RNA modifications and cancer ferroptosis [PDF]
Cancer Cell InternationalIn recent years, cancer treatment has faced significant challenges, highlighting the urgent need for novel therapeutic strategies. Ferroptosis is a regulated type of cellular demise that is distinguished by lipid peroxidation reliant on iron.
Yingda Xie +8 more
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Direct detection of RNA modifications and structure using single-molecule nanopore sequencing
Cell Genomics, 2022 Summary: Modifications are present on many classes of RNA, including tRNA, rRNA, and mRNA. These modifications modulate diverse biological processes such as genetic recoding and mRNA export and folding. In addition, modifications can be introduced to RNA
William Stephenson +5 more
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RNA modifications in cancer [PDF]
MedCommRNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such as N6‐methyladenosine (m6A) and 5‐methylcytosine (m5C), are implicated in various cellular processes.
Han Wu +11 more
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RNA Modifications in Health and Disease [PDF]
MedCommRNA modifications, including N6‐methyladenosine (m6A), 5‐methylcytosine, and pseudouridine, serve as pivotal regulators of gene expression with significant implications for human health and disease.
Shiqi Li +5 more
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Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing [PDF]
Advanced GeneticsRNA modifications add a dynamic and versatile regulatory layer to gene expression, influencing RNA stability, splicing, translation, and cellular responses.
Yaran Liu, Yang Li, Qiang Sun
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Mitochondria at the intersections of RNA modifications and metabolism reprogramming implications in cell death, tumor microenvironment, and immunotherapy [PDF]
Journal of Hematology & OncologyMitochondria, the powerhouse of the cell, orchestrate a plethora of critical functions, including energy production, metabolic regulation, programmed cell death, and signal transduction.
Jiaxun Zhang +11 more
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Hydroxychloroquine Modulates m6A RNA Methylation in Prostate Cancer Cells
Cumhuriyet Science Journal, 2023 Prostate cancer ranks as the second most prevalent cancer in men globally. One of the evolving subjects of investigation in prostate cancer is the role of N6-methyladenosine (m6A) modifications. Hydroxychloroquine (HCQ), an autophagy inhibitor, was shown
Merve Gülsen Bal Albayrak, Sevinc Yanar
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Unravelling Strain-Specific Modifications of Toxoplasma gondii tRNA and sncRNA Using LC-MS/MS
Microbiology Spectrum, 2023 Many RNA modifications have been detected in rRNA, tRNA and small noncoding RNA (sncRNA) as well as in low-abundance RNA species such mRNA. Although RNA modifications play roles in many cellular and biological processes in various domains of life ...
Wei Wang +8 more
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Roles of RNA Modifications in Diverse Cellular Functions
Frontiers in Cell and Developmental Biology, 2022 Chemical modifications of RNA molecules regulate both RNA metabolism and fate. The deposition and function of these modifications are mediated by the actions of writer, reader, and eraser proteins.
Emma Wilkinson +4 more
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An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization
Cells, 2019 Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast +2 more
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