Results 41 to 50 of about 3,540,807 (288)
Chemical Modifications of Ribosomal RNA
, 2022 AbstractCellular RNAs in all three kingdoms of life are modified with diverse chemical modifications. These chemical modifications expand the topological repertoire of RNAs, and fine-tune their functions. Ribosomal RNA in yeast contains more than 100 chemically modified residues in the functionally crucial and evolutionary conserved regions.
Sunny, Sharma, Karl-Dieter, Entian
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Understanding RNA modifications: the promises and technological bottlenecks of the ‘epitranscriptome’ [PDF]
Open Biology, 2017 The discovery of mechanisms that alter genetic information via RNA editing or introducing covalent RNA modifications points towards a complexity in gene expression that challenges long-standing concepts.
Matthias Schaefer +2 more
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Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis
Frontiers in Genetics, 2022 As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate.
Hui-Ming Chen +9 more
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RNA modifications modulate gene expression during development
Science, 2018 RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programs. They affect diverse eukaryotic biological processes, and the correct deposition of many of these modifications is required for normal ...
M. Frye +3 more
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Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine
Signal Transduction and Targeted Therapy, 2022 Cancer is one of the major diseases threatening human life and health worldwide. Epigenetic modification refers to heritable changes in the genetic material without any changes in the nucleic acid sequence and results in heritable phenotypic changes ...
Chen Xue +7 more
semanticscholar +1 more source
Regulatory RNAs: role as scaffolds assembling protein complexes and their epigenetic deregulation
Exploration of Targeted Anti-tumor TherapyRecently, new data have been added to the interaction between non-coding RNAs (ncRNAs) and epigenetic machinery. Epigenetics includes enzymes involved in DNA methylation, histone modifications, and RNA modifications, and mechanisms underlying chromatin ...
Palmiro Poltronieri
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RNA modifications in mammals: from basic research to biotechnological application [PDF]
ExRNARNA, a crucial molecule in protein synthesis and gene expression regulation, plays an essential role in organisms. RNA modifications, acting as epigenetic marks, subtly adjust the structure, stability, and function of RNA, thereby regulating gene ...
Yihang Li +3 more
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Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma
Frontiers in Pharmacology, 2021 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood.
Xing-xing Huo +10 more
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PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications
Nature Cell Biology, 2021 Although high-throughput RNA sequencing (RNA-seq) has greatly advanced small non-coding RNA (sncRNA) discovery, the currently widely used complementary DNA library construction protocol generates biased sequencing results.
Junchao Shi +31 more
semanticscholar +1 more source
RNA Modification in Metabolism
MedCommABSTRACTEpigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and the most prevalent modification in RNA is N6‐methyladenosine (m6A). Recently, RNA modification has emerged as a potential target for disease treatment.
Yadi Liu +4 more
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