Results 11 to 20 of about 237 (128)
Evolution of a reverse transcriptase to map N1-methyladenosine in human messenger RNA [PDF]
Nature Methods, 2019 Chemical modifications to messenger RNA are increasingly recognized as a critical regulatory layer in the flow of genetic information, but quantitative tools to monitor RNA modifications in a whole-transcriptome and site-specific manner are lacking.
Huiqing Zhou +8 more
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Nature Communications, 2022 RNA modifications are important regulators of RNA biology. Here we report N1-methyladenosine (m1A) enrichment on 22-nucleotide tRNA fragments and its effect on gene-silencing.
Zhangli Su +6 more
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Dynamic regulation and key roles of ribonucleic acid methylation
Frontiers in Cellular Neuroscience, 2022 Ribonucleic acid (RNA) methylation is the most abundant modification in biological systems, accounting for 60% of all RNA modifications, and affects multiple aspects of RNA (including mRNAs, tRNAs, rRNAs, microRNAs, and long non-coding RNAs ...
Jia Zou +14 more
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Research progress on mRNA methylation and diseases [PDF]
Jichu yixue yu linchuang, 2021 mRNA methylation modification, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A), etc., represents more than 60% of all mRNA modifications and varies distribution on mRNA.
LI Ran, HAO Yan-lei
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Cancers, 2023 N1-methyladenosine (m1A) and long non-coding RNAs (lncRNAs) play significant roles in tumor progression in hepatocellular carcinoma (HCC). However, their association with HCC is still unclear. In this study, lncRNAs related to m1A were extracted from the mRNA expression matrix in The Cancer Genome Atlas (TCGA) database.
Song, Danjun +6 more
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Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis
Frontiers in Genetics, 2022 As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate.
Hui-Ming Chen +9 more
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Recent Advances in Identification of RNA Modifications
Non-Coding RNA, 2016 RNA modifications are involved in a broad spectrum of biological and physiological processes. To reveal the functions of RNA modifications, it is important to accurately predict their positions.
Wei Chen, Hao Lin
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Frontiers in Immunology, 2022 N1-methyladenosine (m1A) is ubiquitous in eukaryotic RNA and regulates mRNA translation. However, little is known about its regulatory role in glioma. Here, we identified 4 m1A modification-related patterns based on m1A regulators in the TCGA (The Cancer Genome Atlas) and CGGA (Chinese Glioma Genome Atlas) cohorts. The differences in survival prognosis
Meng Mao +8 more
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Reversible RNA Modification N1-methyladenosine (m1A) in mRNA and tRNA
Genomics, Proteomics & Bioinformatics, 2018 More than 100 modifications have been found in RNA. Analogous to epigenetic DNA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins.
Chi Zhang, Guifang Jia
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Nature Communications, 2023 Internal modifications of mRNA have emerged as widespread and versatile regulatory mechanism to control gene expression at the post-transcriptional level.
Katja Hartstock +8 more
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