Goodarzi, Hani, Halberg, Nils, Tavazoie, Sohail F   +4 more
openaire   +6 more sources

ALKBH5 prevents hepatocellular carcinoma progression by post-transcriptional inhibition of PAQR4 in an m6A dependent manner

Experimental Hematology & Oncology, 2023
Background N6-methyladenosine (m6A) is a prevalent modification of mRNA and is known to play important roles in tumorigenesis in many types of cancer. The function of N6-methyladenosine (m6A) RNA methylation depends on a variety of methyltransferases and
Weijian Wang, Qibo Huang, Zhibin Liao, Hongwei Zhang, Yachong Liu, Furong Liu, Xiaoping Chen, Bixiang Zhang, Yan Chen, Peng Zhu   +9 more
doaj   +1 more source

Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer

Frontiers in Medicine, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Jingchao Liu, Jingchao Liu, Jianlong Wang, Meng Wu, Wei Zhang, Wei Zhang, Lingfeng Meng, Lingfeng Meng, Jiawen Wang, Jiawen Wang, Zhengtong Lv, Zhengtong Lv, Haoran Xia, Haoran Xia, Yaoguang Zhang, Yaoguang Zhang, Jianye Wang, Jianye Wang   +17 more
doaj   +1 more source

Table_6_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.XLSX

, 2021
The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439), Yue Shi (128342), Weimin Ci (4459504), Yanliang Dou (11472436), Yu Xiao (150812), Mingxin Zhang (4898947), Jie Qi (53195), Jianye Zhang (430972)   +7 more
core   +1 more source

Table_1_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.XLSX

, 2021
The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439), Yue Shi (128342), Weimin Ci (4459504), Yanliang Dou (11472436), Yu Xiao (150812), Mingxin Zhang (4898947), Jie Qi (53195), Jianye Zhang (430972)   +7 more
core   +1 more source

Liver-specific Mettl3 ablation delays liver regeneration in mice

Genes and Diseases, 2022
This study investigated the role of N6-methyladenosine RNA methylation in liver regeneration following partial hepatectomy in mice. We created a liver-specific knockout mouse model by the deletion of Mettl3, a key component of the N6-methyladenosine ...
Jiaxiang Meng, Zhicong Zhao, Zhifeng Xi, Qiang Xia   +3 more
doaj   +1 more source

Table_2_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.XLSX

, 2021
The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439), Yue Shi (128342), Weimin Ci (4459504), Yanliang Dou (11472436), Yu Xiao (150812), Mingxin Zhang (4898947), Jie Qi (53195), Jianye Zhang (430972)   +7 more
core   +1 more source