Results 1 to 10 of about 1,458 (131)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology [PDF]

Advanced Science
Amyloid‐beta (Aβ) aggregation, mitochondrial dysfunction, and cognitive decline are hallmarks of Alzheimer's disease (AD), but its initiating molecular events remain unknown.
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
doaj   +4 more sources

PUS7‐dependent pseudouridylation of ALKBH3 mRNA inhibits gastric cancer progression [PDF]

Clinical and Translational Medicine
Background RNA pseudouridylation is a critical post‐transcriptional modification that influences gene expression and impacts various biological functions.
Yongxia Chang
exaly   +5 more sources

ALKBH3-regulated m1A of ALDOA potentiates glycolysis and doxorubicin resistance of triple negative breast cancer cells [PDF]

Acta Pharmaceutica Sinica B
Chemotherapy is currently the mainstay of systemic management for triple-negative breast cancer (TNBC), but chemoresistance significantly impacts patient outcomes.
Yuhua Deng, Peixian Chen, Hong-Sheng Wang   +2 more
exaly   +6 more sources

ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation [PDF]

Clinical and Translational Medicine
Background Myocardial ischemia/reperfusion (I/R) injury induces an intense inflammatory response and involves multiple cell death pathways. PANoptosis, an integrated cell death process involving pyroptosis, apoptosis and necroptosis, is a major driver of
Hongtao Diao, Chunlei Wang, Yuting Xiong, Qiaoyue Zhao, Xinyue Zhang, Xiaohui Qi, Yuan Zou, Jiaxuan Li, Linghua Zeng, Wei Si, Feng Zhang, Ping Pang, Ning Wang, Yu Bian, Baofeng Yang   +14 more
doaj   +3 more sources

ALKBH3-dependent m1A demethylation of Aurora A mRNA inhibits ciliogenesis

Cell Discovery, 2022
Primary cilia are antenna-like subcellular structures to act as signaling platforms to regulate many cellular processes and embryonic development. m1A RNA modification plays key roles in RNA metabolism and gene expression; however, the physiological ...
Jianzhao Liu, Xiaoyi Yan, Qiang Shu
exaly   +4 more sources

Dataset for Spectroscopic, Structural and Dynamic Analysis of Human Fe(II)/2OG-Dependent Dioxygenase ALKBH3

Data, 2023
Fe(II)/2OG-dependent dioxygenases of the AlkB family catalyze a direct removal of alkylated damages in the course of DNA and RNA repair. A human homolog of the E. coli AlkB ALKBH3 protein is able to hydroxylate N1-methyladenine, N3-methylcytosine, and N1-
Lyubov Yu Kanazhevskaya, Polina V Zhdanova, Vladimir V Koval   +2 more
exaly   +4 more sources

5′tRF‐GlyGCC Promotes Breast Cancer Progression via LDHA‐Mediated Glycolysis and Macrophage Polarization [PDF]

Advanced Science
Breast cancer (BC) progression is intricately linked to the dysregulation of transfer RNA‐derived fragments (tRFs). Through comprehensive analysis of The Cancer Genome Atlas (TCGA) data, it is demonstrated that 5′tRF‐GlyGCC is overexpressed in BC tissues
Cheng Yi, Yunqing Lu, Xing Chang, Ying Wang, Jiawang Zhou, Guoyou Xie, Lijun Tao, Zhaotong Wang, Yifan Tian, Lihong Wang, Feng Tang, Yijing Zheng, Xinchen Yue, Jinping Lei, Xiansong Wang, Lichen Ge, Zhuojia Chen, Hongsheng Wang   +17 more
doaj   +3 more sources

TRMT10C promotes mitochondrial fission through transferrin receptor m1A methylation modification and aggravates the progression of atrial fibrillation. [PDF]

J Cell Commun Signal
TRMT10C promotes mitochondrial dynamics imbalance (excessive fission) by regulating TFRC m1A methylation modification, induces myocardial fibrosis, and exacerbates the progression of AF. Abstract Atrial fibrillation (AF) is a common cardiac arrhythmia often accompanied by structural remodeling of the atria, particularly fibrosis, and disruption of ...
Li N, Zhang H.
europepmc   +2 more sources

Histone modification-regulated LncRNA DLEU1 interacts with ASCC2/ALKBH3 complex to drive DNA repair, antioxidant homeostasis and glucose metabolism in gastric cancer [PDF]

Biomarker Research
Background Long non-coding RNA (lncRNA) DLEU1 has been implicated in tumorigenesis, yet its mechanistic role in gastric cancer (GC) remains elusive. Methods We investigated the epigenetic regulation and oncogenic function of DLEU1 in GC through chromatin
Xiaoyan Zhang, Xin Wang, Qi Wang, Xu Wang, Hui Sun, Yingxue Liu, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Jie Chen, Xiaoyu Wang, Lu Gan, Mierxiati Abudurexiti, Wenfeng Wang, Jinjia Chang, Weiqi Sheng, Midie Xu   +19 more
doaj   +2 more sources

Interplay of RNA m⁶A/m¹A/m⁵C/m⁷G/ψ Regulators Predicting the Prognosis of Pancreatic Cancer. [PDF]

FASEB Bioadv
In this study, we comprehensively analyze the 64 RNA modification regulators, including 24 m6A regulators, 13 m1A regulators, 12 m5C regulators, 9 m7G regulators, and 12 pseudouridine regulators in pancreatic cancer in TCGA, GTEx, and HPA databases. We investigate their RNA and protein expression, their association with patients' clinical significance,
Chen S, Mao J, Xu L, Lu L, Hao Y.
europepmc   +2 more sources