Results 11 to 20 of about 4,267 (193)

Gene Expression Profile of RNA N1-methyladenosine methyltransferases [PDF]

E3S Web of Conferences, 2020
N1-methyladenosine (m1A) is a kind of common and abundant methylation modification in eukaryotic mRNA and long-chain non-coding RNA. Nucleoside methyltransferase (MTase) of m1A is a diverse protein family, which is characterized by the presence of ...
Rao Mingzhu
doaj   +2 more sources

Integrated Analysis of N1-Methyladenosine Methylation Regulators-Related lncRNAs in Hepatocellular Carcinoma. [PDF]

Cancers (Basel), 2023
N1-methyladenosine (m1A) and long non-coding RNAs (lncRNAs) play significant roles in tumor progression in hepatocellular carcinoma (HCC). However, their association with HCC is still unclear. In this study, lncRNAs related to m1A were extracted from the mRNA expression matrix in The Cancer Genome Atlas (TCGA) database.
Song D, Wang X, Wang Y, Liang W, Luo J, Zheng J, Zhu K.   +6 more
europepmc   +3 more sources

RNA modifications in peripheral blood are associated with acute coronary syndrome [PDF]

Journal of Molecular and Cellular Cardiology Plus
Acute coronary syndromes (ACS) trigger inflammatory and immune reactions, yet whether this response is associated with changes in RNA modifications remains poorly understood.
Miron Sopic, Victoria Stopa, Jelena Munjas, Aleksandar Davidović, Luka Vukmirović, Dane Cvijanović, Marko Milanov, Fabio Martelli, François Bernardin, Nathalie Michelle Legrave, Yvan Devaux   +10 more
doaj   +2 more sources

Establishment of a N1-methyladenosine-related risk signature for breast carcinoma by bioinformatics analysis and experimental validation. [PDF]

Breast Cancer, 2023
AbstractObjectivesBreast carcinoma (BRCA) has resulted in a huge health burden globally. N1-methyladenosine (m1A) RNA methylation has been proven to play key roles in tumorigenesis. Nevertheless, the function of m1A RNA methylation-related genes in BRCA is indistinct.MethodsThe RNA sequencing (RNA-seq), copy-number variation (CNV), single-nucleotide ...
Li L, Yang W, Jia D, Zheng S, Gao Y, Wang G.   +5 more
europepmc   +3 more sources

Deprotection of N1-methyladenosine-containing RNA using triethylamine hydrogen fluoride. [PDF]

Nucleosides Nucleotides Nucleic Acids
The N1-methyladenosine (m1A) epigenetic modification exists in many RNAs and is related to many human diseases. Chemically synthesized RNAs containing the modification are required for projects aimed at studying biological processes, mechanisms, and pathogenesis related to m1A.
Apostle A, Fang S.
europepmc   +4 more sources

ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17. [PDF]

Acta Pharm Sin B, 2023
Pulmonary hypertension (PH) is an extremely malignant pulmonary vascular disease of unknown etiology. ADAR1 is an RNA editing enzyme that converts adenosine in RNA to inosine, thereby affecting RNA expression. However, the role of ADAR1 in PH development remains unclear.
Zhang J, Li Y, Zhang J, Liu L, Chen Y, Yang X, Liao X, He M, Jia Z, Fan J, Bian JS, Nie X.   +11 more
europepmc   +4 more sources

Blood N1-methyladenosine (m¹A) RNA modification and outcome after cardiac arrest. [PDF]

Crit Care
Abstract: Background: Cardiac arrest (CA) is a leading cause of mortality and neurological disability. Prediction of post-CA outcomes is challenging. Epitranscriptomic (RNA) modifications are emerging as potential biomarkers due to their regulatory roles in RNA metabolism and disease progression.
Stopa V, Sopic M, Bernardin F, Legrave NM, Zhang L, Stammet P, Devaux Y.   +6 more
europepmc   +4 more sources

N1-Methyladenosine (m1A) Regulation Associated With the Pathogenesis of Abdominal Aortic Aneurysm Through YTHDF3 Modulating Macrophage Polarization. [PDF]

Front Cardiovasc Med, 2022
ObjectivesThis study aimed to identify key AAA-related m1A RNA methylation regulators and their association with immune infiltration in AAA. Furthermore, we aimed to explore the mechanism that m1A regulators modulate the functions of certain immune cells as well as the downstream target genes, participating in the progression of AAA.MethodsBased on the
Wu Y, Jiang D, Zhang H, Yin F, Guo P, Zhang X, Bian C, Chen C, Li S, Yin Y, Böckler D, Zhang J, Han Y.   +12 more
europepmc   +6 more sources

N1-Methyladenosine-Related lncRNAs Are Potential Biomarkers for Predicting Prognosis and Immune Response in Uterine Corpus Endometrial Carcinoma. [PDF]

Oxid Med Cell Longev, 2022
Uterine corpus endometrial carcinoma (UCEC) is a malignant disease that, at present, has no well‐characterised prognostic biomarker. In this study, two clusters were identified based on 28 N1‐methyladenosine‐ (m1A‐) related long noncoding RNAs (lncRNAs), of which cluster 1 was related to immune pathways according to the results of an enrichment ...
Liu J, Geng R, Zhong Z, Zhang Y, Ni S, Liu W, Du M, Bai J.   +7 more
europepmc   +3 more sources

Integrative analysis of bulk and single-cell RNA sequencing data reveals distinct subtypes of MAFLD based on N1-methyladenosine regulator expression. [PDF]

Liver Res, 2023
Metabolic dysfunction-associated fatty liver disease (MAFLD) is now the most prevalent chronic liver disease worldwide, with an increasing incidence rate. MAFLD is a heterogeneous disease that can have a low or high-risk profile for developing severe liver disease in its natural course.
He J, Xiao C, Li C, Yang F, Du C.
europepmc   +4 more sources