Results 81 to 90 of about 3,755 (152)

RNA modifications and their role in gene expression

Frontiers in Molecular Biosciences
Post-transcriptional RNA modifications have recently emerged as critical regulators of gene expression programs. Understanding normal tissue development and disease susceptibility requires knowledge of the various cellular mechanisms which control gene ...
I. Made Artika, Rini Arianti, Rini Arianti, Máté Á. Demény, Endre Kristóf   +4 more
doaj   +1 more source

Adapting nanopore sequencing basecalling models for modification detection via incremental learning and anomaly detection

Nature Communications
We leverage machine learning approaches to adapt nanopore sequencing basecallers for nucleotide modification detection. We first apply the incremental learning (IL) technique to improve the basecalling of modification-rich sequences, which are usually of
Ziyuan Wang, Yinshan Fang, Ziyang Liu, Ning Hao, Hao Helen Zhang, Xiaoxiao Sun, Jianwen Que, Hongxu Ding   +7 more
doaj   +1 more source

Involvement of N1-Methyladenosine (m1A) in the mitochondrial ND5 mRNA and the corresponding writer enzyme TRMT10C in Alzheimer's disease

, 2023
Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common form of dementia. Even though the U.S. Food and Drug Administration (FDA) this year approved a new antibody that may moderately decelerate cognitive decline, there is still no treatment that can halt or even reverse the symptoms of AD. Apart from the prime suspects (
openaire   +3 more sources

Abundant mRNA m1A modification in dinoflagellates: a new layer of gene regulation

EMBO Reports
Dinoflagellates, a class of unicellular eukaryotic phytoplankton, exhibit minimal transcriptional regulation, representing a unique model for exploring gene expression.
Chongping Li, Ying Li, Jia Guo, Yuci Wang, Xiaoyan Shi, Yangyi Zhang, Nan Liang, Honghui Ma, Jie Yuan, Jiawei Xu, Hao Chen   +10 more
doaj   +1 more source

The regulatory role of N1-methyladenosine in tRNA in the development of urothelial carcinoma of the bladder

, 2023
Urothelial carcinoma of the bladder (BLCA) is a disease of high occurrence globally. A high recurrence frequency often necessitates lifelong control schemes of invasive examinations and harsh treatment, reducing the life quality of patients. Several RNA-modifying proteins have been associated with BLCA, and a link between transfer RNA (tRNA ...
openaire   +2 more sources

The functions and mechanisms of RNA modification in prostate: Current status and future perspectives

Frontiers in Genetics
The increasing incidence and mortality of prostate cancer worldwide significantly impact the life span of male patients, emphasizing the urgency of understanding its pathogenic mechanism and associated molecular changes that regulate tumor progression ...
Zhijin Zhang, Zhijin Zhang, Ji Liu, Ji Liu, Yang Wu, Zhuoran Gu, Zhuoran Gu, Libin Zou, Libin Zou, Yingdi Liu, Jiang Geng, Jiang Geng, Shiyu Mao, Shiyu Mao, Ming Luo, Ming Luo, Changcheng Guo, Changcheng Guo, Wentao Zhang, Wentao Zhang, Xudong Yao, Xudong Yao   +21 more
doaj   +1 more source

N1-methyladenosine formation, gene regulation, biological functions, and clinical relevance

Molecular Therapy, 2023
Weidong Xiong, Yongchao Zhao, Zilun Wei, Chaofu Li, Ranzun Zhao, Junbo Ge, Bei Shi   +6 more
openaire   +1 more source

Advances in research on RNA methylation and cancer radiotherapy resistance

Frontiers in Oncology
RNA methylation is a type of reversible chemical modification in epitranscriptomics that influences gene expression by dynamically regulating RNA functions.
Hui Liu, Hui Luo, Ming Jin, Zhen Zheng, Yang Xi, Kaitai Liu   +5 more
doaj   +1 more source

Studies on N1-Methyladenosine Modification of rRNA in Multicellular Organisms

Studies on N1-Methyladenosine Modification of rRNA in Multicellular Organisms
2017 【要旨】
openaire   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source