Results 51 to 60 of about 4,267 (193)

M1ARegpred: Epitranscriptome Target Prediction of N1-methyladenosine (m1A) Regulators Based on Sequencing Features and Genomic Features

Frontiers in Bioscience-Landmark, 2022
Background: N1-methyladenosine (m1A) is a reversible post-transcriptional modification in mRNA, which has been proved to play critical roles in various biological processes through interaction with different m1A regulators. There are several m1A regulators existing in the human genome, including YTHDF1-3 and YTHDC1.
Jia-Hui Yao, Meng-Xian Lin, Wen-Jun Liao, Wei-Jie Fan, Xiao-Xin Xu, Haoran Shi, Shu-Xiang Wu   +6 more
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Deciphering the epitranscriptome: a green perspective [PDF]

, 2016
The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation - the epitranscriptome.
Burgess, A., David, R., Searle, I.
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The blood metabolome of incident kidney cancer:A case-control study nested within the MetKid consortium [PDF]

, 2021
Background: Excess bodyweight and related metabolic perturbations have been implicated in kidney cancer aetiology, but the specific molecular mechanisms underlying these relationships are poorly understood. In this study we sought to identify circulating
Bull, Caroline J, Corbin, Laura J, Guida, Florence, Johansson, Mattias, Tan, Y, Timpson, Nicholas John, Vincent, Emma E   +6 more
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多細胞生物におけるrRNAのm1A修飾に関する研究 [PDF]

, 2018
この博士論文は内容の要約のみの公開（または一部非公開）になっています筑波大学 (University of Tsukuba ...
YOKOYAMA Wataru, 横山 航
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Diverse cell stresses induce unique patterns of tRNA up- and down-regulation: tRNA-seq for quantifying changes in tRNA copy number [PDF]

, 2014
Emerging evidence points to roles for tRNA modifications and tRNA abundance in cellular stress responses. While isolated instances of stress-induced tRNA degradation have been reported, we sought to assess the effects of stress on tRNA levels at a ...
Abo, Ryan, Dedon, Peter C., Levine, Stuart S., Pang, Yan Ling Joy   +3 more
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A lexicon of DNA modifications: their roles in embryo development and the germline [PDF]

, 2018
5-methylcytosine (5mC) on CpG dinucleotides has been viewed as the major epigenetic modification in eukaryotes for a long time. Apart from 5mC, additional DNA modifications have been discovered in eukaryotic genomes.
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A Common Class of Transcripts with 5\u27-Intron Depletion, Distinct Early Coding Sequence Features, and N1-Methyladenosine Modification [preprint] [PDF]

, 2016
Introns are found in 5\u27 untranslated regions (5\u27UTRs) for 35% of all human transcripts. These 5\u27UTR introns are not randomly distributed: genes that encode secreted, membrane-bound and mitochondrial proteins are less likely to have them ...
Akef, Abdalla, Cenik, Can, Chua, Hon Nian, Moore, Melissa J., Palazzo, Alexander F., Roth, Frederick P., Singh, Guramrit, Snyder, Michael P.   +7 more
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Genetic Regulation of N6-Methyladenosine-RNA in Mammalian Gametogenesis and Embryonic Development [PDF]

, 2022
Emerging evidence shows that m(6)A is the most abundant modification in eukaryotic RNA molecules. It has only recently been found that this epigenetic modification plays an important role in many physiological and pathological processes, such as cell ...
Cao, Hongguo, Cao, Zhikun, Chang, Yuguang, Felici, Massimo De, Feng, Yanqin, Ge, Wei, Muhammad, Zafir, Shen, Wei, Wang, Jing, Yan, Zihui, Yi, Mingliang, Zhang, Zijun, Zhou, Tingting   +12 more
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The N¹-Methyladenosine Methylome of Petunia mRNA [PDF]

Plant Physiology, 2020
N1-methyladenosine is a unique type of base methylation in that it blocks Watson-Crick base pairing and introduces a positive charge. m1A is prevalent in yeast and mammalian mRNA and plays a functional role. However, little is known about the abundance, dynamics, and topology of this modification in plant mRNA.
Weiyuan Yang, Jie Meng, Juanxu Liu, Beibei Ding, Tao Tan, Qian Wei, Yixun Yu   +6 more
openaire   +2 more sources

Reduced uremic metabolites are prominent feature of sarcopenia, distinct from antioxidative markers for frailty [PDF]

, 2021
Due to global aging, frailty and sarcopenia are increasing. Sarcopenia is defined as loss of volume and strength of skeletal muscle in elderlies, while frailty involves multiple domains of aging-related dysfunction, impaired cognition, hypomobility, and ...
Kameda, Masahiro, Kondoh, Hiroshi, Teruya, Takayuki, Yanagida, Mitsuhiro   +3 more
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