Results 1 to 10 of about 2,197 (160)

Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs [PDF]

Nucleic Acids Research, 2018
Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m1A) and 3-methylcytidine (m3C) demethylase of tRNA.
Zhuojia Chen, Meijie Qi, Bin Shen, Guanzheng Luo, Yingmin Wu, Jiexin Li, Zhike Lu, Zhong Zheng, Qing Dai, Hongsheng Wang   +9 more
semanticscholar   +3 more sources

Genome-Wide Association Study for Carcass Traits in an Experimental Nelore Cattle Population. [PDF]

PLoS ONE, 2017
The purpose of this study was to identify genomic regions associated with carcass traits in an experimental Nelore cattle population. The studied data set contained 2,306 ultrasound records for longissimus muscle area (LMA), 1,832 for backfat thickness ...
Rafael Medeiros de Oliveira Silva, Nedenia Bonvino Stafuzza, Breno de Oliveira Fragomeni, Gregório Miguel Ferreira de Camargo, Thaís Matos Ceacero, Joslaine Noely Dos Santos Gonçalves Cyrillo, Fernando Baldi, Arione Augusti Boligon, Maria Eugênia Zerlotti Mercadante, Daniela Lino Lourenco, Ignacy Misztal, Lucia Galvão de Albuquerque   +11 more
doaj   +1 more source

TRAT1 overexpression delays cancer progression and is associated with immune infiltration in lung adenocarcinoma

Frontiers in Oncology, 2022
The roles and mechanisms of T-cell receptor (TCR)-associated transmembrane adaptor 1 (TRAT1) in lung adenocarcinoma (LAC) have not yet been reported in the relevant literature.
Xiao-Yue Xiao, Qiang Guo, Song Tong, Chuang-Yan Wu, Jiu-Ling Chen, Yu Ding, Jun-Hao Wan, Shan-Shan Chen, Si-Hua Wang   +8 more
doaj   +1 more source

Towards a 'druggable' epitranscriptome: Compounds that target RNA modifications in cancer [PDF]

, 2021
Epitranscriptomics is an exciting emerging area that studies biochemical modifications of RNA. The field is boosted by the technical efforts of the last decade to characterize and quantify RNA modifications which have led to a map of post-transcripcional
Berdasco, María, Esteller, Manel
core   +2 more sources

N1-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction

Cell Death Discovery, 2023
N1-Methyladenosine (m1A) is an abundant modification of transcripts, plays important roles in regulating mRNA structure and translation efficiency, and is dynamically regulated under stress.
Zhangyang Qi, Chi Zhang, Huan Jian, Mengfan Hou, Yongfu Lou, Yi Kang, Wei Wang, Yigang Lv, Shenghui Shang, Chaoyu Wang, Xueying Li, Shiqing Feng, Hengxing Zhou   +12 more
doaj   +1 more source

Inhibition of AlkB Nucleic Acid Demethylases: Promising New Epigenetic Targets [PDF]

, 2021
The AlkB family of nucleic acid demethylases is currently of intense chemical, biological, and medical interest because of its critical roles in several key cellular processes, including epigenetic gene regulation, RNA metabolism, and DNA repair ...
Das, M, Perry, GS, Woon, ECY
core  

A novel tRNA-derived fragment tRF-3022b modulates cell apoptosis and M2 macrophage polarization via binding to cytokines in colorectal cancer

Journal of Hematology & Oncology, 2022
tRNA-derived fragments (tRFs) are a class of small RNAs that occur when tRNAs are broken down by enzymes due to stress. Increasing reports have shown that tRFs are associated with multiple physiological and pathological processes, especially in cancers ...
Sicheng Lu, Xiaoman Wei, Lihuiping Tao, Dan Dong, Wenlong Hu, Qinchang Zhang, Yuquan Tao, Chengtao Yu, Dongdong Sun, Haibo Cheng   +9 more
doaj   +1 more source

Small RNAs derived from tRNA fragmentation regulate the functional maturation of neonatal β cells. [PDF]

, 2022
tRNA-derived fragments (tRFs) are an emerging class of small non-coding RNAs with distinct cellular functions. Here, we studied the contribution of tRFs to the regulation of postnatal β cell maturation, a critical process that may lead to diabetes ...
Bayazit, M.B., Brozzi, F., Cosentino, C., Guay, C., Jacovetti, C., Regazzi, R., Rodriguez-Trejo, A., Sobel, J., Stoll, L., Wu, K.   +9 more
core   +1 more source

Progress of research on m6A demethylases in gastric cancer

Shanghai Jiaotong Daxue xuebao. Yixue ban
Gastric cancer (GC) is one of the most common malignancies in the digestive system. Many patients are found in advanced stage and have a poor prognosis. Surgery and chemotherapy remain the main treatments for gastric cancer. N6-methyladenosine (m6A) is a
JIANG Shuang, YU Jiwei
doaj   +1 more source

Expression of ALKBH3 and its effects on proliferation, migration, and invasion of lung adenocarcinoma A549 cells: bioinformatics analysis and in vitro and in vivo experiments

Journal of Cancer Metastasis and Treatment
Objective: To use bioinformatics analysis and in vitro and in vivo experiments to study the biological role of ALKBH3 in lung adenocarcinoma. Methods: Bioinformatics analysis of ALKBH3 was performed using databases.
Song Zhang, Haoyu Chen, Tao Liu, Chao Qin, Hang Yan, Haiyang Hu, Shengjie Tang, Tingting Dai, Danyu Ji, Li Yang, Haining Zhou   +10 more
semanticscholar   +1 more source