Novel Metabolically Stable PCA-1/ALKBH3 Inhibitor Has Potent Antiproliferative Effects on DU145 Cells In Vivo. [PDF]
Anticancer Research, 2018 Novel potent prostate cancer antigen-1 (PCA-1)/alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3) inhibitors both in vivo and in vivo were designed and evaluated by a stability assay in an S9 mixture, a mixture of rat liver homogenate and co-factors, and oral absorbability assay in rat, as well as enzyme and cell assays, and resulted in ...
Masahiro Ueda +8 more
semanticscholar +3 more sources
Roles of Aag, Alkbh2, and Alkbh3 in the Repair of Carboxymethylated and Ethylated Thymidine Lesions [PDF]
ACS Chemical Biology, 2016 Environmental and endogenous genotoxic agents can result in a variety of alkylated and carboxymethylated DNA lesions, including N3-ethylthymidine (N3-EtdT), O(2)-EtdT, and O(4)-EtdT as well as N3-carboxymethylthymidine (N3-CMdT) and O(4)-CMdT. By using nonreplicative double-stranded vectors harboring a site-specifically incorporated DNA lesion, we ...
You, Changjun +6 more
openaire +4 more sources
Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA [PDF]
, 2018 The AlkB protein is a repair enzyme that uses an α-ketoglutarate/Fe(II)-dependent mechanism to repair alkyl DNA adducts. AlkB has been reported to repair highly susceptible substrates, such as 1-methyladenine and 3-methylcytosine, more efficiently in ss ...
Bian, Ke +8 more
core +1 more source
Function and clinical significance of N6-methyladenosine in digestive system tumours
Experimental Hematology & Oncology, 2021 RNA modification, like DNA methylation, histone modification, non-coding RNA modification and chromatin rearrangement, plays an important role in tumours.
Junchao Huang, Yingjie Shao, Wendong Gu
doaj +1 more source
The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations
Nature Communications, 2020 The DNA helicase ASCC3 is the largest subunit of the activating signal co-integrator complex (ASCC), and its DNA unwinding activity is required for the AlkBH3/ASCC-dependent DNA de-alkylation repair pathway.
Junqiao Jia +7 more
doaj +1 more source
Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney [PDF]
, 2014 Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induced DNA ...
Abolhassani, Nona +9 more
core +1 more source
The potential role of RNA N6-methyladenosine in Cancer progression
Molecular Cancer, 2020 N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA).
Tianyi Wang +3 more
doaj +1 more source
A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral response [PDF]
, 2013 The type I interferon (IFN) signaling pathway restricts infection of many divergent families of RNA and DNA viruses by inducing hundreds of IFN-stimulated genes (ISGs), some of which have direct antiviral activity.
Chandra, Sumit K +6 more
core +2 more sources
Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage [PDF]
, 2015 Environmental and metabolic sources of reactive oxygen species (ROS) can damage DNA, proteins and lipids to promote disease. Regulation of gene expression can prevent this damage and can include increased transcription, translation and post translational
Begley, Thomas J. +8 more
core +3 more sources
5′-tRF-GlyGCC: a tRNA-derived small RNA as a novel biomarker for colorectal cancer diagnosis
Genome Medicine, 2021 Background tRNA-derived small RNAs (tDRs), which are widely distributed in human tissues including blood and urine, play an important role in the progression of cancer. However, the expression of tDRs in colorectal cancer (CRC) plasma and their potential
Yingmin Wu +8 more
doaj +1 more source