Results 71 to 80 of about 3,755 (152)

The biological function of demethylase ALKBH1 and its role in human diseases

Heliyon
AlkB homolog 1 (ALKBH1) is a member of the AlkB family of dioxygenases that are dependent on Fe(II) and α-ketoglutarate. Mounting evidence demonstrates that ALKBH1 exhibits enzymatic activity against various substrates, including N6-methyladenosine (m6A),
Jing Zhong, Zhengyang Xu, Ning Ding, Yanting Wang, Wenwen Chen   +4 more
doaj   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Molecular Subtype Identification and Prognostic Prediction of Pancreatic Cancer Based on m6A/m5C/m1A‐Related Genes

Journal of Cellular and Molecular Medicine, Volume 30, Issue 12, June 2026.
ABSTRACT Pancreatic cancer, characterized by an unfavourable prognosis, necessitates early diagnosis and prompt therapeutic intervention. This study aimed to delineate the functional implications of m6A/m1A/m5C‐related genes in pancreatic carcinogenesis and establish a prognostic model.
Yunyang Wang, Xueqing Hong, Dingge Cao, Mingzhen Wang, Abulaihaiti Tuergong, Hongrui Liu, Yuxuan Guo, Xia Ting, Xujun Liu, Xiao Huo, Wenzhe Si   +10 more
wiley   +1 more source

The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value

Frontiers in Immunology
Glioma represents a highly lethal form of malignant tumour, with RNA methylation emerging as a critical regulator of its oncogenesis and progression.
Shao-Ze Zhang, Shao-Ze Zhang, Shao-Ze Zhang, Shao-Yan Liu, Meng-Die Cheng, Yin-Feng Zhang, Jia-Wei Tian   +6 more
doaj   +1 more source

Development and validation of monoclonal antibodies against N6-methyladenosine for the detection of RNA modifications.

PLoS ONE, 2019
RNA contains various chemical modifications, among which N6-methyladenosine (m6A) is the most prevalent modified nucleotide in eukaryotic mRNA. Emerging evidence suggests that m6A plays an important role in regulating a variety of cellular functions by ...
Shun Matsuzawa, Yuka Wakata, Fumiya Ebi, Masaharu Isobe, Nobuyuki Kurosawa   +4 more
doaj   +1 more source

METTL3/YTHDF1‐Driven SURF6 Promotes Prostate Cancer Stemness via CDK4

Journal of Cellular and Molecular Medicine, Volume 30, Issue 12, June 2026.
ABSTRACT Prostate cancer (PCa) remains a major health challenge globally, necessitating the identification of novel therapeutic targets to improve patient outcomes. This study investigates the role of the SURF6 gene in PCa, focusing on its expression patterns, molecular mechanisms, and biological behaviours in vitro and in vivo.
Yue Cheng, Min Zhang, Danfang Shi, XuFen Xia   +3 more
wiley   +1 more source

RNA Modifications in Pathogenic Viruses: Existence, Mechanism, and Impacts

Microorganisms
RNA modification is a key posttranscriptional process playing various biological roles, and one which has been reported to exist extensively in cellular RNAs.
Yingying Zou, Zhoule Guo, Xing-Yi Ge, Ye Qiu   +3 more
doaj   +1 more source

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

Advanced Science, Volume 13, Issue 29, 22 May 2026.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li, Xiangmin Tan, Yaran Liu, Yongquan He, Bo Yuan, Ping Wang, Guangzhi Ma, Mengzhe Guo, Jian Zhou, Qiang Sun   +9 more
wiley   +1 more source

Mechanisms and therapeutic potential of YTHDF readers: Linking epitranscriptomics to cancer

Journal of Pharmaceutical Analysis
YT521-B homology domain-containing family paralogs (YTHDFs), as RNA epigenetic modification effector proteins, fully or partially participate in N6-methyladenosine (m6A), N1-methyladenosine (m1A), and 5-methylcytosine (m5C) modifications, which play ...
Na Deng, Qiang Sun, Shuying Wang, Shiheng Jia, Chen Zheng, Fanglin Wang, Shuang Ma, Heng Zhou, Weiwei Liu   +8 more
doaj   +1 more source

Dynamic N¹-Methyladenosine in Plant Messenger RNA [PDF]

Plant Physiology, 2020
Deposition of different chemical groups onto RNA generates diverse RNA modifications. All types of prokaryotic and eukaryotic RNA can undergo modifications. For example, methylation of the adenosine bases at the nitrogen-6 or nitrogen-1 position generates N6-methyladenosine (m6A) and N1-
openaire   +2 more sources