Results 11 to 20 of about 30,822 (300)
N6-methyladenosine methylation in kidney injury
Clinical Epigenetics, 2023 Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed.
Qimeng Wang +10 more
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Epigenetic regulation of N6‐methyladenosine modifications in obesity [PDF]
Journal of Diabetes Investigation, 2021 Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity‐associated metabolic diseases ...
Mingli Sun, Xinan Zhang
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N6-Methyladenosine and Viral Infection [PDF]
Frontiers in Microbiology, 2019 N6-methyladenosine (m6A), as a dynamic posttranscriptional RNA modification, recently gave rise to the field of viral epitranscriptomics. The interaction between virus and host is affected by m6A. Multiple m6A-modified viral RNAs have been observed.
Wei Dang +11 more
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Function of N6-Methyladenosine Modification in Tumors [PDF]
Journal of Oncology, 2021 N6-Methyladenosine (m6A) modification is a dynamic and reversible methylation modification at the N6-position of adenosine. As one of the most prevalent posttranscriptional methylation modifications of RNA, m6A modification participates in several mRNA processes, including nuclear export, splicing, translation, and degradation.
Nan Zhang +3 more
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N6-Methyladenosine Methylation of mRNA in Cell Senescence
Cellular and Molecular Neurobiology, 2021 Cell senescence is the growth arrest caused by the accumulation of irreparable cell damage, which is involved in physiological and pathological processes and regulated by the post-transcriptional level. This regulation is performed by transcriptional regulators and driven by aging-related small RNAs, long non-coding RNAs, and RNA-binding proteins.
Lin Zhang, Jian Xia
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N6-Methyladenosine RNA Methylation in Cardiovascular Diseases
Frontiers in Cardiovascular Medicine, 2022 N6-methyladenosine (m6A) modification is the most universal and abundant post-transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR (m6A) CH (R = A or G, H = A, C, or U) in long internal exons, near stop codons, or in the 3′ untranslated region (UTR).
Chi Liu +8 more
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RNA N6-methyladenosine methylation and skin diseases
Autoimmunity, 2023 Skin diseases are global health issues caused by multiple pathogenic factors, in which epigenetics plays an invaluable role. Post-transcriptional RNA modifications are important epigenetic mechanism that regulate gene expression at the genome-wide level. N6-methyladenosine (m6A) is the most prevalent modification that occurs in the messenger RNAs (mRNA)
Yaqin Yu +6 more
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Regulation of N6-Methyladenosine after Myocardial Infarction
Cells, 2022 Development of heart failure (HF) after myocardial infarction (MI) is responsible for premature death. Complex cellular and molecular mechanisms are involved in this process. A number of studies have linked the epitranscriptomic RNA modification N6-methyladenosine (m6A) with HF, but it remains unknown how m6A affects the risk of developing HF after MI.
Mélanie Vausort +10 more
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N6-Methyladenosine-Sculpted Regulatory Landscape of Noncoding RNA [PDF]
Frontiers in Oncology, 2021 The exploration of dynamic N6-methyladenosine (m6A) RNA modification in mammalian cells has attracted great interest in recent years. M6A modification plays pivotal roles in multiple biological and pathological processes, including cellular reprogramming, fertility, senescence, and tumorigenesis.
Zhongyuan Zhang +3 more
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N6-Methyladenosine Role in Acute Myeloid Leukaemia [PDF]
International Journal of Molecular Sciences, 2018 We are currently assisting in the explosion of epitranscriptomics, which studies the functional role of chemical modifications into RNA molecules. Among more than 100 RNA modifications, the N6-methyladenosine (m6A), in particular, has attracted the interest of researchers all around the world.
Ianniello, Zaira, Fatica, Alessandro
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