Results 31 to 40 of about 237 (128)

Blood N1-methyladenosine (m1A) RNA modification and outcome after cardiac arrest [PDF]

Critical Care
Abstract Background Cardiac arrest (CA) is a leading cause of mortality and neurological disability. Prediction of post-CA outcomes is challenging. Epitranscriptomic (RNA) modifications are emerging as potential biomarkers due to their regulatory roles in RNA metabolism and disease progression.
Stopa, Victoria, Sopić, Miron, Bernardin, François, Legrave, Nathalie M., Zhang, Lu, Stammet, Pascal, Devaux, Yvan   +6 more
openaire   +4 more sources

N1-Methyladenosine (m1A) Regulation Associated With the Pathogenesis of Abdominal Aortic Aneurysm Through YTHDF3 Modulating Macrophage Polarization

Frontiers in Cardiovascular Medicine, 2022
ObjectivesThis study aimed to identify key AAA-related m1A RNA methylation regulators and their association with immune infiltration in AAA. Furthermore, we aimed to explore the mechanism that m1A regulators modulate the functions of certain immune cells as well as the downstream target genes, participating in the progression of AAA.MethodsBased on the
Wu, Yihao, Jiang, Deying, Zhang, Hao, Yin, Fanxing, Guo, Panpan, Zhang, Xiaoxu, Bian, Ce, Chen, Chen, Li, Shuixin, Yin, Yuhan, Böckler, Dittmar, Zhang, Jian, Han, Yanshuo   +12 more
openaire   +5 more sources

The N¹-Methyladenosine Methylome of Petunia mRNA [PDF]

Plant Physiology, 2020
N1-methyladenosine is a unique type of base methylation in that it blocks Watson-Crick base pairing and introduces a positive charge. m1A is prevalent in yeast and mammalian mRNA and plays a functional role. However, little is known about the abundance, dynamics, and topology of this modification in plant mRNA.
Weiyuan Yang, Jie Meng, Juanxu Liu, Beibei Ding, Tao Tan, Qian Wei, Yixun Yu   +6 more
openaire   +2 more sources

N1-Methyladenosine detection with CRISPR-Cas13a/C2c2

Chemical Science, 2019
CRISPR Cas13a provided a robust, simple and fluorescence-based method for m1A detection and dynamic m1A demethylation analysis of 28S rRNA.
Yi Chen, Shixi Yang, Shuang Peng, Wei Li, Fan Wu, Qian Yao, Fang Wang, Xiaocheng Weng, Xiang Zhou   +8 more
openaire   +3 more sources

The potential regulatory role of RNA methylation in ovarian cancer

RNA Biology, 2023
Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao, Mengxue Zhang, Xiaolan Zhu, Jie Xing, Jiaming Zhou, Xinming Yin   +5 more
doaj   +1 more source

Research advances of mRNA methylation in kidney diseases

Linchuang shenzangbing zazhi
Recently mRNA methylation modification has been extensively examined, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A).
Shi-wen Zhang, Jun-jun Luan, Hua Zhou
doaj   +1 more source

Emerging roles of RNA methylation in gastrointestinal cancers

Cancer Cell International, 2020
RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression ...
Shanshan Xie, Wenwen Chen, Kanghua Chen, Yongxia Chang, Feng Yang, Aifu Lin, Qiang Shu, Tianhua Zhou, Xiaoyi Yan   +8 more
doaj   +1 more source

Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma

Frontiers in Pharmacology, 2021
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood.
Xing-xing Huo, Xing-xing Huo, Shu-jie Wang, Hang Song, Ming-de Li, Hua Yu, Meng Wang, Hong-xiao Gong, Xiao-ting Qiu, Yong-fu Zhu, Jian-ye Zhang   +10 more
doaj   +1 more source

Deprotection of N1-methyladenosine-containing RNA using triethylamine hydrogen fluoride

Nucleosides, Nucleotides & Nucleic Acids
The N1-methyladenosine (m1A) epigenetic modification exists in many RNAs and is related to many human diseases. Chemically synthesized RNAs containing the modification are required for projects aimed at studying biological processes, mechanisms, and pathogenesis related to m1A.
Apostle, A., Fang, S.
openaire   +3 more sources

The role of RNA modification in hepatocellular carcinoma

Frontiers in Pharmacology, 2022
Hepatocellular carcinoma (HCC) is a highly mortal type of primary liver cancer. Abnormal epigenetic modifications are present in HCC, and RNA modification is dynamic and reversible and is a key post-transcriptional regulator.
Qiang Feng, Dongxu Wang, Tianyi Xue, Chao Lin, Yongjian Gao, Liqun Sun, Ye Jin, Dianfeng Liu   +7 more
doaj   +1 more source