Results 21 to 30 of about 26,465 (226)

m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma [PDF]

BMC Gastroenterology, 2022
Background The dysregulation of RNA methylation has been demonstrated to contribute to tumorigenicity and progression in recent years. However, the alteration of N1-methyladenosine (m1A) methylation and its role in hepatocellular carcinoma (HCC) remain ...
Chengcheng Tong, Wei Wang, Chiyi He
doaj   +3 more sources

Antibody cross-reactivity accounts for widespread appearance of m1A in 5’UTRs

Nature Communications, 2019
N 1-methyladenosine (m1A) was recently reported as a new mRNA modification but its prevalence has been controversial. Here the authors showed that m1A, if present in mRNA, is at very low stoichiometry, with the notable exception of MT-ND5.
Anya V Grozhik, Anthony O Olarerin-George, Xing Li   +2 more
exaly   +2 more sources

Landscape of N1‐methyladenosin (m1A) modification pattern in colorectal cancer

Cancer Reports, 2023
Background N1‐methyladenosine (m1A) is a recently identified mRNA modification. However, it is still unclear that how m1A alteration affects the development of colorectal cancer (CRC).
Chunhui Jiang, Yuan Tian, Chunjie Xu, Hao Zhang, Lei Gu   +4 more
doaj   +3 more sources

How reliable is M1A? [PDF]

, 1987
Monetary policy - United States ; Money ...
Bharat Trehan, John P. Judd
core   +1 more source

m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA

Cell & Bioscience
Background N1-Methyladenosine (m1A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the characteristics and biological functions of mRNA m1A modification in adult hippocampal neurogenesis remain ...
Huan Wang, Linjie Xie, Haomin Guo, Lishi Li, Shuwei Chen, Ye Fan, Jingyuan Tian, Liping Xu, Xuejian Kong, Aiguo Xuan   +9 more
doaj   +3 more sources

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis [PDF]

Advanced Science
N1‐methyladenosine (m1A) modification widely occurs in various RNAs, yet its pathophysiological function in tumorigenesis remains poorly understood. Notably, the expression and biological roles of tRNA m1A methyltransferase 6 noncatalytic subunit (TRMT6)
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
doaj   +2 more sources

RNA m1A methyltransferase TRMT61A promotes colorectal tumorigenesis by enhancing ONECUT2 mRNA stability and is a potential therapeutic target [PDF]

Cancer Communications
Background The role of N1‐methyladenosine (m1A) in cancer is poorly understood. Here we explored the function of RNA methyltransferase TRNA methyltransferase 61A (TRMT61A) in colorectal cancer (CRC) and its potential as a therapeutic target.
Xiaoting Zhang, Na Qin, Fenfen Ji, Hao Su, Haiyun Shang, Hongyan Chen, Dan Huang, Qing Li, Jing Ren, Weixin Liu, Yifei Wang, Wei Kang, Jiabin Wu, Chi‐Chun Wong, Zongwei Cai, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu, Huarong Chen   +18 more
doaj   +2 more sources

Comprehensive analyses of m1A regulator-mediated modification patterns determining prognosis in lower-grade glioma (running title: m1A in LGG)

Heliyon
N1-methyladenosine (m1A) modification is a crucial post-transcriptional regulatory mechanism of messenger RNA (mRNA) in living organisms. Few studies have focused on analysis of m1A regulators in lower-grade gliomas (LGG).
Kunjian Lei, Yilei Sheng, Min Luo, Junzhe Liu, Chuandong Gong, Shigang Lv, Wei Tu, Minhua Ye, Miaojing Wu, Bing xiao, Hua Fang, Haitao Luo, Xinjun Liu, Xiaoyan Long, Xingen Zhu, Kai Huang, Jingying Li   +16 more
doaj   +3 more sources

The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons

eLife, 2023
Cerebral ischaemia‒reperfusion injury (IRI), during which neurons undergo oxygen-glucose deprivation/reoxygenation (OGD/R), is a notable pathological process in many neurological diseases.
Chi Zhang, Xianfu Yi, Mengfan Hou, Qingyang Li, Xueying Li, Lu Lu, Enlin Qi, Mingxin Wu, Lin Qi, Huan Jian, Zhangyang Qi, Yigang Lv, Xiaohong Kong, Mingjun Bi, Shiqing Feng, Hengxing Zhou   +15 more
doaj   +1 more source

Comprehensive Analysis of the Function, Immune Profiles, and Clinical Implication of m1A Regulators in Lung Adenocarcinoma

Frontiers in Oncology, 2022
BackgroundPrevious studies have demonstrated that transcriptional RNA methyladenosine modification significantly affects tumor initiation and progression.
Guangyao Bao, Tian Li, Xiaojiao Guan, Yao Yao, Jie Liang, Yifang Xiang, Xinwen Zhong   +6 more
doaj   +1 more source