Results 21 to 30 of about 13,010 (203)

The landscape of N1-methyladenosine (m1A) modification in mRNA of the decidua in severe preeclampsia [PDF]

Biomolecules & Biomedicine
Recent discoveries in mRNA modification have highlighted N1-methyladenosine (m1A), but its role in preeclampsia (PE) pathogenesis remains unclear. In this study, we utilized methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing ...
Jing Tong, Hua Li, Liang Zhang, Cong Zhang   +3 more
doaj   +2 more sources

Abundant mRNA m1A modification in dinoflagellates: a new layer of gene regulation

EMBO Reports
Dinoflagellates, a class of unicellular eukaryotic phytoplankton, exhibit minimal transcriptional regulation, representing a unique model for exploring gene expression.
Chongping Li, Ying Li, Jia Guo, Yuci Wang, Xiaoyan Shi, Yangyi Zhang, Nan Liang, Honghui Ma, Jie Yuan, Jiawei Xu, Hao Chen   +10 more
doaj   +2 more sources

TRMT6‐Mediated m1A Modification of CDK9 mRNA is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma [PDF]

Advanced Science
Hepatocellular carcinoma (HCC) is a leading cause of death worldwide, with hepatitis B virus (HBV) infection being the major risk factor. Dysregulation of mRNA methylation contributes to tumorigenesis and virus replication. However, the association of N1‐
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
doaj   +2 more sources

Dinoflagellate mRNA is pervasively modified with m1A

EMBO Reports
N(1)-methyladenosine (m(1)A) is a very rare RNA modification in mammalian mRNA, which occurs in sequences resembling the T-loop of tRNAs and may not have significant effects on gene expression. A new study in this issue now reports that m(1)A is abundant and dynamic in the 3′UTR of mRNAs of dinoflagellates, and could have an important role in post ...
Jianheng Fox Liu, Samie R Jaffrey
openaire   +3 more sources

THGC_MDA: a method for predicting the associations between m1A modification and diseases based on ternary heterogeneous network and graph convolutional neural network [PDF]

Frontiers in Genetics
m1A modification, as a pivotal RNA epigenetic modification, plays a central regulatory role in the pathogenesis and progression of complex human diseases, including cancer.
Hongyan Gao, Xue Zhou, Lei Bai, Haifeng Yang, Fei Liu   +4 more
doaj   +2 more sources

Different prognosis of patients with esophageal carcinoma with M1a and regional node involvement

Digestive and Liver Disease, 2019
Based on the 6th edition of the American Joint Commission on Cancer (AJCC) staging system for esophageal squamous cell carcinoma (ESCC), M1a node involvement was classified as regional node involvement in the revised 7th/8th edition. However, the clinical significance of M1a node involvement is unclear.
Tae Ryong, Chung, Jie-Hyun, Kim, Ik Jae, Lee, Yeona, Cho, Jun Won, Kim, Chang Geol, Lee, Da Hyun, Jung, Jae Jun, Park, Young Hoon, Youn, Hyojin, Park   +9 more
openaire   +4 more sources

TRMT61A‐Mediated m1A Modification Suppresses FDX1 Translation to Drive Cuproptosis Evasion and Radioresistance in Hepatocellular Carcinoma

MedComm – Oncology
Radioresistance remains a major obstacle to the curative treatment of hepatocellular carcinoma (HCC). While cuproptosis represents a potential strategy to eliminate resistant cells, the epitranscriptomic mechanisms underlying cuproptosis evasion remain ...
Yunyun Xiao, Yue Li, Zelei Li, Rui Wang, Dongni Shi, Yanling Wen, Yibing Pan, Chen Lin, Junguo Bu, Libing Song, Hui Dai   +10 more
doaj   +2 more sources

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid-β Pathology. [PDF]

Adv Sci (Weinh)
ABSTRACT Amyloid‐beta (Aβ) aggregation, mitochondrial dysfunction, and cognitive decline are hallmarks of Alzheimer's disease (AD), but its initiating molecular events remain unknown. Given that RNA modifications regulate neurodevelopment and neurodegeneration, we explore their functional role in 5xFAD mice, an Aβ
Li Y, Yu S, Lu K, Zhang Y, Dong M, Peng Y, Xue L, Alam W, Shui Y, Zhou Y, Ma W, Bao M, Li P, Luo P, Lu T, Li J, Zhang K, Wang Y, Yang S, Yin N, Faiola F, Gao Z, Zhou J, Zhao F, He Y, Koziol MJ.   +25 more
europepmc   +3 more sources

Identification and functional characterization of m1A-related genes in colorectal cancer: implications for prognosis, immune infiltration, and therapeutic strategies [PDF]

Frontiers in Oncology
IntroductionColorectal cancer (CRC), characterized by its complex genetic heterogeneity and varied responses to treatment, is a leading cause of cancer-related mortality worldwide.
Lan Sun, Liwei Huangfu, Fang Li, Yuhui Yan, Ruiping Kong, Kun Ji, Jiachun Li   +6 more
doaj   +2 more sources

M1A

, 2021
Tape M1A Mandailing – Recorded 28/8/80 •Gendang •Gordang Sembilan •Sirih Dance •(Practice) Music includes percussion (drums, clappers, cymbals gongs, etc.), shawm and sections with particularly energetic drumming. Tracks not numbered in notes.
Traditional Musicians (11720099), Lynette Moore (11720102)   +1 more
core   +2 more sources