Results 1 to 10 of about 4,686 (145)

Landscape of N1‐methyladenosin (m1A) modification pattern in colorectal cancer [PDF]

Cancer Reports, 2023
Background N1‐methyladenosine (m1A) is a recently identified mRNA modification. However, it is still unclear that how m1A alteration affects the development of colorectal cancer (CRC).
Chunhui Jiang, Yuan Tian, Chunjie Xu, Hao Zhang, Lei Gu   +4 more
doaj   +5 more sources

Harnessing m1A modification: a new frontier in cancer immunotherapy [PDF]

Frontiers in Immunology
N1-methyladenosine (m1A) modification is an epigenetic change that occurs on RNA molecules, regulated by a suite of enzymes including methyltransferases (writers), demethylases (erasers), and m1A-recognizing proteins (readers).
Xinru Wang, Xiaoqing Ma, Siyu Chen, Minyan Fan, Chenying Jin, Yushi Chen, Shaodong Wang, Zhiying Wang, Fei Meng, Chengwan Zhang, Lin Yang   +10 more
doaj   +4 more sources

The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons [PDF]

eLife, 2023
Cerebral ischaemia‒reperfusion injury (IRI), during which neurons undergo oxygen-glucose deprivation/reoxygenation (OGD/R), is a notable pathological process in many neurological diseases.
Chi Zhang, Xianfu Yi, Mengfan Hou, Qingyang Li, Xueying Li, Lu Lu, Enlin Qi, Mingxin Wu, Lin Qi, Huan Jian, Zhangyang Qi, Yigang Lv, Xiaohong Kong, Mingjun Bi, Shiqing Feng, Hengxing Zhou   +15 more
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Association of genetic variants in m1A modification core genes and neuroblastoma risk [PDF]

BMC Cancer
Neuroblastoma tightly linked with genetic abnormality. The core genes responsible for RNA N1-methyladenosine (m1A) modification are critical in tumor development. Nevertheless, few reports revealed the function of m1A modification core gene polymorphisms
Susu Jiang, Siqi Dong, Yong Li, Lei Lin, Liping Chen, Wenli Zhang, Jinhong Zhu, Xinxin Zhang, Zhonghua Yang, Jiao Zhang, Jiwen Cheng, Li Li, Haixia Zhou, Suhong Li, Wenhan Yang, Jing He, Zhenjian Zhuo   +16 more
doaj   +5 more sources

The landscape of N1-methyladenosine (m1A) modification in mRNA of the decidua in severe preeclampsia [PDF]

Biomolecules & Biomedicine
Recent discoveries in mRNA modification have highlighted N1-methyladenosine (m1A), but its role in preeclampsia (PE) pathogenesis remains unclear. In this study, we utilized methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing ...
Jing Tong, Hua Li, Liang Zhang, Cong Zhang   +3 more
doaj   +4 more sources

Abundant mRNA m1A modification in dinoflagellates: a new layer of gene regulation [PDF]

EMBO Reports
Dinoflagellates, a class of unicellular eukaryotic phytoplankton, exhibit minimal transcriptional regulation, representing a unique model for exploring gene expression.
Chongping Li, Ying Li, Jia Guo, Yuci Wang, Xiaoyan Shi, Yangyi Zhang, Nan Liang, Honghui Ma, Jie Yuan, Jiawei Xu, Hao Chen   +10 more
doaj   +4 more sources

A Novel m1A-Score Model Correlated With the Immune Microenvironment Predicts Prognosis in Hepatocellular Carcinoma

Frontiers in Immunology, 2022
RNA methylation plays crucial roles in gene expression and has been indicated to be involved in tumorigenesis, while it is still unclear whether m1A modifications have potential roles in the prognosis of hepatocellular carcinoma (HCC).
Mingxing Zhao, Shen Shen, Shen Shen, Chen Xue, Chen Xue   +4 more
doaj   +3 more sources

Integrated analyses of m1A regulator-mediated modification patterns in tumor microenvironment-infiltrating immune cells in colon cancer

OncoImmunology, 2021
Emerging evidence has revealed the crucial role of transcriptional RNA methyladenosine modification in immune response. However, the potential role of RNA N1-methyladenosine (m1A) modification of immune cells in the tumor microenvironment (TME) still ...
Yuzhen Gao, Hao Wang, Huiming Li, Xinxin Ye, Yan Xia, Shijin Yuan, Jie Lu, Xinyou Xie, Liangjing Wang, Jun Zhang   +9 more
doaj   +2 more sources

THGC_MDA: a method for predicting the associations between m1A modification and diseases based on ternary heterogeneous network and graph convolutional neural network [PDF]

Frontiers in Genetics
m1A modification, as a pivotal RNA epigenetic modification, plays a central regulatory role in the pathogenesis and progression of complex human diseases, including cancer.
Hongyan Gao, Xue Zhou, Lei Bai, Haifeng Yang, Fei Liu   +4 more
doaj   +2 more sources

ALKBH1‐mediated m1A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression

Molecular Oncology, 2023
Colorectal cancer (CRC) is one of the most common malignancies, and the main cause of death from CRC is tumor metastasis. m1A RNA modification plays critical role in many biological processes. However, the role of m1A modification in CRC remains unclear.
Wenwen Chen, Hao Wang, Shuyi Mi, Liming Shao, Zhipeng Xu, Meng Xue   +5 more
doaj   +2 more sources