Results 41 to 50 of about 2,197 (160)

Mediation Role of Gut Microbiota in the Causal Relationship Between m6A Regulatory Genes and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Mendelian Randomization Study [PDF]

Biomedicines
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a globally prevalent condition with a complex pathogenesis. While both m6A RNA methylation regulators and gut microbiota have been independently implicated in MASLD, their ...
Dongmei Qiu, Liwei Suo, Tao Wei, Zhenwei Lu, Qixin Weng, Jianxing Xiao, Xinchi Wang, Qinyu Xu, Jingtong Wu   +8 more
doaj   +2 more sources

Contrasting role of ASCC3 and ALKBH3 in determining genomic alterations in Glioblastoma Multiforme

Journal of Emerging Investigators, 2022
Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS).
A. Sriram, Jeru-Manoj Manuel
semanticscholar   +2 more sources

5′tRF‐GlyGCC Promotes Breast Cancer Progression via LDHA‐Mediated Glycolysis and Macrophage Polarization [PDF]

Advanced Science
Breast cancer (BC) progression is intricately linked to the dysregulation of transfer RNA‐derived fragments (tRFs). Through comprehensive analysis of The Cancer Genome Atlas (TCGA) data, it is demonstrated that 5′tRF‐GlyGCC is overexpressed in BC tissues
Cheng Yi, Yunqing Lu, Xing Chang, Ying Wang, Jiawang Zhou, Guoyou Xie, Lijun Tao, Zhaotong Wang, Yifan Tian, Lihong Wang, Feng Tang, Yijing Zheng, Xinchen Yue, Jinping Lei, Xiansong Wang, Lichen Ge, Zhuojia Chen, Hongsheng Wang   +17 more
doaj   +2 more sources

Structural Analysis of the AlkB Family in Poultry [PDF]

Animals
The objective of this study was to identify the AlkB family genes in poultry using bioinformatics, and to explore their molecular characteristics, evolutionary relationships, and expression patterns to clarify their potential functions in poultry.
Yuling Niu, Kan Li, Xuerong You, Yutao Wu, Xue Du, Ayong Zhao, Zhijun Wang   +6 more
doaj   +2 more sources

The Role of Key Amino Acids of the Human Fe(II)/2OG-Dependent Dioxygenase ALKBH3 in Structural Dynamics and Repair Activity toward Methylated DNA. [PDF]

Int J Mol Sci
Non-heme dioxygenases of the AlkB family hold a unique position among enzymes that repair alkyl lesions in nucleic acids. These enzymes activate the Fe(II) ion and molecular oxygen through the coupled decarboxylation of the 2-oxoglutarate co-substrate to
Kanazhevskaya LY, Gorbunov AA, Lukina MV, Smyshliaev DA, Zhdanova PV, Lomzov AA, Koval VV.   +6 more
europepmc   +2 more sources

Deficiency of N1-Adenine Methyltransferase Aggravates RNA and Protein Aggregation [PDF]

Cells
RNA modifications regulate diverse aspects of transcripts’ function and stability. Among these, N1-methyladenine (m1A) is a reversible mark primarily installed by the TRMT6/TRMT61A methyltransferase on tRNA, though it is also found on other RNA types ...
Marion Alriquet, Roberto Arsiè, Giulia Calloni, Gian G. Tartaglia, R. Martin Vabulas   +4 more
doaj   +2 more sources

Human RAD51 paralogue RAD51C fosters repair of alkylated DNA by interacting with the ALKBH3 demethylase [PDF]

Nucleic Acids Research, 2019
The integrity of our DNA is challenged daily by a variety of chemicals that cause DNA base alkylation. DNA alkylation repair is an essential cellular defence mechanism to prevent the cytotoxicity or mutagenesis from DNA alkylating chemicals.
Monisha Mohan, Deepa Akula, A. Dhillon, A. Goyal, Roy Anindya   +4 more
semanticscholar   +4 more sources

The ASCC2 CUE domain in the ALKBH3–ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin [PDF]

Journal of Biological Chemistry, 2021
Alkylation of DNA and RNA is a potentially toxic lesion that can result in mutations and even cell death. In response to alkylation damage, K63-linked polyubiquitin chains are assembled that localize the Alpha-ketoglutarate-dependent dioxygenase alkB ...
P. Lombardi, S. Haile, Timur Rusanov, Rebecca Rodell, Rita Anoh, Julia G. Baer, Kate A. Burke, Lauren N. Gray, Abigail R. Hacker, Kayla R. Kebreau, Christine K. Ngandu, Hannah A. Orland, Emmanuella Osei-Asante, Dhane P. Schmelyun, Devin E. Shorb, Shaheer H. Syed, Julianna M. Veilleux, A. Majumdar, N. Mosammaparast, C. Wolberger   +19 more
semanticscholar   +4 more sources

Multiprotein Dynamic Combinatorial Chemistry: A Strategy for the Simultaneous Discovery of Subfamily-Selective Inhibitors for Nucleic Acid Demethylases FTO and ALKBH3. [PDF]

Chemistry - An Asian Journal, 2018
Dynamic combinatorial chemistry (DCC) is a powerful supramolecular approach for discovering ligands for biomolecules. To date, most, if not all, biologically templated DCC systems employ only a single biomolecule to direct the self-assembly process.
Mohua Das, Tianming Yang, Jinghua Dong, Fransisca Prasetya, Yiming Xie, Kendra H. Q. Wong, Adeline Cheong, E. Woon   +7 more
semanticscholar   +3 more sources

USP7 promotes temozolomide resistance by stabilizing MGMT in glioblastoma [PDF]

Cell Death and Disease
Glioblastoma (GBM), a World Health Organization (WHO) grade IV glioma, is one of the most lethal brain tumors, with a poor prognosis and limited treatment options.
Jiabing Li, Xiaorong Feng, Zhaohui Liu, Yunfang Deng, Zhiming Sun, Bei Chen, Lihui Wu, Xiaolong Wang, Lin Miao, Liyuan Zeng, Lei Hu, Yuming He, Ying Sheng, Yue Liu, Yu Zhao   +14 more
doaj   +2 more sources