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mRNA Regulation by RNA Modifications
Annual Review of Biochemistry, 2023 Chemical modifications on mRNA represent a critical layer of gene expression regulation. Research in this area has continued to accelerate over the last decade, as more modifications are being characterized with increasing depth and breadth. mRNA modifications have been demonstrated to influence nearly every step from the early phases of transcript ...
Gilbert, Wendy V., Nachtergaele, Sigrid
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Recent Advances in Identification of RNA Modifications [PDF]
, 2016 RNA modifications are involved in a broad spectrum of biological and physiological processes. To reveal the functions of RNA modifications, it is important to accurately predict their positions.
Hao Lin, Wei Chen
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RNA modifications in mammals: from basic research to biotechnological application [PDF]
ExRNARNA, a crucial molecule in protein synthesis and gene expression regulation, plays an essential role in organisms. RNA modifications, acting as epigenetic marks, subtly adjust the structure, stability, and function of RNA, thereby regulating gene ...
Yihang Li +3 more
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Regulatory RNAs: role as scaffolds assembling protein complexes and their epigenetic deregulation
Exploration of Targeted Anti-tumor TherapyRecently, new data have been added to the interaction between non-coding RNAs (ncRNAs) and epigenetic machinery. Epigenetics includes enzymes involved in DNA methylation, histone modifications, and RNA modifications, and mechanisms underlying chromatin ...
Palmiro Poltronieri
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The potential regulatory role of RNA methylation in ovarian cancer
RNA Biology, 2023 Updates in whole genome sequencing technologies have revealed various RNA modifications in cancer, among which RNA methylation is a frequent posttranscriptional modification.
Shijie Zhao +5 more
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RNA Modification in Metabolism
MedCommABSTRACTEpigenetic regulation in disease development has been witnessed within this decade. RNA methylation is the predominant form of epigenetic regulation, and the most prevalent modification in RNA is N6‐methyladenosine (m6A). Recently, RNA modification has emerged as a potential target for disease treatment.
Yadi Liu +4 more
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Quantitative Analysis of RNA Modifications [PDF]
, 2010 RNA modifications impact numerous cellular processes such as pre-mRNA splicing and protein synthesis. The elucidation of the mechanisms by which these modifications impact cellular processes necessitates the ability to both detect and quantify the presence of these modifications within RNA molecules.
John, Karijolich +2 more
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Small RNA Modifications: Integral to Function and Disease [PDF]
, 2016 Small RNAs have the potential to store a secondary layer of labile biological information in the form of modified nucleotides. Emerging evidence has shown that small RNAs including microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs) and tRNA-derived small
Cozen, Aaron E +4 more
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RNA Modifications in Pathogenic Bacteria: Impact on Host Adaptation and Virulence [PDF]
, 2021 RNA modifications are involved in numerous biological processes and are present in all RNA classes. These modifications can be constitutive or modulated in response to adaptive processes.
Laura Antoine +13 more
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Roles of Major RNA Adenosine Modifications in Head and Neck Squamous Cell Carcinoma
Frontiers in Pharmacology, 2021 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer malignancy worldwide and is known to have poor prognosis. The pathogenesis behind the development of HNSCC is not fully understood.
Xing-xing Huo +10 more
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