RNA Splicing Factors and RNA-Directed DNA Methylation [PDF]
Biology, 2014 RNA-directed histone and/or DNA modification is a conserved mechanism for the establishment of epigenetic marks from yeasts and plants to mammals. The heterochromation formation in yeast is mediated by RNAi-directed silencing mechanism, while the establishment of DNA methylation in plants is through the RNA-directed DNA methylation (RdDM) pathway ...
Chao-Feng Huang, Jian-Kang Zhu
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Detecting m6A methylation regions from Methylated RNA Immunoprecipitation Sequencing
Bioinformatics, 2021 AbstractMotivationThe post-transcriptional epigenetic modification on mRNA is an emerging field to study the gene regulatory mechanism and their association with diseases. Recently developed high-throughput sequencing technology named Methylated RNA Immunoprecipitation Sequencing (MeRIP-seq) enables one to profile mRNA epigenetic modification ...
Zhenxing Guo +4 more
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Insights into the role of DNA methylation in diatoms by genome-wide profiling in Phaeodactylum tricornutum [PDF]
, 2013 DNA cytosine methylation is a widely conserved epigenetic mark in eukaryotes that appears to have critical roles in the regulation of genome structure and transcription.
Ahmed, Ikhlak +21 more
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RNA Methylation in Systemic Lupus Erythematosus
Frontiers in Cell and Developmental Biology, 2021 Systemic lupus erythematosus (SLE) is an autoimmune disease with complicated clinical manifestations. Although our understanding of the pathogenesis of SLE has greatly improved, the understanding of the pathogenic mechanisms of SLE is still limited by ...
Xinyi Lv +6 more
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Trisomy 21 alters DNA methylation in parent-of-origin-dependent and independent manners [PDF]
, 2016 The supernumerary chromosome 21 in Down syndrome differentially affects the methylation statuses at CpG dinucleotide sites and creates genome-wide transcriptional dysregulation of parental alleles, ultimately causing diverse pathologies.
Alves da Silva, Antônio Francisco +12 more
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Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain [PDF]
Open Biology, 2017 N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite the relatively high m6A levels in the brain, its potential functions in the brain remain largely ...
Mengqi Chang +10 more
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Reading RNA methylation codes through methyl-specific binding proteins [PDF]
RNA Biology, 2014 N (6)-methyladenosine (m (6)A) is a prevalent modification of eukaryotic mRNAs. It regulates yeast cell fate and is essential to the development and fertility of metazoans. Although its presence in mRNA has been known since the early 1970s, the function of m (6)A remained a mystery until the spate of discoveries in the past three years.
Xiao, Wang, Chuan, He
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Loss of Endometrial Plasticity in Recurrent Pregnancy Loss [PDF]
, 2015 © 2015 AlphaMed Press.Menstruation drives cyclic activation of endometrial progenitor cells, tissue regeneration, and maturation of stromal cells, which differentiate into specialized decidual cells prior to and during pregnancy.
Brighton, PJ +15 more
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The 2HA line of Medicago truncatula has characteristics of an epigenetic mutant that is weakly ethylene insensitive [PDF]
, 2016 BACKGROUND The Medicago truncatula 2HA seed line is highly embryogenic while the parental line Jemalong rarely produces embryos. The 2HA line was developed from one of the rare Jemalong regenerates and this method for obtaining a highly regenerable ...
Carroll, Bernard J +6 more
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The role of mRNA m6A methylation in the nervous system
Cell & Bioscience, 2019 Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (
Jiashuo Li +8 more
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