Results 41 to 50 of about 1,458 (131)

Transfer RNA demethylase ALKBH3 promotes cancer progression via induction of tRNA-derived small RNAs [PDF]

Nucleic Acids Research, 2018
Transfer RNA is heavily modified and plays a central role in protein synthesis and cellular functions. Here we demonstrate that ALKBH3 is a 1-methyladenosine (m1A) and 3-methylcytidine (m3C) demethylase of tRNA. ALKBH3 can promote cancer cell proliferation, migration and invasion.
Zhuojia Chen, Meijie Qi, Bin Shen, Guanzheng Luo, Yingmin Wu, Jiexin Li, Zhike Lu, Zhong Zheng, Qing Dai, Hongsheng Wang   +9 more
openaire   +2 more sources

5′-tRF-GlyGCC: a tRNA-derived small RNA as a novel biomarker for colorectal cancer diagnosis

Genome Medicine, 2021
Background tRNA-derived small RNAs (tDRs), which are widely distributed in human tissues including blood and urine, play an important role in the progression of cancer. However, the expression of tDRs in colorectal cancer (CRC) plasma and their potential
Yingmin Wu, Xiangling Yang, Guanmin Jiang, Haisheng Zhang, Lichen Ge, Feng Chen, Jiexin Li, Huanliang Liu, Hongsheng Wang   +8 more
doaj   +1 more source

m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in Gastrointestinal Cancer

Translational Oncology, 2019
BACKGROUND: Gene expression can be posttranscriptionally regulated by a complex network of proteins. N1-methyladenosine (m1A) is a newly validated RNA modification.
Yueshui Zhao, Qijie Zhao, Parham Jabbarzadeh Kaboli, Jing Shen, Mingxing Li, Xu Wu, Jianhua Yin, Hanyu Zhang, Yuanlin Wu, Ling Lin, Lingling Zhang, Lin Wan, Qinglian Wen, Xiang Li, Chi Hin Cho, Tao Yi, Jing Li, Zhangang Xiao   +17 more
doaj   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

Genome-Wide Association Study for Carcass Traits in an Experimental Nelore Cattle Population. [PDF]

PLoS ONE, 2017
The purpose of this study was to identify genomic regions associated with carcass traits in an experimental Nelore cattle population. The studied data set contained 2,306 ultrasound records for longissimus muscle area (LMA), 1,832 for backfat thickness ...
Rafael Medeiros de Oliveira Silva, Nedenia Bonvino Stafuzza, Breno de Oliveira Fragomeni, Gregório Miguel Ferreira de Camargo, Thaís Matos Ceacero, Joslaine Noely Dos Santos Gonçalves Cyrillo, Fernando Baldi, Arione Augusti Boligon, Maria Eugênia Zerlotti Mercadante, Daniela Lino Lourenco, Ignacy Misztal, Lucia Galvão de Albuquerque   +11 more
doaj   +1 more source

TRAT1 overexpression delays cancer progression and is associated with immune infiltration in lung adenocarcinoma

Frontiers in Oncology, 2022
The roles and mechanisms of T-cell receptor (TCR)-associated transmembrane adaptor 1 (TRAT1) in lung adenocarcinoma (LAC) have not yet been reported in the relevant literature.
Xiao-Yue Xiao, Qiang Guo, Song Tong, Chuang-Yan Wu, Jiu-Ling Chen, Yu Ding, Jun-Hao Wan, Shan-Shan Chen, Si-Hua Wang   +8 more
doaj   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology (Adv. Sci. 32/2026)

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Alzheimer's Disease The cover illustrates how ALKBH3 demethylates PINK1 mRNA at m1A sites, destabilizing PINK1 transcripts and suppressing mitophagy, which drives Alzheimer's pathology (winter scene). Restoring ALKBH3 function rescues mitophagy (spring scene), with PINK1 (pink flower) facilitating mitochondrial transport along neurites (branches). More
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

N1-Methyladenosine modification of mRNA regulates neuronal gene expression and oxygen glucose deprivation/reoxygenation induction

Cell Death Discovery, 2023
N1-Methyladenosine (m1A) is an abundant modification of transcripts, plays important roles in regulating mRNA structure and translation efficiency, and is dynamically regulated under stress.
Zhangyang Qi, Chi Zhang, Huan Jian, Mengfan Hou, Yongfu Lou, Yi Kang, Wei Wang, Yigang Lv, Shenghui Shang, Chaoyu Wang, Xueying Li, Shiqing Feng, Hengxing Zhou   +12 more
doaj   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, Volume 4, Issue 2, Page 91-107, June 2026.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source