Results 21 to 30 of about 2,197 (160)

Feedback regulation between histone lactylation and ALKBH3-mediated glycolysis regulates age-related macular degeneration pathology [PDF]

Proceedings of the National Academy of Sciences of the United States of America
Significance Age-related macular degeneration (AMD) is a leading cause of blindness in older adults, highlighting the urgent need for effective treatments.
Biao Yan, Qinghuai Liu, Chen Zhao
exaly   +4 more sources

ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells

Blood Science, 2020
. ALKBH3, a demethylase responsible for demethylating N1-methyladenosine (m1A) in mRNA and N1-methyldeoxyadenosine in single-stranded DNA, plays an important role in DNA repair and cancer cell proliferation.
Hanqing He, Yuqian Wang, Jianwei Wang
doaj   +4 more sources

ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA [PDF]

Journal of Translational Medicine, 2021
Background Reversible enzymatic methylation of mammalian mRNA is widespread and serves crucial regulatory functions, but little is known to what degree chemical alkylators mediate overlapping modifications and whether cells distinguish aberrant from ...
Kristian Lied Wollen, Lars Hagen, Cathrine B. Vågbø, Renana Rabe, Tobias S. Iveland, Per Arne Aas, Animesh Sharma, Bjørnar Sporsheim, Hilde O. Erlandsen, Vuk Palibrk, Magnar Bjørås, Davi M. Fonseca, Nima Mosammaparast, Geir Slupphaug   +13 more
doaj   +5 more sources

ALKBH3 suppresses ischemia/reperfusion‐induced PANoptosis by regulating the ZBED6/STAT1/AIM2 axis through m1A demethylation [PDF]

Clinical and Translational Medicine
Background Myocardial ischemia/reperfusion (I/R) injury induces an intense inflammatory response and involves multiple cell death pathways. PANoptosis, an integrated cell death process involving pyroptosis, apoptosis and necroptosis, is a major driver of
Hongtao Diao, Chunlei Wang, Yuting Xiong, Qiaoyue Zhao, Xinyue Zhang, Xiaohui Qi, Yuan Zou, Jiaxuan Li, Linghua Zeng, Wei Si, Feng Zhang, Ping Pang, Ning Wang, Yu Bian, Baofeng Yang   +14 more
doaj   +3 more sources

Dataset for Spectroscopic, Structural and Dynamic Analysis of Human Fe(II)/2OG-Dependent Dioxygenase ALKBH3

Data, 2023
Fe(II)/2OG-dependent dioxygenases of the AlkB family catalyze a direct removal of alkylated damages in the course of DNA and RNA repair. A human homolog of the E. coli AlkB ALKBH3 protein is able to hydroxylate N1-methyladenine, N3-methylcytosine, and N1-
Lyubov Yu. Kanazhevskaya, Alexey A. Gorbunov, Polina V. Zhdanova, Vladimir V. Koval   +3 more
doaj   +3 more sources

Histone modification-regulated LncRNA DLEU1 interacts with ASCC2/ALKBH3 complex to drive DNA repair, antioxidant homeostasis and glucose metabolism in gastric cancer [PDF]

Biomarker Research
Background Long non-coding RNA (lncRNA) DLEU1 has been implicated in tumorigenesis, yet its mechanistic role in gastric cancer (GC) remains elusive. Methods We investigated the epigenetic regulation and oncogenic function of DLEU1 in GC through chromatin
Xiaoyan Zhang, Xin Wang, Qi Wang, Xu Wang, Hui Sun, Yingxue Liu, Cong Tan, Shujuan Ni, Weiwei Weng, Meng Zhang, Lei Wang, Dan Huang, Jie Chen, Xiaoyu Wang, Lu Gan, Mierxiati Abudurexiti, Wenfeng Wang, Jinjia Chang, Weiqi Sheng, Midie Xu   +19 more
doaj   +3 more sources

CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancer [PDF]

BMC Cancer, 2017
Background DNA repair of alkylation damage is defective in various cancers. This occurs through somatically acquired inactivation of the MGMT gene in various cancer types, including breast cancers. In addition to MGMT, the two E.
Olafur Andri Stefansson, Stefan Hermanowicz, Jasper van der Horst, Holmfridur Hilmarsdottir, Zuzanna Staszczak, Jon Gunnlaugur Jonasson, Laufey Tryggvadottir, Thorkell Gudjonsson, Stefan Sigurdsson   +8 more
doaj   +5 more sources

ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells

Blood Science, 2021
[This corrects the article DOI: 10.1097/BS9.0000000000000057.].
doaj   +3 more sources

ALKBH3-AS1 drives SMAD3 stabilization via YTHDF2: Uncovering a pathogenic pathway for Th17 dysregulation in SLE

Pharmacological Research
Th17 cells and interleukin-17A (IL-17A) drive the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis (LN). Although myeloid-derived suppressor cells (MDSCs) promote the differentiation of Th17 cells, the epigenetic mechanisms remain ...
Yanli Zhang, Yu Zhen, Zhanchuan Ma, Xiaocong Wang, Hui Yu, Cong Hu, Sensen Su, Chang Shu, Guifeng Jia, Han Qin, Yueming He, Siyuan Ma, Huanfa Yi   +12 more
doaj   +3 more sources

Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells [PDF]

Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2019
In ovarian and breast cancers, the actions of the cytokine CSF-1 lead to poor prognosis. CSF-1 expression can be regulated post-transcriptionally. RNA methylation is another layer of posttranscriptional regulation.
Ho-Hyung Woo
exaly   +4 more sources