Results 71 to 80 of about 2,197 (160)

Chemistry meets biology in colitis-associated carcinogenesis [PDF]

, 2013
The intestine comprises an exceptional venue for a dynamic and complex interplay of numerous chemical and biological processes. Here, multiple chemical and biological systems, including the intestinal tissue itself, its associated immune system, the gut ...
Dedon, Peter C., Fox, James G., Mangerich, Aswin, Tannenbaum, Steven Robert, Wogan, Gerald N.   +4 more
core   +1 more source

The histone demethylase LSD1/KDM1A promotes the DNA damage response [PDF]

, 2013
Histone demethylation is known to regulate transcription, but its role in other processes is largely unknown. We report a role for the histone demethylase LSD1/KDM1A in the DNA damage response (DDR).
Acs, Bedford, Benoit Laurent, Berkovich, Berkovich, Bohgaki, Borde, Bruce Yankner, Bunting, Celeste, Cheung, Chiolo, Chou, Ciccia, Cloos, Coster, Dango, Daniel, Doil, FitzGerald, Fradet-Turcotte, Garcia-Bassets, Gatti, Ginjala, Haeyoung Kim, Hakimi, Hakimi, Hanno Steen, Huang, Huen, Huen, Hui Jun Lim, Ismail, J. Wade Harper, Jackson, Klose, Kolas, Kristina Hempel, Larsen, Lee, Luijsterburg, Lv, Mailand, Mallette, Mathew E. Sowa, Mattiroli, Meerang, Metzger, Miller, Mona C. Majid, Mosammaparast, Mulligan, Murr, Nakatani, Nima Mosammaparast, Nottke, Polo, Sakaue-Sawano, Scoumanne, Sebastian Dango, Shanbhag, Shi, Shi, Smeenk, Sommermeyer, Steven P. Gygi, Stewart, Stewart, Strahl, Stucki, Toledo, van Attikum, Wang, Wang, Wang, Ward, Weinstock, Xie, Yang, Yang Shi, You, Yu Zhao, Yuying Luo, Zibetti, Ziv   +84 more
core   +2 more sources

m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in Gastrointestinal Cancer

Translational Oncology, 2019
BACKGROUND: Gene expression can be posttranscriptionally regulated by a complex network of proteins. N1-methyladenosine (m1A) is a newly validated RNA modification.
Yueshui Zhao, Qijie Zhao, Parham Jabbarzadeh Kaboli, Jing Shen, Mingxing Li, Xu Wu, Jianhua Yin, Hanyu Zhang, Yuanlin Wu, Ling Lin, Lingling Zhang, Lin Wan, Qinglian Wen, Xiang Li, Chi Hin Cho, Tao Yi, Jing Li, Zhangang Xiao   +17 more
doaj   +1 more source

Identification of novel HIV-1 dependency factors in primary CCR4+CCR6+Th17 cells via a genome-wide transcriptional approach [PDF]

, 2015
Additional file 2: Table S2. The complete list of genes down regulated in Th17 versus Th1 subsets are included and classified based on p-values 
Annie Gosselin, Aurélie Cleret-Buhot, Cécile L. Tremblay, Delphine Planas, Elias K. Haddad, Jean-Philippe Goulet, Jean-Pierre Routy, Mohamed El-Far, Mohammad-Ali Jenabian, Nicolas Chomont, Patricia Monteiro, Petronela Ancuta, Rafick-Pierre Sekaly, Vanessa Sue Wacleche, Yuwei Zhang   +14 more
core   +6 more sources

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro

Nucleic Acids Research, 2019
5-Methylcytosine (5mC) in DNA CpG islands is an important epigenetic biomarker for mammalian gene regulation. It is oxidized to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) by the ten-eleven translocation (TET ...
Ke Bian, S. Lenz, Qi Tang, Fangyi Chen, Rui Qi, M. Jost, C. Drennan, J. Essigmann, S. Wetmore, Deyu Li   +9 more
semanticscholar   +1 more source

Clinical significance of ALKBH4 expression in non-small cell lung cancer [PDF]

, 2022
Background: Gene methylation is deeply involved in epigenetics and affects both the development and maintenance of homeostasis and carcinogenesis. ALKBH4 is a member of the AlkB homolog (ALKBH) family that controls demethylation of DNA and RNA.
142800, 142801, 142802, 142803, 142804, 142805, 142806, 142807, 142808, 142809, 142810, 142811, 142812, 142813, 142814, 142815, 142816, Aoki, Masaya, Furukawa, Tatsuhiko, Harada－Takeda, Aya, Ikehata, Mizuki, Iwamoto, Yoshiyuki, Kamimura, Go, Kariatsumari, Kota, Maeda, Koki, Morizono, Shoichiro, Nagata, Toshiyuki, Sakagami, Yuri, Sato, Masami, Tabata, Keisuke, Tokunaga, Takuya, Tsujikawa, Kazutake, Ueda, Kazuhiro, Umehara, Tadashi   +33 more
core  

Evaluation of Anti-cancer Activity of Stilbene and Methoxydibenzo[b,f] oxepin Derivatives [PDF]

, 2017
Background: Stilbenes, 1,2-diphenylethen derivatives, including resveratrol and combretastatins, show anticancer features especially against tumor angiogenesis. Fosbretabulin, CA-4, in combination with carboplatin, is in the last stages of clinical tests
Dębski, Janusz, Garbicz, Damian, Grzesiuk, Elzbieta, Krawczyk, Hanna, Marcinkowski, Michał, Mielecki, Damian, Palak, Ewelina, Pilżys, Tomasz, Piwowarski, Jan, Szczeciński, Przemysław, Wrzesiński, Michał   +10 more
core  

Massenspektrometrische Methoden zur Untersuchung enzymatisch modifizierter RNA [PDF]

, 2021
Die Dynamik von RNA-Modifikationen ist im Bereich der Epitranskriptom-Forschung von zentraler Bedeutung. Die Wichtigkeit von RNA-modifizierenden Enzymen, welche die RNA-Modifikationsdichte beeinflussen, wird insbesondere deutlich, wenn man die Verbindung
Hagelskamp, Felix
core  

Depletion of the m1A writer TRMT6/TRMT61A reduces proliferation and resistance against cellular stress in bladder cancer

Frontiers in Oncology
BackgroundBladder cancer (BLCA) is a common and deadly disease that results in a reduced quality of life for the patients and a significant economic burden on society. A better understanding of tumorigenesis is needed to improve clinical outcomes. Recent
Ida Monshaugen, Ida Monshaugen, Ida Monshaugen, Luisa Luna, Jayden Rhodes, Felicia Iselin Svensson Kristiansen, Felicia Iselin Svensson Kristiansen, Felicia Iselin Svensson Kristiansen, Anna Lång, Stig Ove Bøe, Anindya Dutta, Zhangli Su, Arne Klungland, Arne Klungland, Rune Ougland, Rune Ougland   +15 more
doaj   +1 more source

Prognostic and biological implications of epigenetic changes in leukemia [PDF]

, 2012
The field of epigenetic research in hematology and oncology is rapidly expanding. Even so, reliable data linking epigenetic changes to clinical outcomes are scarce. We conducted two retrospective studies in AML. The first (paper I) was performed in 107
Deneberg, Stefan
core   +1 more source