Results 11 to 20 of about 20,108 (223)
N6-methyladenosine methylation in kidney injury
Clinical Epigenetics, 2023 Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed.
Qimeng Wang +10 more
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Epigenetic regulation of N6‐methyladenosine modifications in obesity [PDF]
Journal of Diabetes Investigation, 2021 Obesity is a serious health issue in the world and is related to a higher risk of suffering metabolic diseases. Understanding the molecular basis of obesity is critical to identify new targets to treat obesity and obesity‐associated metabolic diseases ...
Mingli Sun, Xinan Zhang
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Function of N6-Methyladenosine Modification in Tumors [PDF]
Journal of Oncology, 2021 N6-Methyladenosine (m6A) modification is a dynamic and reversible methylation modification at the N6-position of adenosine. As one of the most prevalent posttranscriptional methylation modifications of RNA, m6A modification participates in several mRNA processes, including nuclear export, splicing, translation, and degradation.
Nan Zhang +3 more
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Insights into the role of N6-methyladenosine in ferroptosis
Biomedicine & Pharmacotherapy, 2023 N6-methyladenosine (m6A) methylation modification is one of the most prevalent epigenetic modifications of eukaryotic RNA. m6A methylation is widely associated with many biological processes through the modification of RNA metabolism and is associated with multiple disease states. As a newly discovered regulatory cell death in recent years, ferroptosis
Jingyuan, Zhang +3 more
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Function and evolution of RNA N6-methyladenosine modification [PDF]
International Journal of Biological Sciences, 2020 N6-methyladenosine (m6A) is identified as the most prevalent and abundant internal RNA modification, especially within eukaryotic mRNAs, which has attracted much attention in recent years since its importance for regulating gene expression and deciding cell fate. m6A modification is installed by RNA methyltransferases METTL3, METTL14 and WTAP (Writers),
Zhu, Zhi-Man +2 more
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Scientific Reports, 2021 AbstractHere, we performed N6-methyladenosine (m6A) RNA sequencing to determine the circRNA m6A methylation changes in the placentas during the pathogenesis of preeclampsia (PE). We verified the expression of the circRNA circPAPPA2 using quantitative reverse transcription-PCR.
Yonggang Zhang +6 more
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Impact of N6-methyladenosine (m6A) modification on immunity
Cell Communication and Signaling, 2022 AbstractN6-methyl-adenosine (m6A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m6A relies on m6A writers, erasers and readers. m6A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels.
Raghda A. Elsabbagh +4 more
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N6-Methyladenosine RNA Methylation in Cardiovascular Diseases
Frontiers in Cardiovascular Medicine, 2022 N6-methyladenosine (m6A) modification is the most universal and abundant post-transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR (m6A) CH (R = A or G, H = A, C, or U) in long internal exons, near stop codons, or in the 3′ untranslated region (UTR).
Chi Liu +8 more
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The functions of N6-methyladenosine modification in lncRNAs
Genes & Diseases, 2020 Increasing evidence indicates that mRNAs are often subject to posttranscriptional modifications. Among them, N6-methyladenosine (m6A), which has been shown to play key roles in RNA splicing, stability, nuclear export, and translation, is the most abundant modification of RNA.
Rong-Zhang He, Jing Jiang, Di-Xian Luo
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N6 -Methyladenosine Negatively Regulates Human Respiratory Syncytial Virus Replication
Frontiers in Cell and Developmental Biology, 2021 N6-methyladenosine (m6A) is the most abundant internal modification described in eukaryotic mRNA and several viral RNA including human respiratory syncytial virus (HRSV).
Fabian Figueroa +15 more
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