Writers, readers and erasers of RNA modifications in cancer [PDF]
, 2020 Although cancer was originally considered a disease driven only by genetic mutations, it has now been proven that it is also an epigenetic disease driven by DNA hypermethylation-associated silencing of tumor suppressor genes and aberrant histone ...
Bueno Costa, Alberto +2 more
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Human targeted deletions and biological roles of genes involved in repair of alkylation damage [PDF]
, 2016 DNA repair is not a single mechanism found within cells. There exists numerous different DNA repair mechanisms that function within every type of cell. The majority of these mechanisms risk accumulating mutations.
Ahmad, Alya
core +1 more source
Exome-wide association study of pancreatic cancer risk [PDF]
, 2018 We conducted a case-control exome-wide association study to discover germline variants in coding regions that affect risk for pancreatic cancer, combining data from 5 studies. We analyzed exome and genome sequencing data from 437 patients with pancreatic
Biankin, Andrew +18 more
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The m6A reader YTHDF2 and m1A eraser ALKBH3 fine-tune mRNA transgene expression in CHO cells
, 2020 N6-methylated adenosine (m6A) and N1-methylated adenosine (m1A) are two epi-transcriptomic modifications on eukaryotic mRNA which have recently been rediscovered and are generating considerable interest. M6A methylation impacts on all aspects of cellular
N. Lao, N. Barron
semanticscholar +1 more source
Cancer Management and Research, 2021 Caiping Liu,1 Sheng Yang,1 Yanqiu Zhang,2 Chuntao Wang,3 Dandan Du,1 Xian Wang,1 Tong Liu,1 Geyu Liang1 1School of Public Health, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Southeast University, Nanjing, 210009, Jiangsu,
Liu C +7 more
doaj
The ASCC2 CUE domain in the ALKBH3-ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin [PDF]
, 2022 Alkylation of DNA and RNA is a potentially toxic lesion that can result in mutations and even cell death. In response to alkylation damage, K63-linked polyubiquitin chains are assembled that localize the Alpha-ketoglutarate-dependent dioxygenase alkB ...
et al, +4 more
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ASCC1 structures and bioinformatics reveal a novel helix-clasp-helix RNA-binding motif linked to a two-histidine phosphodiesterase [PDF]
Activating signal co-integrator complex 1 (ASCC1) acts with ASCC-ALKBH3 complex in alkylation damage responses. ASCC1 uniquely combines two evolutionarily ancient domains: nucleotide-binding K-Homology (KH) (associated with regulating splicing ...
Arvai, Andrew S +18 more
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Germline sequencing in men with metastatic castration-resistant prostate cancer from the BARCODE2 study reveals a wide range of pathogenic variants in DNA repair genes [PDF]
Background The presence of germline mutations plays an increasingly important role in risk assessment and treatment of prostate cancer (PrCa). Screening for high-risk mutations in subsets of patients is becoming routine.
Attard, G +31 more
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Detecting inosine in nanopore sequencing data with machine learning [PDF]
, 2021 Detecting modifications in DNA has been a long-standing challenge in understanding the workings of the genome, particularly with regards to regulatory function.
Stautland, Thomas Kristoffer
core
Smoking, Genetic Polymorphisms In Dna Repair Genes And Risk Of Thyroid Cancer [PDF]
, 2016 While the number of current smokers has declined due to legal and regulatory measures and public health awareness, cigarette smoking remains the top risk factor for many diseases, including cancers originated from various tissues.
Guo, Qi
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