Results 1 to 10 of about 1,872,691 (138)

Landscape of N1‐methyladenosin (m1A) modification pattern in colorectal cancer

Cancer Reports, 2023
Background N1‐methyladenosine (m1A) is a recently identified mRNA modification. However, it is still unclear that how m1A alteration affects the development of colorectal cancer (CRC).
Chunhui Jiang, Yuan Tian, Chunjie Xu, Hao Zhang, Lei Gu   +4 more
doaj   +5 more sources

The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons

eLife, 2023
Cerebral ischaemia‒reperfusion injury (IRI), during which neurons undergo oxygen-glucose deprivation/reoxygenation (OGD/R), is a notable pathological process in many neurological diseases.
Chi Zhang, Xianfu Yi, Mengfan Hou, Qingyang Li, Xueying Li, Lu Lu, Enlin Qi, Mingxin Wu, Lin Qi, Huan Jian, Zhangyang Qi, Yigang Lv, Xiaohong Kong, Mingjun Bi, Shiqing Feng, Hengxing Zhou   +15 more
doaj   +4 more sources

Harnessing m1A modification: a new frontier in cancer immunotherapy

Frontiers in Immunology
N1-methyladenosine (m1A) modification is an epigenetic change that occurs on RNA molecules, regulated by a suite of enzymes including methyltransferases (writers), demethylases (erasers), and m1A-recognizing proteins (readers).
Xinru Wang, Xiaoqing Ma, Siyu Chen, Minyan Fan, Chenying Jin, Yushi Chen, Shaodong Wang, Zhiying Wang, Fei Meng, Chengwan Zhang, Lin Yang   +10 more
doaj   +4 more sources

m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma [PDF]

BMC Gastroenterology, 2022
Background The dysregulation of RNA methylation has been demonstrated to contribute to tumorigenicity and progression in recent years. However, the alteration of N1-methyladenosine (m1A) methylation and its role in hepatocellular carcinoma (HCC) remain ...
Chengcheng Tong, Wei Wang, Chiyi He
doaj   +4 more sources

Abundant mRNA m1A modification in dinoflagellates: a new layer of gene regulation

EMBO Reports
Dinoflagellates, a class of unicellular eukaryotic phytoplankton, exhibit minimal transcriptional regulation, representing a unique model for exploring gene expression.
Chongping Li, Ying Li, Jia Guo, Yuci Wang, Xiaoyan Shi, Yangyi Zhang, Nan Liang, Honghui Ma, Jie Yuan, Jiawei Xu, Hao Chen   +10 more
doaj   +4 more sources

Integrated analyses of m1A regulator-mediated modification patterns in tumor microenvironment-infiltrating immune cells in colon cancer

OncoImmunology, 2021
Emerging evidence has revealed the crucial role of transcriptional RNA methyladenosine modification in immune response. However, the potential role of RNA N1-methyladenosine (m1A) modification of immune cells in the tumor microenvironment (TME) still ...
Yuzhen Gao, Hao Wang, Huiming Li, Xinxin Ye, Yan Xia, Shijin Yuan, Jie Lu, Xinyou Xie, Liangjing Wang, Jun Zhang   +9 more
doaj   +3 more sources

Association of m1A modification gene polymorphisms with glioma risk in Chinese children

MedComm – Oncology, 2023
Glioma is a highly heterogeneous malignancy with a high mortality rate and poor prognosis. m1A methylation modifications are associated with gliomagenesis.
Fan Liao, Rui‐Xi Hua, Xingyu Jia, Yuxiang Liao, Li Yuan, Jichen Ruan, Tianfeng Li, Zhenjian Zhuo, Jing He   +8 more
doaj   +3 more sources

The landscape of N1-methyladenosine (m1A) modification in mRNA of the decidua in severe preeclampsia

Biomolecules & Biomedicine
Recent discoveries in mRNA modification have highlighted N1-methyladenosine (m1A), but its role in preeclampsia (PE) pathogenesis remains unclear. In this study, we utilized methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing ...
Jing Tong, Hua Li, Liang Zhang, Cong Zhang   +3 more
doaj   +4 more sources

m1A regulator-mediated methylation modification patterns correlated with autophagy to predict the prognosis of hepatocellular carcinoma

BMC Cancer
Background N1-methyladenosine (m1A), among the most common internal modifications on RNAs, has a crucial role to play in cancer development. The purpose of this study were systematically investigate the modification characteristics of m1A in ...
Yingmin Wu, Lian Li, Long Wang, Shenjie Zhang, Zhirui zeng, Jieyu Lu, Zhi Wang, Yewei Zhang, Shilong Zhang, Haiyang Li, Tengxiang Chen   +10 more
doaj   +3 more sources

TRMT6/TRMT61A-mediated tRNA m1A modification enhances protein translation and activates the IRE1α–XBP1s pathway to promote anaplastic thyroid cancer progression

Cellular & Molecular Biology Letters
Background Anaplastic thyroid cancer (ATC) is a highly aggressive malignancy with rapid progression and poor prognosis. Although N1-methyladenosine (m1A) modification has been implicated in cancer development, the specific role of tRNA m1A modification ...
Ying Ding, Ziyang Feng, Guanjun Chen, Yunqing Liu, Yuxing Zhu, Ke Cao   +5 more
doaj   +3 more sources