Results 11 to 20 of about 53,902 (279)

Epigenetic regulation of N6‐methyladenosine modifications in obesity [PDF]

Journal of Diabetes Investigation, 2021
Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity‐associated metabolic diseases ...
Mingli Sun, Xinan Zhang
doaj   +3 more sources

Function of N6-Methyladenosine Modification in Tumors [PDF]

Journal of Oncology, 2021
N6-Methyladenosine (m6A) modification is a dynamic and reversible methylation modification at the N6-position of adenosine. As one of the most prevalent posttranscriptional methylation modifications of RNA, m6A modification participates in several mRNA processes, including nuclear export, splicing, translation, and degradation.
Nan Zhang, Yuxin Zuo, Yu Peng, Lielian Zuo   +3 more
openaire   +2 more sources

N6-methyladenosine in DNA promotes genome stability

eLife
DNA base lesions, such as incorporation of uracil into DNA or base mismatches, can be mutagenic and toxic to replicating cells. To discover factors in repair of genomic uracil, we performed a CRISPR knockout screen in the presence of floxuridine, a ...
Brooke A Conti, Leo Novikov, Deyan Tong, Qing Xiang, Savon Vigil, Thomas J McLellan, Chuong Nguyen, Nancy De La Cruz, Reshma T Veettil, Prashant Pradhan, Parag Sahasrabudhe, Jason D Arroyo, Lei Shang, Benjamin R Sabari, David J Shields, Mariano Oppikofer   +15 more
doaj   +3 more sources

Insights into the role of N6-methyladenosine in ferroptosis

Biomedicine & Pharmacotherapy, 2023
N6-methyladenosine (m6A) methylation modification is one of the most prevalent epigenetic modifications of eukaryotic RNA. m6A methylation is widely associated with many biological processes through the modification of RNA metabolism and is associated with multiple disease states. As a newly discovered regulatory cell death in recent years, ferroptosis
Jingyuan, Zhang, Tianming, Qiu, Xiaofeng, Yao, Xiance, Sun   +3 more
openaire   +2 more sources

SERPINE1 Alternative Polyadenylation Influences Gastric Cancer Prognosis via N6-Methyladenosine Modification. [PDF]

Cancer Sci
Multi‐omics integration of the transcriptomic APA landscape and m6A modifications identifies key prognostic genes. Their biological functions and molecular mechanisms in promoting tumor progression are comprehensively validated through in vitro assays. ABSTRACT Alternative polyadenylation (APA) and N6‐methyladenosine (m6A) methylation are critical post‐
Wu Z, Xu R, Fang J, Liu B, Zhang C, Zhang S, Ni J.   +6 more
europepmc   +2 more sources

Function and evolution of RNA N6-methyladenosine modification [PDF]

International Journal of Biological Sciences, 2020
N6-methyladenosine (m6A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases METTL3, METTL14 and WTAP (Writers),
Zhu, Zhi-Man, Huo, Fu-Chun, Pei, Dong-Sheng   +2 more
openaire   +2 more sources

circRNA N6-methyladenosine methylation in preeclampsia and the potential role of N6-methyladenosine-modified circPAPPA2 in trophoblast invasion

Scientific Reports, 2021
AbstractHere, we performed N6-methyladenosine (m6A) RNA sequencing to determine the circRNA m6A methylation changes in the placentas during the pathogenesis of preeclampsia (PE). We verified the expression of the circRNA circPAPPA2 using quantitative reverse transcription-PCR.
Yonggang Zhang, Hongling Yang, Yan Long, Yipeng Zhang, Ronggui Chen, Junzhu Shi, Jiying Chen   +6 more
openaire   +3 more sources

Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer

Cancer Biology & Medicine, 2020
The biological roles of N6 methylation of nucleic acids have been extensively studied. Adenine methylation of RNA is the most prevalent RNA modification and has widespread effects on RNA splicing, translation, localization, and stability.
Zhixian Liang, Reilly L. Kidwell, Haijing Deng, Qi Xie   +3 more
doaj   +1 more source

Impact of N6-methyladenosine (m6A) modification on immunity

Cell Communication and Signaling, 2022
AbstractN6-methyl-adenosine (m6A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m6A relies on m6A writers, erasers and readers. m6A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels.
Raghda A. Elsabbagh, Mona Rady, Carsten Watzl, Khaled Abou-Aisha, Mohamed Z. Gad   +4 more
openaire   +3 more sources

N6-Methyladenosine RNA Methylation in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2022
N6-methyladenosine (m6A) modification is the most universal and abundant post-transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR (m6A) CH (R = A or G, H = A, C, or U) in long internal exons, near stop codons, or in the 3′ untranslated region (UTR).
Chi Liu, Chi Liu, Lei Gu, Wenjuan Deng, Qianchao Meng, Nan Li, Guifeng Dai, Suli Yu, Hong Fang   +8 more
openaire   +3 more sources