Results 41 to 50 of about 248,618 (295)
Integration of multi-omics data reveals dysregulated RNA methylation in retinal pigment epithelium drives age-related macular degeneration [PDF]
International Journal of OphthalmologyAIM: To investigate the role of RNA methylation in retinal pigment epithelial (RPE) cells in age-related macular degeneration (AMD). METHODS: RNA methylation-related gene expression profiles of AMD patient and normal control retinal pigment epithelium ...
Ya-Jun Gong +4 more
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2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase. [PDF]
PLoS Pathogens, 2012 RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2'-O methyltransferase activities that are required for the formation of 5' type I cap (m(7)GpppAm) of viral RNA genome.
Hongping Dong +10 more
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RNA Methylation in Systemic Lupus Erythematosus
Frontiers in Cell and Developmental Biology, 2021 Systemic lupus erythematosus (SLE) is an autoimmune disease with complicated clinical manifestations. Although our understanding of the pathogenesis of SLE has greatly improved, the understanding of the pathogenic mechanisms of SLE is still limited by ...
Xinyi Lv +6 more
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Region-specific RNA m6A methylation represents a new layer of control in the gene regulatory network in the mouse brain [PDF]
Open Biology, 2017 N6-methyladenosine (m6A) is the most abundant epitranscriptomic mark found on mRNA and has important roles in various physiological processes. Despite the relatively high m6A levels in the brain, its potential functions in the brain remain largely ...
Mengqi Chang +10 more
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The role of mRNA m6A methylation in the nervous system
Cell & Bioscience, 2019 Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery following the deoxyribonucleic acid (DNA) and histone methylation. Messenger RNA (
Jiashuo Li +8 more
doaj +1 more source
Frontiers in Pharmacology, 2022 N6-methyladenosine (m6A) RNA methylation has been considered the most prevalent, abundant, and conserved internal transcriptional modification throughout the eukaryotic mRNAs.
Zhaolin Chen +7 more
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The potential regulatory role of RNA methylation in ovarian cancer
RNA Biology, 2023 Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao +5 more
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Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop
Journal of Ginseng Research, 2021 Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer.
Chunmei Hu +5 more
doaj +1 more source
Molecular Oncology, 2022 N6‐methyladenosine (m6A) is one of the most abundant internal modifications in eukaryotic messenger RNAs (mRNAs) and non‐coding RNAs (ncRNAs). It is a reversible and dynamic RNA modification that has been observed in both internal coding segments and untranslated regions.
Zhaotong Wang +5 more
openaire +3 more sources
The role m6A RNA methylation is CNS development and glioma pathogenesis
Molecular Brain, 2021 Epigenetic abnormalities play a crucial role in many tumors, including glioma. RNA methylation occurs as an epigenetic modification similar to DNA methylation and histone modification.
Ting Pan +7 more
doaj +1 more source