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RNA modifications in cancer [PDF]
MedCommRNA modifications are emerging as critical cancer regulators that influence tumorigenesis and progression. Key modifications, such as N6‐methyladenosine (m6A) and 5‐methylcytosine (m5C), are implicated in various cellular processes.
Han Wu +11 more
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RNA modifications and cancer ferroptosis [PDF]
Cancer Cell InternationalIn recent years, cancer treatment has faced significant challenges, highlighting the urgent need for novel therapeutic strategies. Ferroptosis is a regulated type of cellular demise that is distinguished by lipid peroxidation reliant on iron.
Yingda Xie +8 more
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RNA modifications in brain tumorigenesis [PDF]
Acta Neuropathologica Communications, 2020 RNA modifications are emerging as critical regulators in cancer biology, thanks to their ability to influence gene expression and the predominant protein isoforms expressed during cell proliferation, migration, and other pro-oncogenic properties.
Albert Z. Huang +2 more
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RNA Modifications in Health and Disease [PDF]
MedCommRNA modifications, including N6‐methyladenosine (m6A), 5‐methylcytosine, and pseudouridine, serve as pivotal regulators of gene expression with significant implications for human health and disease.
Shiqi Li +5 more
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Advances in Detecting RNA Modifications Using Direct RNA Nanopore Sequencing [PDF]
Advanced GeneticsRNA modifications add a dynamic and versatile regulatory layer to gene expression, influencing RNA stability, splicing, translation, and cellular responses.
Yaran Liu, Yang Li, Qiang Sun
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Hydroxychloroquine Modulates m6A RNA Methylation in Prostate Cancer Cells
Cumhuriyet Science Journal, 2023 Prostate cancer ranks as the second most prevalent cancer in men globally. One of the evolving subjects of investigation in prostate cancer is the role of N6-methyladenosine (m6A) modifications. Hydroxychloroquine (HCQ), an autophagy inhibitor, was shown
Merve Gülsen Bal Albayrak, Sevinc Yanar
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Unravelling Strain-Specific Modifications of Toxoplasma gondii tRNA and sncRNA Using LC-MS/MS
Microbiology Spectrum, 2023 Many RNA modifications have been detected in rRNA, tRNA and small noncoding RNA (sncRNA) as well as in low-abundance RNA species such mRNA. Although RNA modifications play roles in many cellular and biological processes in various domains of life ...
Wei Wang +8 more
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Roles of RNA Modifications in Diverse Cellular Functions
Frontiers in Cell and Developmental Biology, 2022 Chemical modifications of RNA molecules regulate both RNA metabolism and fate. The deposition and function of these modifications are mediated by the actions of writer, reader, and eraser proteins.
Emma Wilkinson +4 more
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An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization
Cells, 2019 Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide.
Reginald V.C.T. van der Kwast +2 more
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RNA modifications detection by comparative Nanopore direct RNA sequencing
Nature Communications, 2021 Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data.
Adrien Leger +18 more
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