Results 31 to 40 of about 503,240 (288)
Role of RNA modifications in carcinogenesis and carcinogen damage response [PDF]
, 2022 The field of epitranscriptomics encompasses the study of post-transcriptional RNA modifications and their regulatory enzymes. Among the numerous RNA modifications, N6-methyladenosine (m6A) has been identified as the most common internal modification of ...
Emma Wilkinson +5 more
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RNA modifications as emerging therapeutic targets [PDF]
, 2021 The field of epitranscriptome, posttranscriptional modifications to RNAs, isstill growing up and has presented substantial evidences for the role of RNAmodifications in diseases.
Çayır, Akın
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The RNA modification database [PDF]
Nucleic Acids Research, 1996 The RNA modification database provides a comprehensive listing of posttranscriptionally modified nucleosides from all RNAs, and is maintained as an updated version of the initial printed report [Limbach,P.A., Crain,P.F. and McCloskey,J.A. (1994)Nucleic Acids Res. , 22, 2183-2196].
Pamela F. Crain, James A. McCloskey
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Investigation and Characterization of RNA Modifications [PDF]
, 2021 My thesis focuses on the investigation and characterization of RNA modifications. RNA is post-transcriptionally modified on the nucleoside bases and/or on the ribose-phosphate backbone. RNA modifications are conserved from prokaryotes to eukaryotes. Each
Zhang, Wen
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Detection of RNA modifications [PDF]
RNA Biology, 2010 RNA nucleotide modifications are typically of low abundance and frequently go unnoticed by standard detection methods of molecular biology and cell biology. With a burst of knowledge intruding from such diverse areas as genomics, structural biology, regulation of gene expression and immunology, it becomes increasingly clear that many exciting functions
Stefanie, Kellner +2 more
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ALKBHs-facilitated RNA modifications and de-modifications [PDF]
DNA Repair, 2016 The AlkB gene that protects E.coli against methylation damage to DNA was identified more than 3 decades ago. 20 years later, the AlkB protein was shown to catalyze repair of methylated DNA base lesions by oxidative demethylation. Two human AlkB homologs were characterized with similar DNA repair activities and seven additional human AlkB homologs were ...
Endalkachew, A Alemu +2 more
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Post-Transcriptional Regulation of Viral RNA through Epitranscriptional Modification
Cells, 2021 The field of mRNA modifications has been steadily growing in recent years as technologies have improved and the importance of these residues became clear.
David G. Courtney
doaj +1 more source
RNA modifications can affect RNase H1-mediated PS-ASO activity
Molecular Therapy: Nucleic Acids, 2022 Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1.
Katelyn A. Doxtader Lacy +3 more
doaj +1 more source
Accurate detection of m6A RNA modifications in native RNA sequences [PDF]
, 2019 The epitranscriptomics field has undergone an enormous expansion in the last few years; however, a major limitation is the lack of generic methods to map RNA modifications transcriptome-wide.
Ramirez, Jose Miguel +25 more
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Regulatory roles of RNA modifications in breast cancer [PDF]
, 2021 Collectively referred to as the epitranscriptome, RNA modifications play important roles in gene expression control regulating relevant cellular processes.
Francesca Aguilo +8 more
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