Results 1 to 10 of about 13,010 (203)
m1A Post‐Transcriptional Modification in tRNAs [PDF]
Biomolecules, 2017 To date, about 90 post‐transcriptional modifications have been reported in tRNA expanding their chemical and functional diversity. Methylation is the most frequent post‐transcriptional tRNA modification that can occur on almost all nitrogen sites of
Carine Tisné +2 more
exaly +6 more sources
M1a prostate cancer: Results of a Dutch multidisciplinary consensus meeting [PDF]
BJUI Compass, 2021 Objectives To determine the consensus of a Dutch multidisciplinary expert panel on the diagnostic evaluation and treatment of de novo and recurrent metastatic prostate cancer (PCa) limited to non‐regional lymph nodes (M1a) in daily clinical practice ...
Shafak Aluwini +7 more
doaj +4 more sources
Harnessing m1A modification: a new frontier in cancer immunotherapy [PDF]
Frontiers in ImmunologyN1-methyladenosine (m1A) modification is an epigenetic change that occurs on RNA molecules, regulated by a suite of enzymes including methyltransferases (writers), demethylases (erasers), and m1A-recognizing proteins (readers).
Xinru Wang +10 more
doaj +4 more sources
Landscape of N1-methyladenosin (m1A) modification pattern in colorectal cancer
Cancer Reports, 2023 Background N1‐methyladenosine (m1A) is a recently identified mRNA modification. However, it is still unclear that how m1A alteration affects the development of colorectal cancer (CRC).
Lei Gu, Chunjie Xu, Chunhui Jiang
exaly +4 more sources
Frontiers in Immunology, 2022 RNA modification of m6A/m5C/m1A contributes to the occurrence and development of cancer. Consequently, this study aimed to investigate the functions of m6A/m5C/m1A regulated genes in the prognosis and immune microenvironment of hepatocellular carcinoma ...
Di Ke, Kong-Wu Yang
exaly +4 more sources
OncoImmunology, 2021 Emerging evidence has revealed the crucial role of transcriptional RNA methyladenosine modification in immune response. However, the potential role of RNA N1-methyladenosine (m1A) modification of immune cells in the tumor microenvironment (TME) still ...
Yu-Zhen Gao, Liangjing Wang, Xinyou Xie
exaly +2 more sources
Frontiers in Immunology, 2022 RNA methylation plays crucial roles in gene expression and has been indicated to be involved in tumorigenesis, while it is still unclear whether m1A modifications have potential roles in the prognosis of hepatocellular carcinoma (HCC).
Chen Xue, Shen Shen
exaly +3 more sources
Validation of the mRNA epitranscriptome: SCARPET reveals that mapped m1A sites are inosine [PDF]
EMBO ReportsA major goal in epitranscriptomics is to define the diversity of modified nucleotides in mRNA. Most candidate sites are discovered using transcriptome-wide mapping methods that rely on antibody enrichment or modification-induced misincorporations during ...
Rohit Nalavade +2 more
doaj +2 more sources
Effect of M1a and M1b category in metastatic colorectal cancer. [PDF]
Oncologist, 2014 Abstract Background. In 2009, the American Joint Committee on Cancer version 7 staging system introduced the M1 subclassifications M1a (single metastatic site) and M1b (peritoneal or multiple metastatic sites). The study objectives were to evaluate the prognostic effect of site of metastasis and M1a/b
Hagen Kennecke +2 more
exaly +3 more sources
m1A and m6A modifications function cooperatively to facilitate rapid mRNA degradation
Cell Reports, 2022 N6-Methyladenosine (m6A), the most abundant internal mRNA modification, affects multiple steps in gene expression. Mechanistically, the binding of YTHDF2 to m6A on mRNAs elicits rapid mRNA degradation by recruiting several RNA degrading enzymes. Here, we show that N1-methyladenosine (m1A), another type of RNA modification, accelerates rapid m6A RNA ...
Yoon Ki Kim, Hongseok Ha, Sung Ho Boo
exaly +3 more sources