Results 51 to 60 of about 53,902 (279)

ZFP36L1 Enhances Microglial Ferroptosis in Ischemic Stroke by Reducing FTO-Mediated N6-Methyladenosine Demethylation of ACSL1 mRNA. [PDF]

Kaohsiung J Med Sci
ABSTRACT Microglia play an important role in ischemic stroke (IS). However, the molecular regulatory mechanisms underlying microglial ferroptosis in IS remain incompletely understood. In this study, blood samples were collected from 20 IS patients and 15 healthy volunteers.
Song AX, Jin HX, Sun YX, Kou WH, Niu XN, Wang HH, Zhong TT, Gu P.   +7 more
europepmc   +2 more sources

Data_Sheet_2_Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer.ZIP

, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Haoran Xia (7062632), Jianye Wang (453856), Zhengtong Lv (10146227), Wei Zhang (405), Lingfeng Meng (2576632), Meng Wu (191457), Yaoguang Zhang (746651), Jianlong Wang (438075), Jiawen Wang (350508), Jingchao Liu (2051245)   +9 more
core   +1 more source

N6-Methyladenosine Role in Acute Myeloid Leukaemia [PDF]

International Journal of Molecular Sciences, 2018
We are currently assisting in the explosion of epitranscriptomics, which studies the functional role of chemical modifications into RNA molecules. Among more than 100 RNA modifications, the N6-methyladenosine (m6A), in particular, has attracted the interest of researchers all around the world.
Ianniello, Zaira, Fatica, Alessandro
openaire   +3 more sources

N6-methyladenosine modification regulates cell death in cognitive impairment

Neural Regeneration Research
Neurodegenerative diseases are characterized by a decline in brain structure and function. Their pathology involves multiple cell death pathways, including ferroptosis, cuproptosis, and pyroptosis.
Yiqun Li, Yuxin Zhang, Yanzhen Wang, Ke Ye, Lulu Liu, Mengjie Tian, Xinyu Han, Xinyi Chen, Tianhu Zheng, Fuyuan Li, Xu Gao, Qing Xia, Dayong Wang   +12 more
doaj   +1 more source

The importance of N6-methyladenosine modification in tumor immunity and immunotherapy

Experimental Hematology & Oncology, 2022
As the most common and abundant RNA modification in eukaryotic cells, N6-methyladenosine (m6A) modification plays an important role in different stages of tumor.
Ze Zhang, Furong Liu, Wei Chen, Zhibin Liao, Wanguang Zhang, Bixiang Zhang, Huifang Liang, Liang Chu, Zhanguo Zhang   +8 more
doaj   +1 more source

EBV Exploits RNA m6A Modification to Promote Cell Survival and Progeny Virus Production During Lytic Cycle

Frontiers in Microbiology, 2022
N6-methyladenosine (m6A) mediates various biological processes by affecting RNA stability, splicing, and translational efficiency. The roles of m6A modification in Epstein-Barr virus (EBV) infection in the lytic phase are unclear.
Yusuke Yanagi, Takahiro Watanabe, Yuya Hara, Yoshitaka Sato, Hiroshi Kimura, Takayuki Murata, Takayuki Murata   +6 more
doaj   +1 more source

Data_Sheet_3_Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer.ZIP

, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Haoran Xia (7062632), Jianye Wang (453856), Zhengtong Lv (10146227), Wei Zhang (405), Lingfeng Meng (2576632), Meng Wu (191457), Yaoguang Zhang (746651), Jianlong Wang (438075), Jiawen Wang (350508), Jingchao Liu (2051245)   +9 more
core   +1 more source

N6-Methyladenosine-Modified ATP8B1-AS1 Exerts Oncogenic Roles in Hepatocellular Carcinoma via Epigenetically Activating MYC

, 2023
Chuan Tan,1,* Yanyan Huang,2,* Zheng Huang,2,* Yuanjia Ning,2 Lizheng Huang,2 Xianjian Wu,1 Yuan Lu,1 Huamei Wei,3 Jian Pu1 1Department of Hepatobiliary Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise ...
Huang Y, Huang Z, Lu Y, Ning Y, Tan C, Pu J, Wei H, Huang L, Wu X   +8 more
core  

Data_Sheet_10_Comprehensive Analysis of N6-methyladenosine Modification Patterns Associated With Multiomic Characteristics of Bladder Cancer.zip

, 2021
Purpose: To comprehensively analyze N6-methyladenosine modification patterns in bladder tumors and to further systematically explore the inherent relationships between these modification patterns and multiomic tumor characteristics.Materials and Methods:
Haoran Xia (7062632), Jianye Wang (453856), Zhengtong Lv (10146227), Wei Zhang (405), Lingfeng Meng (2576632), Meng Wu (191457), Yaoguang Zhang (746651), Jianlong Wang (438075), Jiawen Wang (350508), Jingchao Liu (2051245)   +9 more
core   +1 more source

Neuromodulatory role and therapeutic potential of N6-methyladenosine RNA methylation in neurodegenerative diseases

Neural Regeneration Research
N6-methyladenosine RNA methylation, an essential post-transcriptional modification, dynamically regulates RNA metabolism and plays a crucial role in neuronal function.
Jinyu Zhang, Wenjing Ma, Ranxu Liu, Xiaoheng Li, Zengqiang Yuan, Jinbo Cheng   +5 more
doaj   +1 more source