Results 71 to 80 of about 1,461 (131)

Depletion of the m1A writer TRMT6/TRMT61A reduces proliferation and resistance against cellular stress in bladder cancer

Frontiers in Oncology
BackgroundBladder cancer (BLCA) is a common and deadly disease that results in a reduced quality of life for the patients and a significant economic burden on society. A better understanding of tumorigenesis is needed to improve clinical outcomes. Recent
Ida Monshaugen, Ida Monshaugen, Ida Monshaugen, Luisa Luna, Jayden Rhodes, Felicia Iselin Svensson Kristiansen, Felicia Iselin Svensson Kristiansen, Felicia Iselin Svensson Kristiansen, Anna Lång, Stig Ove Bøe, Anindya Dutta, Zhangli Su, Arne Klungland, Arne Klungland, Rune Ougland, Rune Ougland   +15 more
doaj   +1 more source

Rare variant analyses validate known ALS genes in a multi-ethnic population and identifies ANTXR2 as a candidate in PLS

BMC Genomics
Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting over 300,000 people worldwide. It is characterized by the progressive decline of the nervous system that leads to the weakening of muscles which impacts physical ...
Tess D. Pottinger, Joshua E. Motelow, Gundula Povysil, Cristiane A. Martins Moreno, Zhong Ren, Hemali Phatnani, The New York Genome Center ALS Sequencing Consortium, Timothy J. Aitman, Javier Santoyo-Lopez, Scottish Genomes Partnership, Hiroshi Mitsumoto, ALS COSMOS Study Group, PLS COSMOS Study Group, GTAC Investigators, David B. Goldstein, Matthew B. Harms   +15 more
doaj   +1 more source

Emerging Roles of N6-Methyladenosine Demethylases and Its Interaction with Environmental Toxicants in Digestive System Cancers

Cancer Management and Research, 2021
Caiping Liu,1 Sheng Yang,1 Yanqiu Zhang,2 Chuntao Wang,3 Dandan Du,1 Xian Wang,1 Tong Liu,1 Geyu Liang1 1School of Public Health, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Southeast University, Nanjing, 210009, Jiangsu,
Liu C, Yang S, Zhang Y, Wang C, Du D, Wang X, Liu T, Liang G   +7 more
doaj  

Xist interacts with Alkbh3.

We measured total transcription in cells in concert with N1-methyladenosine (m1A) profiling, in cells with intact Albkh3 and in cells lacking Alkbh3. We report here interaction of the non-coding RNA Xist with Alkbh3. 
openaire   +2 more sources

Alkbh3 functions with Nupr1 in a n1-methyladenosine dependent manner.

We measured total in conjunction with N1-methyladenosine marks in human cells lacking Alkbh3 to understand function of the m1A mark in transcriptional biology and the immune system. We demonstrate here interaction of Alkbh3 with Nupr1.     
openaire   +1 more source

Research progress of N1-methyladenosine RNA modification in cancer

Cell Communication and Signaling
N1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation.
Yafeng Liu, Shujun Zhang, Xiaohui Gao, Yi Ru, Xinyu Gu, Xinjun Hu   +5 more
doaj   +1 more source

A multi-type programmed cell death gene signature predicts survival and reveals therapeutic targets in osteosarcoma

Discover Oncology
Background Osteosarcoma (OS) is an aggressive bone tumor with poor outcomes in advanced stages. Programmed cell death (PCD) plays a crucial role in tumor biology, but the prognostic value of integrating multiple PCD-related genes in OS remains ...
Chunyang Wu
doaj   +1 more source

The Molecular Basis of Human ALKBH3 Mediated RNA N¹ -methyladenosine (m¹ A) Demethylation. [PDF]

Angew Chem Int Ed Engl
AbstractN1‐methyladenosine (m1A) is a prevalent post‐transcriptional RNA modification, and the distribution and dynamics of the modification play key epitranscriptomic roles in cell development. At present, the human AlkB Fe(II)/α‐ketoglutarate‐dependent dioxygenase family member ALKBH3 is the only known mRNA m1A demethylase, but its catalytic ...
Zhang L, Duan HC, Paduch M, Hu J, Zhang C, Mu Y, Lin H, He C, Kossiakoff AA, Jia G, Zhang L.   +10 more
europepmc   +3 more sources

Improving the bioavailability and anticancer effect of the PCA-1/ALKBH3 inhibitor HUHS015 using sodium salt.

In vivo (Athens, Greece), 2015
Prostate cancer antigen (PCA)-1/AlkB homologue 3 (ALKBH3) has been identified as a clinically significant factor and siRNA of PCA-1 inhibits DU145 proliferation both in vitro and in vivo. HUHS015 ( 1: ), a previous reported PCA-1 small-molecule inhibitor, was also effective without any obvious side-effects or toxicity.
Miyuki, Mabuchi, Tadashi, Shimizu, Masahiro, Ueda, Yuka, Sasakawa, Syuhei, Nakao, Yuko, Ueda, Akio, Kawamura, Kazutake, Tsujikawa, Akito, Tanaka   +8 more
openaire   +1 more source

Genetic and Epigenetic Biomarkers Associated with Early Relapse in Pediatric Acute Lymphoblastic Leukemia: A Focused Bioinformatics Study on DNA-Repair Genes

Biomedicines
Genomic instability is one of the main drivers of tumorigenesis and the development of hematological malignancies. Cancer cells can remedy chemotherapeutic-induced DNA damage by upregulating DNA-repair genes and ultimately inducing therapy resistance ...
Walaa F. Albaqami, Ali A. Alshamrani, Ali A. Almubarak, Faris E. Alotaibi, Basil Jamal Alotaibi, Abdulrahman M. Alanazi, Moureq R. Alotaibi, Ali Alhoshani, Homood M. As Sobeai   +8 more
doaj   +1 more source