Results 71 to 80 of about 1,458 (131)

A multi-type programmed cell death gene signature predicts survival and reveals therapeutic targets in osteosarcoma

Discover Oncology
Background Osteosarcoma (OS) is an aggressive bone tumor with poor outcomes in advanced stages. Programmed cell death (PCD) plays a crucial role in tumor biology, but the prognostic value of integrating multiple PCD-related genes in OS remains ...
Chunyang Wu
doaj   +1 more source

Genetic and Epigenetic Biomarkers Associated with Early Relapse in Pediatric Acute Lymphoblastic Leukemia: A Focused Bioinformatics Study on DNA-Repair Genes

Biomedicines
Genomic instability is one of the main drivers of tumorigenesis and the development of hematological malignancies. Cancer cells can remedy chemotherapeutic-induced DNA damage by upregulating DNA-repair genes and ultimately inducing therapy resistance ...
Walaa F. Albaqami, Ali A. Alshamrani, Ali A. Almubarak, Faris E. Alotaibi, Basil Jamal Alotaibi, Abdulrahman M. Alanazi, Moureq R. Alotaibi, Ali Alhoshani, Homood M. As Sobeai   +8 more
doaj   +1 more source

Improving the bioavailability and anticancer effect of the PCA-1/ALKBH3 inhibitor HUHS015 using sodium salt.

In vivo (Athens, Greece), 2015
Prostate cancer antigen (PCA)-1/AlkB homologue 3 (ALKBH3) has been identified as a clinically significant factor and siRNA of PCA-1 inhibits DU145 proliferation both in vitro and in vivo. HUHS015 ( 1: ), a previous reported PCA-1 small-molecule inhibitor, was also effective without any obvious side-effects or toxicity.
Miyuki, Mabuchi, Tadashi, Shimizu, Masahiro, Ueda, Yuka, Sasakawa, Syuhei, Nakao, Yuko, Ueda, Akio, Kawamura, Kazutake, Tsujikawa, Akito, Tanaka   +8 more
openaire   +1 more source

Biomarker in primären Glioblastomen und Gliomen : prognostische Relevanz von AGTRAP, ALKBH3 und Diversin

Ziel der Studie war es, neue Proteine als prognostische Biomarker in primären Glioblastomen und Gliomen zu identifizieren. Dafür wurden die Proteine AGTRAP, ALKBH3 und Diversin immunhistochemisch in WHO II-III Gliomgewebe und Glioblastomgewebe angefärbt und analysiert.
openaire   +2 more sources

Xist interacts with Alkbh3.

We measured total transcription in cells in concert with N1-methyladenosine (m1A) profiling, in cells with intact Albkh3 and in cells lacking Alkbh3. We report here interaction of the non-coding RNA Xist with Alkbh3. 
openaire   +1 more source

Additional file 2 of m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA

Supplementary Material ...
Wang, Huan, Xie, Linjie, Guo, Haomin, Li, Lishi, Chen, Shuwei, Fan, Ye, Tian, Jingyuan, Xu, Liping, Kong, Xuejian, Xuan, Aiguo   +9 more
openaire   +1 more source

Identification of Novel Alternative Transcripts of the Human ALKBH Gene Family and Investigation of Their Unique Expression Signatures in Cancer Cells. [PDF]

Curr Issues Mol Biol
Athanasopoulou K, Michalopoulou VI, Tsiakanikas P, Scorilas A, Adamopoulos PG.   +4 more
europepmc   +1 more source

Pseudorabies virus infection reshapes the host epitranscriptome by globally suppressing but selectively elevating specific RNA modifications. [PDF]

Front Microbiol
Wang Y, Wang Q, Zhong J, Mao F, Liu X, Meng F, Chen X.   +6 more
europepmc   +1 more source

Alkbh3 functions with Nupr1 in a n1-methyladenosine dependent manner.

We measured total in conjunction with N1-methyladenosine marks in human cells lacking Alkbh3 to understand function of the m1A mark in transcriptional biology and the immune system. We demonstrate here interaction of Alkbh3 with Nupr1.     
openaire   +1 more source

Accurate prediction of candidate lncRNAs associated with DNA damage response based on gene expression patterns from graph neural networks. [PDF]

Bioinform Adv
Shah S, Wang L.
europepmc   +1 more source