Results 51 to 60 of about 3,540,807 (288)
Quantitative Analysis of RNA Modifications [PDF]
, 2010 RNA modifications impact numerous cellular processes such as pre-mRNA splicing and protein synthesis. The elucidation of the mechanisms by which these modifications impact cellular processes necessitates the ability to both detect and quantify the presence of these modifications within RNA molecules.
John, Karijolich +2 more
openaire +2 more sources
De novo basecalling of RNA modifications at single molecule and nucleotide resolution
Genome BiologyRNA modifications influence RNA function and fate, but detecting them in individual molecules remains challenging for most modifications. Here we present a novel methodology to generate training sets and build modification-aware basecalling models. Using
S. Cruciani +5 more
semanticscholar +1 more source
Nature CommunicationsProfiling RNA modifications is essential to understand their functions and interactions. By taking the advantages of nanopore direct RNA sequencing, we present DirectRM, enabling simultaneous detection of six abundant modifications (N4-acetylcytidine, 1 ...
Yu-xin Zhang +10 more
semanticscholar +1 more source
Detection technologies for RNA modifications
Experimental and Molecular Medicine, 2022 To date, more than 170 chemical modifications have been characterized in RNA, providing a new layer of gene expression regulation termed the ‘epitranscriptome’.
Yan Zhang, Liang Lu, Xiaoyu Li
semanticscholar +1 more source
Nanopore-Based Detection of Viral RNA Modifications
mBio, 2022 The chemical modification of ribonucleotides plays an integral role in the biology of diverse viruses and their eukaryotic host cells. Mapping the precise identity, location, and abundance of modified ribonucleotides remains a key goal of many studies ...
Jonathan S. Abebe +2 more
doaj +1 more source
m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Nature Biotechnology, 2022 Functional studies of the RNA N6-methyladenosine (m6A) modification have been limited by an inability to map individual m6A-modified sites in whole transcriptomes.
Lulu Hu +17 more
semanticscholar +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Cup‐like nuclei are a distinctive morphological feature observed in certain cases of acute lymphoblastic leukemia (ALL). We provide evidence that they characterize DUX4/ERG ALL independently of IKZF1 deletion and reveal marked mitochondrial accumulation in this ALL subset.
Chloé Arfeuille +9 more
wiley +1 more source
The emerging role of RNA modifications in the regulation of mRNA stability
Experimental and Molecular Medicine, 2020 Many studies have highlighted the importance of the tight regulation of mRNA stability in the control of gene expression. mRNA stability largely depends on the mRNA nucleotide sequence, which affects the secondary and tertiary structures of the mRNAs ...
Sung Ho Boo, Yoon Ki Kim
semanticscholar +1 more source
The potential regulatory role of RNA methylation in ovarian cancer
RNA Biology, 2023 Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan +1 more
wiley +1 more source