Results 21 to 30 of about 237 (128)

N1-methyladenosine methylation in mRNAs drives bladder cancer progression

, 2023
Abstract With the growing recognition of RNA modification as a hallmark of cancer, N1-methyladenosine (m1A) methylation has been reported as a key mechanism of post-transcriptional regulation. However, the molecular mechanisms underlying m1A modification in bladder cancer (BLCA) progression remain unclear.
Dongkui Song, Jianjian Yin, Xin Fan, Qi Chang, Yuanheng Dai, Tao Wang, Lei Shi, Linlin Yang, Xiaoming Yang, Tao Liu, Xu Dong Zhang, Lei Jin, Yong-jie Lu, Lirong Zhang   +13 more
openaire   +1 more source

Landscape of N1‐methyladenosin (m1A) modification pattern in colorectal cancer

Cancer Reports, 2023
AbstractBackgroundN1‐methyladenosine (m1A) is a recently identified mRNA modification. However, it is still unclear that how m1A alteration affects the development of colorectal cancer (CRC).AimsThe landscape of m1A modification patterns regarding tumor immune microenvironment (TIME) in CRC is a lack of knowledge.
Chun JIANG, Yuan Tian, Chunjie Xu, Lei GU, Hao Zhang   +4 more
openaire   +3 more sources

Research Progress of RNA Methylation Modification in Colorectal Cancer

Frontiers in Pharmacology, 2022
Accumulating evidence indicates that RNA methylation, as the most common modification of mRNA, is of great significance in tumor progression and metastasis.
Weizheng Liang, Hongyang Yi, Chenyu Mao, Qingxue Meng, Xueliang Wu, Shanliang Li, Jun Xue   +6 more
doaj   +1 more source

Establishment of a N1-methyladenosine-related risk signature for breast carcinoma by bioinformatics analysis and experimental validation

Breast Cancer, 2023
AbstractObjectivesBreast carcinoma (BRCA) has resulted in a huge health burden globally. N1-methyladenosine (m1A) RNA methylation has been proven to play key roles in tumorigenesis. Nevertheless, the function of m1A RNA methylation-related genes in BRCA is indistinct.MethodsThe RNA sequencing (RNA-seq), copy-number variation (CNV), single-nucleotide ...
Leilei Li, Wenhui Yang, Daqi Jia, Shiqi Zheng, Yuzhe Gao, Guanghui Wang   +5 more
openaire   +2 more sources

Selektive Charakterisierung von N1-Methyladenosin neben N7-Methylguanosin im Harn [PDF]

cclm, 1981
We describe the selective analysis of N-methylated ribonucleosides, i.e., N1-methyl adenosine (m1Ado) and N7-methyl guanosine (m7Guo) in the presence of other nucleosides in urine. m1Ado as well as m7Guo were characterized by use of chromatographic techniques including substance specific chemical reactions.
Schlimme, E., Boos, K.-S., Weise, M.
openaire   +1 more source

ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17

Acta Pharmaceutica Sinica B, 2023
Pulmonary hypertension (PH) is an extremely malignant pulmonary vascular disease of unknown etiology. ADAR1 is an RNA editing enzyme that converts adenosine in RNA to inosine, thereby affecting RNA expression. However, the role of ADAR1 in PH development remains unclear.
Junting Zhang, Yiying Li, Jianchao Zhang, Lu Liu, Yuan Chen, Xusheng Yang, Xueyi Liao, Muhua He, Zihui Jia, Jun Fan, Jin-Song Bian, Xiaowei Nie   +11 more
openaire   +3 more sources

M1ARegpred: Epitranscriptome Target Prediction of N1-methyladenosine (m1A) Regulators Based on Sequencing Features and Genomic Features

Frontiers in Bioscience-Landmark, 2022
Background: N1-methyladenosine (m1A) is a reversible post-transcriptional modification in mRNA, which has been proved to play critical roles in various biological processes through interaction with different m1A regulators. There are several m1A regulators existing in the human genome, including YTHDF1-3 and YTHDC1.
Jia-Hui Yao, Meng-Xian Lin, Wen-Jun Liao, Wei-Jie Fan, Xiao-Xin Xu, Haoran Shi, Shu-Xiang Wu   +6 more
openaire   +3 more sources

RNA modification landscape of the human mitochondrial tRNALys regulates protein synthesis

Nature Communications, 2018
Mutations in mitochondrially-encoded tRNA genes can lead to mitochondrial disorders. Here the authors use next generation RNA sequencing to reveal the role of a N1 -methyladenosine modification in tRNALys MERR patients for translation elongation and the ...
Uwe Richter, Molly E. Evans, Wesley C. Clark, Paula Marttinen, Eric A. Shoubridge, Anu Suomalainen, Anna Wredenberg, Anna Wedell, Tao Pan, Brendan J. Battersby   +9 more
doaj   +1 more source

N1‐Methyladenosine‐Related lncRNAs Are Potential Biomarkers for Predicting Prognosis and Immune Response in Uterine Corpus Endometrial Carcinoma

Oxidative Medicine and Cellular Longevity, 2022
Uterine corpus endometrial carcinoma (UCEC) is a malignant disease that, at present, has no well‐characterised prognostic biomarker. In this study, two clusters were identified based on 28 N1‐methyladenosine‐ (m1A‐) related long noncoding RNAs (lncRNAs), of which cluster 1 was related to immune pathways according to the results of an enrichment ...
Jinhui Liu, Rui Geng, Zihang Zhong, Yixin Zhang, Senmiao Ni, Wen Liu, Mulong Du, Jianling Bai   +7 more
openaire   +2 more sources

N1-methyladenosine modification in cancer biology: Current status and future perspectives

Computational and Structural Biotechnology Journal, 2022
Post-transcriptional modifications in RNAs regulate their biological behaviors and functions. N1-methyladenosine (m1A), which is dynamically regulated by writers, erasers and readers, has been found as a reversible modification in tRNA, mRNA, rRNA and ...
Jiexin Li, Haisheng Zhang, Hongsheng Wang   +2 more
doaj   +1 more source