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Research progress of N1-methyladenosine RNA modification in cancer [PDF]

Cell Communication and Signaling
N1-methyladenosine (m1A) is a post-transcriptionally modified RNA molecule that plays a pivotal role in the regulation of various biological functions and activities. Especially in cancer cell invasion, proliferation and cell cycle regulation.
Yafeng Liu, Shujun Zhang, Xiaohui Gao, Yi Ru, Xinyu Gu, Xinjun Hu   +5 more
doaj   +4 more sources

Role of Main RNA Methylation in Hepatocellular Carcinoma: N6-Methyladenosine, 5-Methylcytosine, and N1-Methyladenosine [PDF]

Frontiers in Cell and Developmental Biology, 2021
RNA methylation is considered a significant epigenetic modification, a process that does not alter gene sequence but may play a necessary role in multiple biological processes, such as gene expression, genome editing, and cellular differentiation.
Yating Xu, Yating Xu, Yating Xu, Yating Xu, Menggang Zhang, Menggang Zhang, Menggang Zhang, Menggang Zhang, Qiyao Zhang, Qiyao Zhang, Qiyao Zhang, Qiyao Zhang, Xiao Yu, Xiao Yu, Xiao Yu, Xiao Yu, Zongzong Sun, Yuting He, Yuting He, Yuting He, Yuting He, Wenzhi Guo, Wenzhi Guo, Wenzhi Guo, Wenzhi Guo   +24 more
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Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer [PDF]

Frontiers in Immunology, 2021
Backgroundrecently, many researches have concentrated on the relevance between N1-methyladenosine (m1A) methylation modifications and tumor progression and prognosis.
Jinhui Liu, Can Chen, Yichun Wang, Cheng Qian, Junting Wei, Yan Xing, Jianling Bai   +6 more
doaj   +5 more sources

N1-methyladenosine methylation-related metabolic genes signature and subtypes for predicting prognosis and immune microenvironment in osteosarcoma [PDF]

Frontiers in Genetics, 2022
N1-methyladenosine methylation (m1A), as an important RNA methylation modification, regulates the development of many tumours. Metabolic reprogramming is one of the important features of tumour cells, and it plays a crucial role in tumour development and
Guowei Wang, Hongyi Wang, Sha Cheng, Xiaobo Zhang, Wanjiang Feng, Pan Zhang, Jianlong Wang   +6 more
doaj   +4 more sources

N1-methyladenosine modification in cancer biology: Current status and future perspectives [PDF]

Computational and Structural Biotechnology Journal, 2022
Post-transcriptional modifications in RNAs regulate their biological behaviors and functions. N1-methyladenosine (m1A), which is dynamically regulated by writers, erasers and readers, has been found as a reversible modification in tRNA, mRNA, rRNA and ...
Jiexin Li, Haisheng Zhang, Hongsheng Wang   +2 more
doaj   +4 more sources

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein [PDF]

Advanced Science
Mitochondrial RNA N1‐methyladenosine (m1A) is a prevalent and reversible epitranscriptomic modification. While the biological roles of cytosolic m1A have been increasingly understood, the causal relationship between site‐specific mitochondrial m1A and ...
Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li   +13 more
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Gene Expression Profile of RNA N1-methyladenosine methyltransferases [PDF]

E3S Web of Conferences, 2020
N1-methyladenosine (m1A) is a kind of common and abundant methylation modification in eukaryotic mRNA and long-chain non-coding RNA. Nucleoside methyltransferase (MTase) of m1A is a diverse protein family, which is characterized by the presence of ...
Rao Mingzhu
doaj   +2 more sources

Epitranscriptomic Stability—Variable Extents of N1-Methyladenosine to N6-Methyladenosine Conversion Under Different Experimental Conditions [PDF]

Biomolecules
The growing interest in epitranscriptomes has emphasized the need for accurate quantification of RNA modifications. However, the stability of RNA modifications under different experimental conditions remains poorly characterized. In this study, we use N1-
Frank Morales Shnaider, Hasna Kanan, Shrikant Patel, Norman H. L. Chiu   +3 more
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Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA [PDF]

Genomics, Proteomics & Bioinformatics, 2018
More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins.
Chi Zhang, Guifang Jia
doaj   +2 more sources

The metabolites for muscle and osteoclast activity are indicators of femoral neck osteoporosis [PDF]

Scientific Reports
Femoral neck osteoporosis is a critical risk factor for a bedbound state, which significantly decreases overall life expectancy, if a patient falls and suffers a fracture.
Masahiro Kameda, Mitsuhiro Yanagida, Hiroshi Kondoh   +2 more
doaj   +2 more sources