Results 21 to 30 of about 14,453 (241)

m1A regulator-mediated methylation modification patterns correlated with autophagy to predict the prognosis of hepatocellular carcinoma

BMC Cancer
Background N1-methyladenosine (m1A), among the most common internal modifications on RNAs, has a crucial role to play in cancer development. The purpose of this study were systematically investigate the modification characteristics of m1A in ...
Yingmin Wu, Lian Li, Long Wang, Shenjie Zhang, Zhirui zeng, Jieyu Lu, Zhi Wang, Yewei Zhang, Shilong Zhang, Haiyang Li, Tengxiang Chen   +10 more
doaj   +2 more sources

RNA m1A Methyltransferase TRMT6 Predicts Poorer Prognosis and Promotes Malignant Behavior in Glioma

Frontiers in Molecular Biosciences, 2021
Background: Glioma is the most prevalent central nervous system tumor in humans, and its prognosis remains unsatisfactory due to a lack of effective therapeutic targets.
Beibei Wang, Zhao Zhihua
exaly   +3 more sources

THGC_MDA: a method for predicting the associations between m1A modification and diseases based on ternary heterogeneous network and graph convolutional neural network [PDF]

Frontiers in Genetics
m1A modification, as a pivotal RNA epigenetic modification, plays a central regulatory role in the pathogenesis and progression of complex human diseases, including cancer.
Hongyan Gao, Xue Zhou, Lei Bai, Haifeng Yang, Fei Liu   +4 more
doaj   +2 more sources

m1A Regulatory gene signatures are associated with certain immune cell compositions of the tumor microenvironment and predict survival in kidney renal clear cell carcinoma [PDF]

European Journal of Medical Research, 2023
Adenosine N1 methylation (m1A) of RNA, a type of post-transcriptional modification, has been shown to play a significant role in the progression of cancer.
Linjun Zhou, Weidong Zhou, Yuan Li, Ruifang Hua   +3 more
doaj   +2 more sources

Dinoflagellate mRNA is pervasively modified with m1A [PDF]

EMBO Reports
N(1)-methyladenosine (m(1)A) is a very rare RNA modification in mammalian mRNA, which occurs in sequences resembling the T-loop of tRNAs and may not have significant effects on gene expression. A new study in this issue now reports that m(1)A is abundant and dynamic in the 3′UTR of mRNAs of dinoflagellates, and could have an important role in post ...
Jianheng Fox Liu, Samie R Jaffrey
openaire   +3 more sources

Different prognosis of patients with esophageal carcinoma with M1a and regional node involvement [PDF]

Digestive and Liver Disease, 2019
Based on the 6th edition of the American Joint Commission on Cancer (AJCC) staging system for esophageal squamous cell carcinoma (ESCC), M1a node involvement was classified as regional node involvement in the revised 7th/8th edition. However, the clinical significance of M1a node involvement is unclear.
Tae Ryong, Chung, Jie-Hyun, Kim, Ik Jae, Lee, Yeona, Cho, Jun Won, Kim, Chang Geol, Lee, Da Hyun, Jung, Jae Jun, Park, Young Hoon, Youn, Hyojin, Park   +9 more
openaire   +4 more sources

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein [PDF]

Advanced Science
Mitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and ...
Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li   +13 more
doaj   +2 more sources

RNA methylation-related genes of m6A, m5C, and m1A predict prognosis and immunotherapy response in cervical cancer [PDF]

Annals medicus, 2023
Purpose To investigate the prognostic value of N6-methyladenosine (m6A)-, 5-methylcytosine (m5C)-, and N1-methyladenosine (m1A)-related genes in cervical cancer (CESC) and predicting immunotherapy response.
Yan Wang, Yiwen Mao, Caizhi Wang, Xuefeng Jiang, Qionglan Tang, Lingling Wang, Jinguo Zhu, Mengqiu Zhao   +7 more
semanticscholar   +2 more sources

m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma [PDF]

BMC Gastroenterology, 2022
Background The dysregulation of RNA methylation has been demonstrated to contribute to tumorigenicity and progression in recent years. However, the alteration of N1-methyladenosine (m1A) methylation and its role in hepatocellular carcinoma (HCC) remain ...
Chengcheng Tong, Wei Wang, Chiyi He
doaj   +3 more sources

Advances in the Structural and Functional Understanding of m1A RNA Modification

Accounts of Chemical Research
Conspectus RNA modification is a co- or post-transcriptional process by which specific nucleotides are chemically altered by enzymes after their initial incorporation into the RNA chain, expanding the chemical and functional diversity of RNAs.
Jakub Smoczynski, Marcel-Joseph Yared, Vincent Meynier, P. Barraud, C. Tisné   +4 more
semanticscholar   +3 more sources