Results 71 to 80 of about 237 (128)

Identification of Novel Small‐Molecule Inhibitors Targeting KDM5B and Evaluation of Their Antitumour Effects

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT KDM5B, a member of the KDM5 family of histone demethylases, plays a critical role in transcriptional repression by demethylating H3K4me2/3. It regulates key biological processes such as development, stem cell maintenance, and oncogenesis, and its aberrant expression is implicated in various cancers. Accordingly, KDM5B is considered a promising
Tomoaki Hara, Sikun Meng, Masamitsu Konno, Naohiro Nishida, Jun Koseki, Kanji Meguro, Yasuhiko Kawano, Toshiya Morie, Shingo Dan, Taroh Satoh, Shuji Akai, Kazutake Tsujikawa, Hidetoshi Eguchi, Masaki Mori, Yutaka Miura, Nobuhiro Nishiyama, Hideshi Ishii   +16 more
wiley   +1 more source

RNA Modifications in Pathogenic Viruses: Existence, Mechanism, and Impacts

Microorganisms
RNA modification is a key posttranscriptional process playing various biological roles, and one which has been reported to exist extensively in cellular RNAs.
Yingying Zou, Zhoule Guo, Xing-Yi Ge, Ye Qiu   +3 more
doaj   +1 more source

TRMT10C promotes mitochondrial fission through transferrin receptor m1A methylation modification and aggravates the progression of atrial fibrillation

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
TRMT10C promotes mitochondrial dynamics imbalance (excessive fission) by regulating TFRC m1A methylation modification, induces myocardial fibrosis, and exacerbates the progression of AF. Abstract Atrial fibrillation (AF) is a common cardiac arrhythmia often accompanied by structural remodeling of the atria, particularly fibrosis, and disruption of ...
Nijina Li, Hao Zhang
wiley   +1 more source

RNA methylation in cell death: mechanisms and clinical applications

Molecular Cancer
RNA methylation represents a critical epi-transcriptomic modification that regulates cell fate by modulating diverse aspects of RNA metabolism, including splicing, export, translation, and degradation.
Shuang Shang, Xianzhao Wang, Xin Xu, Yiwen Huang, Daolin Tang, Jiayi Wang, Lifang Ma   +6 more
doaj   +1 more source

The metabolites for muscle and osteoclast activity are indicators of femoral neck osteoporosis

Scientific Reports
Femoral neck osteoporosis is a critical risk factor for a bedbound state, which significantly decreases overall life expectancy, if a patient falls and suffers a fracture.
Masahiro Kameda, Mitsuhiro Yanagida, Hiroshi Kondoh   +2 more
doaj   +1 more source

Mechanisms and therapeutic potential of YTHDF readers: Linking epitranscriptomics to cancer

Journal of Pharmaceutical Analysis
YT521-B homology domain-containing family paralogs (YTHDFs), as RNA epigenetic modification effector proteins, fully or partially participate in N6-methyladenosine (m6A), N1-methyladenosine (m1A), and 5-methylcytosine (m5C) modifications, which play ...
Na Deng, Qiang Sun, Shuying Wang, Shiheng Jia, Chen Zheng, Fanglin Wang, Shuang Ma, Heng Zhou, Weiwei Liu   +8 more
doaj   +1 more source

RNA modifications and their role in gene expression

Frontiers in Molecular Biosciences
Post-transcriptional RNA modifications have recently emerged as critical regulators of gene expression programs. Understanding normal tissue development and disease susceptibility requires knowledge of the various cellular mechanisms which control gene ...
I. Made Artika, Rini Arianti, Rini Arianti, Máté Á. Demény, Endre Kristóf   +4 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Involvement of N1-Methyladenosine (m1A) in the mitochondrial ND5 mRNA and the corresponding writer enzyme TRMT10C in Alzheimer's disease

, 2023
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common form of dementia. Even though the U.S. Food and Drug Administration (FDA) this year approved a new antibody that may moderately decelerate cognitive decline, there is still no treatment that can halt or even reverse the symptoms of AD. Apart from the prime suspects (
openaire   +3 more sources

Adapting nanopore sequencing basecalling models for modification detection via incremental learning and anomaly detection

Nature Communications
We leverage machine learning approaches to adapt nanopore sequencing basecallers for nucleotide modification detection. We first apply the incremental learning (IL) technique to improve the basecalling of modification-rich sequences, which are usually of
Ziyuan Wang, Yinshan Fang, Ziyang Liu, Ning Hao, Hao Helen Zhang, Xiaoxiao Sun, Jianwen Que, Hongxu Ding   +7 more
doaj   +1 more source