Results 61 to 70 of about 1,130,807 (299)

Comprehensive Structural and Substrate Specificity Classification of the Saccharomyces cerevisiae Methyltransferome [PDF]

, 2011
Methylation is one of the most common chemical modifications of biologically active molecules and it occurs in all life forms. Its functional role is very diverse and involves many essential cellular processes, such as signal transduction ...
Kudlicki, Andrzej, Wlodarski Tomasz, Maga Rowicka, Rowicka Maga, Kudlicki Andrzej, Ginalski, Krzysztof, Rychlewski Leszek, Dziembowski, Andrzej, Rychlewski, Leszek, Ginalski Krzysztof, Joanna Towpik, Dziembowski Andrzej, Andrzej Kudlicki, Kutner, Jan, Andrzej Dziembowski, Knizewski Lukasz, Lukasz Knizewski, Leszek Rychlewski, Wlodarski, Tomasz, Jan Kutner, Knizewski, Lukasz, Towpik, Joanna, Towpik Joanna, Rowicka, Magda, Kutner Jan, Krzysztof Ginalski, Tomasz Wlodarski   +26 more
core   +3 more sources

m6A RNA Methylation Regulators Contribute to Malignant Progression and Have Clinical Prognostic Impact in Gastric Cancer

Frontiers in Oncology, 2019
N6-methyladenosine (m6A) is the most common form of mRNA modification, and is dynamically regulated by the m6A RNA methylation regulators. However, little is known about m6A in gastric cancer. The aim of this work is to investigate the effects of m6A RNA
Yunshu Su, Jinqi Huang, Jichang Hu
doaj   +1 more source

RNA Splicing Factors and RNA-Directed DNA Methylation [PDF]

Biology, 2014
RNA-directed histone and/or DNA modification is a conserved mechanism for the establishment of epigenetic marks from yeasts and plants to mammals. The heterochromation formation in yeast is mediated by RNAi-directed silencing mechanism, while the establishment of DNA methylation in plants is through the RNA-directed DNA methylation (RdDM) pathway ...
Chao-Feng Huang, Jian-Kang Zhu
openaire   +3 more sources

Regulation of heterochromatic RNA decay via heterochromatin protein 1 (HP1) [PDF]

, 2012
The central dogma of molecular biology describes the directional flow of biological information from DNA via RNA to protein. Information stored in DNA is copied to an mRNA molecule during the process of transcription.
Keller, Claudia Isabelle
core   +1 more source

A DNA target of 30 bp is sufficient for RNA-directed DNA methylation

, 2022
S.55-65In higher plants, RNA-DNA interactions can trigger de novo methylation of genomic sequences via a process that is termed RNA-directed DNA methylation (RdDM).
Pelissier, T., Wassenegger, M.
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Clinical significance of RNA methylation in hepatocellular carcinoma

Cell Communication and Signaling
Hepatocellular carcinoma (HCC) is a primary liver malignancy with high mortality rates and poor prognosis. Recent advances in high-throughput sequencing and bioinformatic technologies have greatly enhanced the understanding of the genetic and epigenetic ...
Qiongling Bao, Yifan Zeng, Qizhuo Lou, Xuewen Feng, Shuwen Jiang, Juan Lu, Bing Ruan   +6 more
doaj   +1 more source

Using integrated analysis from multicentre studies to identify RNA methylation-related lncRNA risk stratification systems for glioma

Cancer Cell International, 2023
Background N6-methyladenosine (m6A), 5-methylcytosine (m5C) and N1-methyladenosine (m1A) are the main RNA methylation modifications involved in the progression of cancer.
Fanxuan Huang, Xinyu Wang, Junzhe Zhong, Hao Chen, Dan Song, Tianye Xu, Kaifu Tian, Penggang Sun, Nan Sun, Jie Qin, Yu Song, Wenbin Ma, Yuxiang Liu, Daohan Yu, Xiangqi Meng, Chuanlu Jiang, Hanwen Xuan, Da Qian, Jinquan Cai   +18 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Critical roles and clinical perspectives of RNA methylation in cancer

MedComm
RNA modification, especially RNA methylation, is a critical posttranscriptional process influencing cellular functions and disease progression, accounting for over 60% of all RNA modifications. It plays a significant role in RNA metabolism, affecting RNA
Ganglei Li, Qinfan Yao, Peixi Liu, Hongfei Zhang, Yingjun Liu, Sichen Li, Yuan Shi, Zongze Li, Wei Zhu   +8 more
doaj   +1 more source