Results 21 to 30 of about 1,458 (131)

ALKBH3-mediated m1A demethylation promotes the malignant progression of acute myeloid leukemia by regulating ferroptosis through the upregulation of ATF4 expression

Hematology
To investigate the role of ALKBH3 in acute myeloid leukemia (AML), we constructed an animal model of xenotransplantation of AML. Our study demonstrated that ALKBH3-mediated m1A demethylation inhibits ferroptosis in KG-1 cells by increasing ATF4 ...
Xin Liu, Xinghua Pan
exaly   +3 more sources

Mediation Role of Gut Microbiota in the Causal Relationship Between m6A Regulatory Genes and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Mendelian Randomization Study [PDF]

Biomedicines
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a globally prevalent condition with a complex pathogenesis. While both m6A RNA methylation regulators and gut microbiota have been independently implicated in MASLD, their ...
Dongmei Qiu, Liwei Suo, Tao Wei, Zhenwei Lu, Qixin Weng, Jianxing Xiao, Xinchi Wang, Qinyu Xu, Jingtong Wu   +8 more
doaj   +2 more sources

Structural Analysis of the AlkB Family in Poultry [PDF]

Animals
The objective of this study was to identify the AlkB family genes in poultry using bioinformatics, and to explore their molecular characteristics, evolutionary relationships, and expression patterns to clarify their potential functions in poultry.
Yuling Niu, Kan Li, Xuerong You, Yutao Wu, Xue Du, Ayong Zhao, Zhijun Wang   +6 more
doaj   +2 more sources

Deficiency of N1-Adenine Methyltransferase Aggravates RNA and Protein Aggregation [PDF]

Cells
RNA modifications regulate diverse aspects of transcripts’ function and stability. Among these, N1-methyladenine (m1A) is a reversible mark primarily installed by the TRMT6/TRMT61A methyltransferase on tRNA, though it is also found on other RNA types ...
Marion Alriquet, Roberto Arsiè, Giulia Calloni, Gian G. Tartaglia, R. Martin Vabulas   +4 more
doaj   +2 more sources

ALKBH3-AS1 drives SMAD3 stabilization via YTHDF2: Uncovering a pathogenic pathway for Th17 dysregulation in SLE

Pharmacological Research
Th17 cells and interleukin-17A (IL-17A) drive the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis (LN). Although myeloid-derived suppressor cells (MDSCs) promote the differentiation of Th17 cells, the epigenetic mechanisms remain ...
Yanli Zhang, Yu Zhen, Zhanchuan Ma, Xiaocong Wang, Hui Yu, Cong Hu, Sensen Su, Chang Shu, Guifeng Jia, Han Qin, Yueming He, Siyuan Ma, Huanfa Yi   +12 more
doaj   +3 more sources

USP7 promotes temozolomide resistance by stabilizing MGMT in glioblastoma [PDF]

Cell Death and Disease
Glioblastoma (GBM), a World Health Organization (WHO) grade IV glioma, is one of the most lethal brain tumors, with a poor prognosis and limited treatment options.
Jiabing Li, Xiaorong Feng, Zhaohui Liu, Yunfang Deng, Zhiming Sun, Bei Chen, Lihui Wu, Xiaolong Wang, Lin Miao, Liyuan Zeng, Lei Hu, Yuming He, Ying Sheng, Yue Liu, Yu Zhao   +14 more
doaj   +2 more sources

ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells

Blood Science, 2021
doaj   +2 more sources

Genetic variants of m1A modification genes and the risk of neuroblastoma: novel insights from a Chinese case-control study [PDF]

Human Genomics
Background The N1-adenosine methylation (m1A) modification plays a significant role in various cancers. However, the functions of m1A modification genes and their variants in neuroblastoma remain to be elucidated.
Jiaming Chang, Lei Lin, Wenli Zhang, Jiliang Yang, Mengzhen Zhang, Huimin Yin, Xinxin Zhang, Chunlei Zhou, Yan Zou, Jing He   +9 more
doaj   +2 more sources

LncRNA ALKBH3‐AS1 enhances ALKBH3 mRNA stability to promote hepatocellular carcinoma cell proliferation and invasion

Journal of Cellular and Molecular Medicine, 2022
AbstractLong noncoding RNAs (lncRNAs) are confirmed as the key regulators of hepatocellular carcinoma (HCC) occurrence and progression, but the role of AlkB homologue 3 antisense RNA 1 (ALKBH3‐AS1) in HCC is unclear. We revealed the overexpression of ALKBH3‐AS1 in HCC tissues. The upregulated levels of ALKBH3‐AS1 were observed in HCC cells.
Qiliang Lu, Hao Wang, Xiangxiang Lei, Qiancheng Ma, Jie Zhao, Wen Sun, Cheng Guo, Dongsheng Huang, Qiuran Xu   +8 more
openaire   +2 more sources

Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome [PDF]

Blood, 2021
We thank CERCA Programme/Generalitat de Catalunya for institutional support. This work was supported by the Health Department PERIS-project no. SLT/002/16/00374 and AGAUR-projects no. 2017SGR1080 of the Catalan Government (Generalitat de Catalunya); Ministerio de Ciencia e Innovación (MCI), Agencia Estatal de Investigación (AEI) and European Regional ...
Rosaura Esteve-Puig, Fina Climent, David Piñeyro, Eva Domingo-Domènech, Veronica Davalos, Maite Encuentra, Anna Rea, Nadia Espejo-Herrera, Marta Soler, Miguel Lopez, Vanessa Ortiz-Barahona, Gustavo Tapia, José-Tomás Navarro, Joan Cid, Lourdes Farré, Alberto Villanueva, Isolda Casanova, Ramon Mangues, Pablo Santamarina-Ojeda, Agustín F. Fernández, Mario F. Fraga, Miguel Angel Piris, Nitzan Kol, Chen Avrahami, Sharon Moshitch-Moshkovitz, Gideon Rechavi, Anna Sureda, Manel Esteller   +27 more
openaire   +4 more sources