Results 31 to 40 of about 3,540,807 (288)
Post-Transcriptional Regulation of Viral RNA through Epitranscriptional Modification
Cells, 2021 The field of mRNA modifications has been steadily growing in recent years as technologies have improved and the importance of these residues became clear.
David G. Courtney
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RNA modifications: importance in immune cell biology and related diseases
Signal Transduction and Targeted Therapy, 2022 RNA modifications have become hot topics recently. By influencing RNA processes, including generation, transportation, function, and metabolization, they act as critical regulators of cell biology.
L. Cui +9 more
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RNA modifications can affect RNase H1-mediated PS-ASO activity
Molecular Therapy: Nucleic Acids, 2022 Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1.
Katelyn A. Doxtader Lacy +3 more
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The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities
Molecular Cancer, 2021 RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances have been made in understanding the functional role of RNA modifications in regulating coding and non-coding RNA ...
P. Nombela +2 more
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A New Epigenetic Crosstalk: Chemical Modification Information Flow
Advanced Genetics, 2023 Central dogma is the most fundamental hypothesis in the field of molecular biology and explains the genetic information flow from DNA to protein. Beyond residue‐by‐residue transmission of sequential information, chemical modifications of DNA, RNA, and ...
Hongwoo Lee +2 more
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Small RNA modifications: regulatory molecules and potential applications
Journal of Hematology & Oncology, 2023 Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of essential functions within cells.
Qunli Xiong, Yaguang Zhang
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Cellular Dynamics of RNA Modification [PDF]
Accounts of Chemical Research, 2011 Five decades of research have identified more than 100 ribonucleosides that are post-transcriptionally modified. Many modified nucleosides are conserved throughout bacteria, archaea, and eukaryotes, while some are unique to each branch of life. However, the cellular and functional dynamics of RNA modification remain largely unexplored, mostly because ...
Chengqi, Yi, Tao, Pan
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RMBase v3.0: decode the landscape, mechanisms and functions of RNA modifications
Nucleic Acids Research, 2023 Although over 170 chemical modifications have been identified, their prevalence, mechanism and function remain largely unknown. To enable integrated analysis of diverse RNA modification profiles, we have developed RMBase v3.0 (http ...
Jia-Jia Xuan +9 more
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The impact of RNA modifications on the biology of DNA virus infection
European Journal of Cell Biology, 2022 Approximately 170 RNA modifications have been identified and these are critical for determining the fate and function of cellular RNAs. Similar to human transcripts, viral RNAs possess an extensive RNA modification landscape.
Suba Rajendren, John Karijolich
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The role of RNA modification in hepatocellular carcinoma
Frontiers in Pharmacology, 2022 Hepatocellular carcinoma (HCC) is a highly mortal type of primary liver cancer. Abnormal epigenetic modifications are present in HCC, and RNA modification is dynamic and reversible and is a key post-transcriptional regulator.
Qiang Feng +7 more
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