Results 1 to 10 of about 14,453 (241)

The m6A/m5C/m1A Regulated Gene Signature Predicts the Prognosis and Correlates With the Immune Status of Hepatocellular Carcinoma [PDF]

Frontiers in Immunology, 2022
RNA modification of m6A/m5C/m1A contributes to the occurrence and development of cancer. Consequently, this study aimed to investigate the functions of m6A/m5C/m1A regulated genes in the prognosis and immune microenvironment of hepatocellular carcinoma ...
Dan Li, Dan Li, Kai Li, Wei Zhang, Kong-Wu Yang, De-An Mu, Guo-Jun Jiang, Rong-Shu Shi, Di Ke, Di Ke   +9 more
exaly   +5 more sources

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis [PDF]

Advanced Science
N1‐methyladenosine (m1A) modification widely occurs in various RNAs, yet its pathophysiological function in tumorigenesis remains poorly understood. Notably, the expression and biological roles of tRNA m1A methyltransferase 6 noncatalytic subunit (TRMT6)
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
doaj   +3 more sources

Comprehensive Analysis of the Function, Immune Profiles, and Clinical Implication of m1A Regulators in Lung Adenocarcinoma

Frontiers in Oncology, 2022
BackgroundPrevious studies have demonstrated that transcriptional RNA methyladenosine modification significantly affects tumor initiation and progression.
Guangyao Bao, Xiaojiao Guan, Xinwen Zhong   +2 more
exaly   +3 more sources

The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons

eLife, 2023
Cerebral ischaemia‒reperfusion injury (IRI), during which neurons undergo oxygen-glucose deprivation/reoxygenation (OGD/R), is a notable pathological process in many neurological diseases.
Chi Zhang, Xianfu Yi, Mengfan Hou, Qingyang Li, Xueying Li, Lu Lu, Enlin Qi, Mingxin Wu, Lin Qi, Huan Jian, Zhangyang Qi, Yigang Lv, Xiaohong Kong, Mingjun Bi, Shiqing Feng, Hengxing Zhou   +15 more
doaj   +2 more sources

Integrated analyses of m 1 A regulator-mediated modification patterns in tumor microenvironment-infiltrating immune cells in colon cancer

OncoImmunology, 2021
Emerging evidence has revealed the crucial role of transcriptional RNA methyladenosine modification in immune response. However, the potential role of RNA N1-methyladenosine (m1A) modification of immune cells in the tumor microenvironment (TME) still ...
Yuzhen Gao, Shijin Yuan, Xinyou Xie
exaly   +2 more sources

TRMT6-directed m1A modification initiates lung squamous cell carcinoma via YTHDF3-stabilized cell cycle genes [PDF]

npj Precision Oncology
N1-Methyladenosine (m1A) is a prevalent RNA modification that governs RNA metabolism, structure, stability, and translation. Yet its cancer-wide landscape and functional impact remain largely unexplored.
Weihao Xue, Liqiang Zhu, Xiaolong Wei, Jinqi Sun, Weihao Lin, Shaomin Huang, Lianpin Wu, Donghong Zhang   +7 more
doaj   +2 more sources

A Novel m1A-Score Model Correlated With the Immune Microenvironment Predicts Prognosis in Hepatocellular Carcinoma

Frontiers in Immunology, 2022
RNA methylation plays crucial roles in gene expression and has been indicated to be involved in tumorigenesis, while it is still unclear whether m1A modifications have potential roles in the prognosis of hepatocellular carcinoma (HCC).
Mingxing Zhao, Shen Shen, Chen Xue
exaly   +3 more sources

m1A inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling

International Journal of Oral Science
N 1-methyladenosine (m1A) RNA methylation is critical for regulating mRNA translation; however, its role in the development, progression, and immunotherapy response of head and neck squamous cell carcinoma (HNSCC) remains largely unknown.
Shujin Li, Tian Feng, Yuantong Liu, Qichao Yang, An Song, Shuo Wang, Jun Xie, Junjie Zhang, Bifeng Yuan, Zhijun Sun   +9 more
doaj   +2 more sources

Identification and validation of an m1A-score model to predict outcomes and immunomodulation in lung squamous cell carcinoma by integrated analysis of single-cell and bulk RNA sequencing [PDF]

Discover Oncology
Lung squamous cell carcinoma (LUSC) is a common and aggressive subtype of lung cancer, characterized by difficult treatment and poor prognosis. N1-methyladenosine (m1A) is an RNA modification that plays a crucial role in various biological processes ...
Han Gong, Haihang Zhang, Lin Zhu, Jing Liu, Dehui Xiong, Yibin Zhang   +5 more
doaj   +2 more sources

RNA m 1 A methylation regulates glycolysis of cancer cells through modulating ATP5D

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance The functions of N1-methyladenosine (m1A) in cancer development were largely unknown. We revealed m1A can positively regulate the glycolysis of cancer cells via regulation of ATP5D. Specifically, m1A regulates translation of ATP5D via YTHDF1/
Zhuojia Chen, Zhaotong Wang, Likun Chen   +2 more
exaly   +2 more sources