Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine [PDF]
Frontiers in Cell and Developmental Biology, 2021 RNA methylation is considered a significant epigenetic modification, a process that does not alter gene sequence but may play a necessary role in multiple biological processes, such as gene expression, genome editing, and cellular differentiation.
Yating Xu +24 more
doaj +2 more sources
RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis [PDF]
Nature Communications, 2018 Mutations in mitochondrially-encoded tRNA genes can lead to mitochondrial disorders. Here the authors use next generation RNA sequencing to reveal the role of a N1 -methyladenosine modification in tRNALys MERR patients for translation elongation and the ...
Uwe Richter +9 more
doaj +13 more sources
N1-methyladenosine methylation-related metabolic genes signature and subtypes for predicting prognosis and immune microenvironment in osteosarcoma [PDF]
Frontiers in Genetics, 2022 N1-methyladenosine methylation (m1A), as an important RNA methylation modification, regulates the development of many tumours. Metabolic reprogramming is one of the important features of tumour cells, and it plays a crucial role in tumour development and
Guowei Wang +6 more
doaj +2 more sources
N1-methyladenosine modification in cancer biology: Current status and future perspectives [PDF]
Computational and Structural Biotechnology Journal, 2022 Post-transcriptional modifications in RNAs regulate their biological behaviors and functions. N1-methyladenosine (m1A), which is dynamically regulated by writers, erasers and readers, has been found as a reversible modification in tRNA, mRNA, rRNA and ...
Jiexin Li +2 more
doaj +2 more sources
Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA [PDF]
Genomics, Proteomics & Bioinformatics, 2018 More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins.
Chi Zhang, Guifang Jia
doaj +2 more sources
Research progress of N1-methyladenosine RNA modification in cancer [PDF]
Cell Communication and SignalingN1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation.
Yafeng Liu +5 more
doaj +2 more sources
Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer [PDF]
Frontiers in Immunology, 2021 Backgroundrecently, many researches have concentrated on the relevance between N1-methyladenosine (m1A) methylation modifications and tumor progression and prognosis.
Jinhui Liu +6 more
doaj +2 more sources
RNA N1-methyladenosine regulator-mediated methylation modification patterns and heterogeneous signatures in glioma. [PDF]
Front Immunol, 2022 N1-methyladenosine (m1A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m1A modification-related patterns based on m1A regulators in the TCGA (The Cancer
Mao M, Chu Q, Lou Y, Lv P, Wang LJ.
europepmc +3 more sources
Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein [PDF]
Advanced ScienceMitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and ...
Xiangrui Li +13 more
doaj +2 more sources
The metabolites for muscle and osteoclast activity are indicators of femoral neck osteoporosis [PDF]
Scientific ReportsFemoral neck osteoporosis is a critical risk factor for a bedbound state, which significantly decreases overall life expectancy, if a patient falls and suffers a fracture.
Masahiro Kameda +2 more
doaj +2 more sources