Results 31 to 40 of about 4,686 (145)

N1-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction

Cell Death Discovery, 2023
N1-Methyladenosine (m1A) is an abundant modification of transcripts, plays important roles in regulating mRNA structure and translation efficiency, and is dynamically regulated under stress.
Zhangyang Qi, Chi Zhang, Huan Jian, Mengfan Hou, Yongfu Lou, Yi Kang, Wei Wang, Yigang Lv, Shenghui Shang, Chaoyu Wang, Xueying Li, Shiqing Feng, Hengxing Zhou   +12 more
doaj   +1 more source

Comprehensive Analysis of the Function, Immune Profiles, and Clinical Implication of m1A Regulators in Lung Adenocarcinoma

Frontiers in Oncology, 2022
BackgroundPrevious studies have demonstrated that transcriptional RNA methyladenosine modification significantly affects tumor initiation and progression.
Guangyao Bao, Tian Li, Xiaojiao Guan, Yao Yao, Jie Liang, Yifang Xiang, Xinwen Zhong   +6 more
doaj   +1 more source

m1A and m6A modifications function cooperatively to facilitate rapid mRNA degradation

Cell Reports, 2022
N6-Methyladenosine (m6A), the most abundant internal mRNA modification, affects multiple steps in gene expression. Mechanistically, the binding of YTHDF2 to m6A on mRNAs elicits rapid mRNA degradation by recruiting several RNA degrading enzymes. Here, we show that N1-methyladenosine (m1A), another type of RNA modification, accelerates rapid m6A RNA ...
Sung Ho Boo, Hongseok Ha, Yoon Ki Kim
openaire   +2 more sources

A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase [PDF]

Nucleic Acids Research, 2004
The modified nucleoside 1-methyladenosine (m(1)A) is found in the T-loop of many tRNAs from organisms belonging to the three domains of life (Eukaryota, Bacteria, Archaea). In the T-loop of eukaryotic and bacterial tRNAs, m(1)A is present at position 58, whereas in archaeal tRNAs it is present at position(s) 58 and/or 57, m(1)A57 being the obligatory ...
Roovers, Martine, Wouters, Johan, Bujnicki, Janusz Marek, Tricot, Catherine, Stalon, Victor, Grosjean, Henri, Droogmans, Louis   +6 more
openaire   +4 more sources

Gene Expression Profile of RNA N1-methyladenosine methyltransferases [PDF]

E3S Web of Conferences, 2020
N1-methyladenosine (m1A) is a kind of common and abundant methylation modification in eukaryotic mRNA and long-chain non-coding RNA. Nucleoside methyltransferase (MTase) of m1A is a diverse protein family, which is characterized by the presence of ...
Rao Mingzhu
doaj   +1 more source

tRNA m1A modification regulates cholesterol biosynthesis to promote antitumor immunity of CD8+ T cells. [PDF]

J Exp Med
Activation of CD8+ T cells necessitates rapid metabolic reprogramming to fulfill the substantial biosynthetic demands of effector functions. However, the posttranscriptional mechanisms underpinning this process remain obscure. The transfer RNA (tRNA) N1-methyladenine (m1A) modification, essential for tRNA stability and protein translation, has an ...
Miao S, Li H, Song X, Liu Y, Wang G, Kan C, Ye Y, Liu RJ, Li HB.   +8 more
europepmc   +3 more sources

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment. [PDF]

MedComm (2020)
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Li Q, Sun Y, Lin S, Yuan Q.
europepmc   +2 more sources

m1A Regulatory gene signatures are associated with certain immune cell compositions of the tumor microenvironment and predict survival in kidney renal clear cell carcinoma

European Journal of Medical Research, 2023
Adenosine N1 methylation (m1A) of RNA, a type of post-transcriptional modification, has been shown to play a significant role in the progression of cancer.
Linjun Zhou, Weidong Zhou, Yuan Li, Ruifang Hua   +3 more
doaj   +1 more source

De-succinylation-induced accumulation of TRMT10C in the nucleus plays a detrimental role in coronary microembolization via its m1A modification function. [PDF]

Int J Biol Sci
Coronary microembolization (CME) refers to embolism in the coronary microcirculation. This study showed a reduction in succinyl transferase (CPT1A) and the succinylation substrate (succinyl-CoA) in cardiomyocytes in CME models, suppressing the succinylation of the mitochondrially localized protein TRMT10C.
Hu CK, Huang WZ, He L, Chang C, Ren YL, Dai RX, Wu Q, Su Q.   +7 more
europepmc   +3 more sources

tRNA m¹A modification is essential for gut homeostasis and function of group 3 innate lymphoid cells. [PDF]

Cell Discov
Abstract Group 3 innate lymphoid cells (ILC3s) play crucial roles in maintaining intestinal homeostasis and defending against bacterial infections. However, the epigenetic mechanisms that regulate ILC3 responses are not well understood.
Li J, Tang Z, Chen Y, Cai X, Wu L, Wang G, Kan C, Li B, Su B, Li H, Chu C, Li HB.   +11 more
europepmc   +3 more sources