Results 41 to 50 of about 1,130,807 (299)

Transcription influences repair-induced DNA methylation [PDF]

, 2008
This work is aimed at the dissection of the molecular mechanism(s) linking DNA damage and gene silencing. To this end, we have developed a genetic system that allows a rapid assessment of homologous-directed repair (HR) of an unique DNA double strand ...
Morano, Annalisa
core   +1 more source

Apoptosis and DNA methylation [PDF]

, 2011
Epigenetic mechanisms assist in maintaining gene expression patterns and cellular properties in developing and adult tissues. The molecular pathology of disease states frequently includes perturbation of DNA and histone methylation patterns, which can ...
Meng, Huan X, Nestor, Colm, Reddington, James P, Richard R. Meehan, Harrison, David J, Dunican, Donncha S, Monika Madej, Hackett, James A, Dunican, Donncha S; id_orcid, James P. Reddington, Madej, Monika, Colm Nestor, Sari Pennings, Meehan, Richard R, Pennings, Sari, James A. Hackett, Huan X. Meng, David J. Harrison, Donncha S. Dunican   +18 more
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RNA Methylation in Systemic Lupus Erythematosus

Frontiers in Cell and Developmental Biology, 2021
Systemic lupus erythematosus (SLE) is an autoimmune disease with complicated clinical manifestations. Although our understanding of the pathogenesis of SLE has greatly improved, the understanding of the pathogenic mechanisms of SLE is still limited by ...
Xinyi Lv, Xiaomin Liu, Ming Zhao, Haijing Wu, Wuiguang Zhang, Qianjin Lu, Xiangmei Chen   +6 more
doaj   +1 more source

Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain [PDF]

Open Biology, 2017
N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite the relatively high m6A levels in the brain, its potential functions in the brain remain largely ...
Mengqi Chang, Hongyi Lv, Weilong Zhang, Chunhui Ma, Xue He, Shunli Zhao, Zhi-Wei Zhang, Yi-Xin Zeng, Shuhui Song, Yamei Niu, Wei-Min Tong   +10 more
doaj   +1 more source

DNA methylation in chromatin - complexes and mechanisms [PDF]

, 2010
The DNA in the eukaryotic genome is packaged into chromatin whose basic repeating unit is the nucleosome consisting of 147bp of DNA wrapped around an octameric histone core.
Felle, Max
core   +1 more source

Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages [PDF]

, 2015
Date of Acceptance: 02/01/2015Small RNA pathways act at the front line of defence against transposable elements across the Eukaryota. In animals, Piwi interacting small RNAs (piRNAs) are a crucial arm of this defence.
Jones, John T., Murray E Selkirk, John T Jones, Goldstein, R, Phillip M. Schiffer (691095), Bob Goldstein, Miska, E A, Taylor, Mark J., Eric A. Miska (41828), Blaxter, Mark L., Murray E. Selkirk (202480), Miska, Eric A., Christopher Kraus (691096), John T. Jones (207247), Fast, Naomi M., Sarkies, P, Peter Sarkies (691090), Alex Ardila-Garcia, Ben Hanelt (107535), Blok, V, Schiffer, Phillip M., Georgios Koutsovoulos (556628), Hanelt, Ben, Georgios Koutsovoulos, Boothby, Thomas, Ben Hanelt, Naomi M. Fast (691094), Koutsovoulos, Georgios, Mark J Taylor, Bob Goldstein (265221), Selkirk, Murray E., Phillip M Schiffer, Ardila-Garcia, Alex, Eric A Miska, Alex Ardila-Garcia (691093), Thomas Boothby, Hanelt, B, Mark J. Taylor (118298), Thomas Boothby (691092), Mark L. Blaxter (115482), Selkirk, M E, Vivian Blok (691091), Blok, Vivian, Naomi M Fast, Taylor, Mark; id_orcid, Kraus, C, Schiffer, P M, Sarkies, Peter, Jones, J T, Goldstein, Bob, Fast, N M, Christopher Kraus, Koutsovoulos, G, Taylor, M J, Ardila-Garcia, A, Mark L Blaxter, Kraus, Christopher, Blaxter, M L, Boothby, T, Peter Sarkies, Vivian Blok   +60 more
core   +2 more sources

The role of mRNA m6A methylation in the nervous system

Cell & Bioscience, 2019
Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (
Jiashuo Li, Xinxin Yang, Zhipeng Qi, Yanqi Sang, Yanan Liu, Bin Xu, Wei Liu, Zhaofa Xu, Yu Deng   +8 more
doaj   +1 more source

Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop

Journal of Ginseng Research, 2021
Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer.
Chunmei Hu, Linhan Yang, Yi Wang, Shijie Zhou, Jing Luo, Yi Gu   +5 more
doaj   +1 more source

Multiple functions of m6A RNA methylation in cancer

Journal of Hematology & Oncology, 2018
First identified in 1974, m6A RNA methylation, which serves as a predominant internal modification of RNA in higher eukaryotes, has gained prodigious interest in recent years. Modifications of m6A are dynamic and reversible in mammalian cells, which have
Yutian Pan, Pei Ma, Yu Liu, Wei Li, Yongqian Shu   +4 more
doaj   +1 more source

The potential regulatory role of RNA methylation in ovarian cancer

RNA Biology, 2023
Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao, Mengxue Zhang, Xiaolan Zhu, Jie Xing, Jiaming Zhou, Xinming Yin   +5 more
doaj   +1 more source