Results 61 to 70 of about 4,267 (193)
Emerging roles of RNA methylation in gastrointestinal cancers
Cancer Cell International, 2020 RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression ...
Shanshan Xie +8 more
doaj +1 more source
The potential regulatory role of RNA methylation in ovarian cancer
RNA Biology, 2023 Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao +5 more
doaj +1 more source
Alkyltransferase Ribozyme for Site‐Specific N4‐Cytidine Alkylation
Angewandte Chemie, Volume 138, Issue 20, 11 May 2026.CSAR is the first ribozyme that catalyzes direct alkylation of an exocyclic amino group of an RNA nucleobase. The ribozyme was isolated as a self‐labeling catalyst from an in vitro selection library and engineered into a trans‐active ribozyme that catalyzes the transfer of a benzyl group from an O6‐modifed guanine to the N4 amino group of a specific ...
Evgeniia Dorinova +2 more
wiley +2 more sources
The landscape of N1-methyladenosine (m1A) modification in mRNA of the decidua in severe preeclampsia. [PDF]
Biomol BiomedRecent discoveries in mRNA modification have highlighted N1-methyladenosine (m1A), but its role in preeclampsia (PE) pathogenesis remains unclear. In this study, we utilized methylated RNA immunoprecipitation sequencing (MeRIP-seq) and RNA sequencing (RNA-seq) to identify m1A peaks and the expression profile of mRNA in the decidua of humans with early ...
Tong J, Li H, Zhang L, Zhang C.
europepmc +4 more sources
Mapping epigenetic modifications by sequencing technologies [PDF]
, 2023 The “epigenetics” concept was first described in 1942. Thus far, chemical modifications on histones, DNA, and RNA have emerged as three important building blocks of epigenetic modifications. Many epigenetic modifications have been intensively studied and
Chen, Xiufei +3 more
core +2 more sources
Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma
Frontiers in Pharmacology, 2021 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood.
Xing-xing Huo +10 more
doaj +1 more source
Research advances of mRNA methylation in kidney diseases
Linchuang shenzangbing zazhiRecently mRNA methylation modification has been extensively examined, including N6-methyladenosine (m6A), N5-methylcytidine (m5C) and N1-methyladenosine (m1A).
Shi-wen Zhang, Jun-jun Luan, Hua Zhou
doaj +1 more source
The role of RNA modification in hepatocellular carcinoma
Frontiers in Pharmacology, 2022 Hepatocellular carcinoma (HCC) is a highly mortal type of primary liver cancer. Abnormal epigenetic modifications are present in HCC, and RNA modification is dynamic and reversible and is a key post-transcriptional regulator.
Qiang Feng +7 more
doaj +1 more source
Insights into the regulatory role of RNA methylation modifications in glioma
Journal of Translational Medicine, 2023 Epitranscriptomic abnormalities, which are highly prevalent in primary central nervous system malignancies, have been identified as crucial contributors to the development and progression of gliomas.
Shengrong Long +12 more
doaj +1 more source
Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers
Molecular Therapy: Nucleic Acids, 2021 As next-generation sequencing (NGS) is leaping forward, more than 160 covalent RNA modification processes have been reported, and they are widely present in every organism and overall RNA type.
Dawei Rong +11 more
doaj +1 more source