Results 51 to 60 of about 237 (128)

ALKBH3 is dispensable in maintaining hematopoietic stem cells but forced ALKBH3 rectified the differentiation skewing of aged hematopoietic stem cells

Blood Science, 2020
. ALKBH3, a demethylase responsible for demethylating N1-methyladenosine (m1A) in mRNA and N1-methyldeoxyadenosine in single-stranded DNA, plays an important role in DNA repair and cancer cell proliferation.
Hanqing He, Yuqian Wang, Jianwei Wang
doaj   +1 more source

RNA Modifications in Gastrointestinal Cancer: Current Status and Future Perspectives

Biomedicines, 2022
Gastrointestinal (GI) cancer, referring to cancers of the digestive system such as colorectal cancer (CRC), gastric cancer (GC), and liver cancer, is a major cause of cancer-related deaths in the world.
Xiaoting Zhang, Hao Su, Hongyan Chen, Qing Li, Xiaodong Liu, Lin Zhang, William Ka Kei Wu, Matthew Tak Vai Chan, Huarong Chen   +8 more
doaj   +1 more source

Epitranscriptomic Regulation of Bone Metabolism: Emerging Roles of N6‐Methyladenosine (m6A) Modification in Skeletal Homeostasis

Oral Science International, Volume 23, Issue 3, September 2026.
ABSTRACT N6‐methyladenosine (m6A) is the most abundant internal chemical modification of eukaryotic RNA and a central mechanism of epitranscriptomic gene regulation. Although m6A was first characterized in messenger RNA (mRNA), it is also deposited on ribosomal RNA (rRNA), circular RNA, and other RNA species, where it regulates RNA stability, decay ...
Shoichiro Kokabu, Quan Yuan
wiley   +1 more source

Integrative analysis of bulk and single-cell RNA sequencing data reveals distinct subtypes of MAFLD based on N1-methyladenosine regulator expression

Liver Research, 2023
Metabolic dysfunction-associated fatty liver disease (MAFLD) is now the most prevalent chronic liver disease worldwide, with an increasing incidence rate. MAFLD is a heterogeneous disease that can have a low or high-risk profile for developing severe liver disease in its natural course.
Jinyong He, Cuicui Xiao, Cuiping Li, Fan Yang, Cong Du   +4 more
openaire   +3 more sources

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science
N1‐methyladenosine (m1A) modification widely occurs in various RNAs, yet its pathophysiological function in tumorigenesis remains poorly understood. Notably, the expression and biological roles of tRNA m1A methyltransferase 6 noncatalytic subunit (TRMT6)
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
doaj   +1 more source

Contrasting effects of different molecular crowding environments on base‐pair opening/closing dynamics of DNA triplex structures

The FEBS Journal, Volume 293, Issue 16, Page 5067-5083, August 2026.
Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto, Yudai Yamaoki, Takashi Nagata, Masato Katahira   +3 more
wiley   +1 more source

Eine Universelle Nukleosid‐zu‐Nukleosid‐5′‐triphosphat‐Enzymkaskade angetrieben durch Polyphosphat

Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.
Nukleosid‐5′‐Triphosphate (NTPs) sind wichtige Bausteine für Nukleinsäuren. Ihre chemische Synthese ist aufgrund der geringen Ausbeute der 5′‐Triphosphorylierungsreaktion nur wenig effizient. Wir stellen hier eine universelle, durch Polyphosphat angetriebene Zwei‐Enzym‐Kaskade vor, die eine direkte Phosphorylierung von Nukleosiden zu NTPs ermöglicht ...
Jonathan P. Suess, Nicolas V. Cornelissen   +1 more
wiley   +1 more source

The role of RNA modifications in hepatocellular carcinoma: functional mechanism and potential applications

Frontiers in Immunology
Hepatocellular carcinoma (HCC) is a highly aggressive cancer with a poor prognosis. The molecular mechanisms underlying its development remain unclear.
Jin-Xiu Liu, Xiaoping Zhang, Wen-Hua Xu, Xiao-Dan Hao   +3 more
doaj   +1 more source

Multilayer Proteome and Metabolome‐Based Validation Uncovers Combined Regulatory Roles and Predictive Values of 6 RNA Modifications and Cellular Senescence in Alzheimer's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
This study integrated multi‐omics data to analyze the synergistic effects of cellular senescence and RNA modifications on AD pathology. Transcriptome and proteome data were used to validate the stability of machine learning‐screened proteins and the model, while metabolomics data further revealed metabolic alterations during the progression of AD ...
Mengjie Tian, Ke Ye, Xinyi Chen, Lulu Liu, Xinyu Han, Tianhu Zheng, Xu Gao, Qing Xia, Fuyuan Li, Dayong Wang   +9 more
wiley   +1 more source

NaP‐TRAP: A Versatile and Accessible Workflow to Dissect Principles of Translational Regulation and mRNA Stability

Current Protocols, Volume 6, Issue 7, July 2026.
Abstract The translation of messenger RNA (mRNA) into protein is tightly regulated by both cellular trans‐factors and cis‐regulatory elements encoded within transcripts. Although transcript fate can be measured by transcript abundance or translation efficiency, separating the contribution of individual cis‐element within a single transcript is an ...
Amit Gupta, Anna Z. Struba, Srihari Madhavan, Ethan Strayer, Jean‐Denis Beaudoin   +4 more
wiley   +1 more source