Results 21 to 30 of about 46,730 (259)

Impact of N6-methyladenosine (m6A) modification on immunity

Cell Communication and Signaling, 2022
AbstractN6-methyl-adenosine (m6A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m6A relies on m6A writers, erasers and readers. m6A modification contributes to diverse fundamental biological functions at the molecular, cellular, and physiological levels.
Raghda A. Elsabbagh, Mona Rady, Carsten Watzl, Khaled Abou-Aisha, Mohamed Z. Gad   +4 more
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N6-Methyladenosine RNA Methylation in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine, 2022
N6-methyladenosine (m6A) modification is the most universal and abundant post-transcriptional modification of eukaryotic RNA and occurs mainly at the consensus motif RR (m6A) CH (R = A or G, H = A, C, or U) in long internal exons, near stop codons, or in the 3′ untranslated region (UTR).
Chi Liu, Chi Liu, Lei Gu, Wenjuan Deng, Qianchao Meng, Nan Li, Guifeng Dai, Suli Yu, Hong Fang   +8 more
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N6-methyladenosine RNA modification and its interaction with regulatory non-coding RNAs in colorectal cancer

, 2021
As one of the most common forms of RNA modification, N6-methyladenosine (m6A) RNA modification has attracted increasing research interest in recent years.
Lihong Yin (328532), Chuntao Wang (396544), Yiling Ge (11593672), Yiyi Ren (11593675), Tong Liu (107783), Yanqiu Zhang (4268377), Yuepu Pu (328530), Siyi Xu (1579693), Yanlu Feng (11593678), Geyu Liang (327126)   +9 more
core   +1 more source

Isothermal Amplification-Based Detection of Single-Base RNA N6-Methyladenosine

, 2023
N6-methyladenosine (m6A) has recently gained much attention due to its diverse biological functions. Currently, the commonly used detection methods for locus-specific m6A marks are complicated to operate, it is difficult to quantify the methylation level,
Cheng Yi (4502179), Jie Cao (353200), Guanmin Jiang (4007888), Weiling He (3394568), Lichen Ge (10122119), Hongsheng Wang (630465), Jiangli Zhou (17555721), Xianyuan Yang (17555724), Zigang Li (606370), Ke Zhong (7874111), You Wu (770287), Jiexin Li (6586130)   +11 more
core   +1 more source

N6 -Methyladenosine Negatively Regulates Human Respiratory Syncytial Virus Replication

Frontiers in Cell and Developmental Biology, 2021
N6-methyladenosine (m6A) is the most abundant internal modification described in eukaryotic mRNA and several viral RNA including human respiratory syncytial virus (HRSV).
Fabian Figueroa, Alonso Vega-Gibson, Joseline Catrileo, Aracelly Gaete-Argel, Aracelly Gaete-Argel, Sebastian Riquelme-Barrios, Sebastian Riquelme-Barrios, Luis Antonio Alonso-Palomares, Luis Antonio Alonso-Palomares, Lorena I. Tapia, Lorena I. Tapia, Fernando Valiente-Echeverría, Fernando Valiente-Echeverría, Ricardo Soto-Rifo, Ricardo Soto-Rifo, Monica L. Acevedo   +15 more
doaj   +1 more source

Table_5_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.XLSX

, 2021
The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439), Yue Shi (128342), Weimin Ci (4459504), Yanliang Dou (11472436), Yu Xiao (150812), Mingxin Zhang (4898947), Jie Qi (53195), Jianye Zhang (430972)   +7 more
core   +1 more source

Table_2_The RNA N6-Methyladenosine Methyltransferase METTL3 Promotes the Progression of Kidney Cancer via N6-Methyladenosine-Dependent Translational Enhancement of ABCD1.XLSX

, 2021
The role of N6-methyladenosine (m6A)-modifying proteins in cancer progression depends on the cell type and mRNA affected. However, the biological role and underlying mechanism of m6A in kidney cancer is limited. Here, we discovered the variability in m6A
Zijuan Xin (11472439), Yue Shi (128342), Weimin Ci (4459504), Yanliang Dou (11472436), Yu Xiao (150812), Mingxin Zhang (4898947), Jie Qi (53195), Jianye Zhang (430972)   +7 more
core   +1 more source

N6‐methyladenosine Steers RNA Metabolism and Regulation in Cancer

Cancer Communications, 2021
As one of the most studied ribonucleic acid (RNA) modifications in eukaryotes, N6‐methyladenosine (m6A) has been shown to play a predominant role in controlling gene expression and influence physiological and pathological processes such as oncogenesis ...
Shenghua Dong, Yutong Wu, Yadi Liu, Hengyou Weng, Huilin Huang   +4 more
doaj   +1 more source

FTO plays a crucial role in gastrointestinal cancer and may be a target for immunotherapy: an updated review

Frontiers in Oncology, 2023
Gastrointestinal cancer is a common malignancy with high mortality and poor prognosis. Therefore, developing novel effective markers and therapeutic targets for gastrointestinal cancer is currently a challenging and popular topic in oncology research ...
Xiangqing Ren, Xiangqing Ren, Xiangqing Ren, Xiaolong Tang, Tian Huang, Tian Huang, Tian Huang, Zenan Hu, Zenan Hu, Yuping Wang, Yuping Wang, Yongning Zhou, Yongning Zhou   +12 more
doaj   +1 more source

The role of N6-methyladenosine (m6A) in kidney diseases

Frontiers in Medicine, 2023
Chemical modifications are a specific and efficient way to regulate the function of biological macromolecules. Among them, RNA molecules exhibit a variety of modifications that play important regulatory roles in various biological processes. More than 170 modifications have been identified in RNA molecules, among which the most common internal ...
Luling You, Zhongyu Han, Haoran Chen, Liuyan Chen, Yumeng Lin, Binjian Wang, Yiyue Fan, Meiqi Zhang, Ji Luo, Fang Peng, Yue Ma, Yanmei Wang, Lan Yuan, Zhongyu Han   +13 more
openaire   +3 more sources