Results 21 to 30 of about 3,540,807 (288)

RNA modification mapping with JACUSA2 [PDF]

Genome Biology, 2022
Abstract Several high-throughput antibody-free methods for RNA modification detection from sequencing data have been developed. We present JACUSA2 as a versatile software solution and comprehensive analysis framework for RNA modification detection assays that are based on either the Illumina or Nanopore platform ...
Michael Piechotta, Isabel S. Naarmann-de Vries, Qi Wang, Janine Altmüller, Christoph Dieterich   +4 more
openaire   +3 more sources

RNA modifications and their role in gene expression. [PDF]

Front Mol Biosci
Post-transcriptional RNA modifications have recently emerged as critical regulators of gene expression programs. Understanding normal tissue development and disease susceptibility requires knowledge of the various cellular mechanisms which control gene ...
Artika IM, Arianti R, Demény MÁ, Kristóf E.   +3 more
europepmc   +2 more sources

The RNA modification database [PDF]

Nucleic Acids Research, 1996
The RNA modification database provides a comprehensive listing of posttranscriptionally modified nucleosides from all RNAs, and is maintained as an updated version of the initial printed report [Limbach,P.A., Crain,P.F. and McCloskey,J.A. (1994)Nucleic Acids Res. , 22, 2183-2196].
Pamela F. Crain, James A. McCloskey
openaire   +4 more sources

Detection of RNA modifications [PDF]

RNA Biology, 2010
RNA nucleotide modifications are typically of low abundance and frequently go unnoticed by standard detection methods of molecular biology and cell biology. With a burst of knowledge intruding from such diverse areas as genomics, structural biology, regulation of gene expression and immunology, it becomes increasingly clear that many exciting functions
Stefanie, Kellner, Jürgen, Burhenne, Mark, Helm   +2 more
openaire   +2 more sources

Instrumental analysis of RNA modifications [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2021
Organisms from all domains of life invest a substantial amount of energy for the introduction of RNA modifications into nearly all transcripts studied to date. Instrumental analysis of RNA can focus on the modified residues and reveal the function of these epitranscriptomic marks.
Yasemin Yoluç, Gregor Ammann, Pierre Barraud, Manasses Jora, Patrick A. Limbach, Yuri Motorin, Virginie Marchand, Carine Tisné, Kayla Borland, Stefanie Kellner   +9 more
openaire   +3 more sources

MODOMICS: a database of RNA modifications and related information. 2023 update

Nucleic Acids Research, 2023
The MODOMICS database was updated with recent data and now includes new data types related to RNA modifications. Changes to the database include an expanded modification catalog, encompassing both natural and synthetic residues identified in RNA ...
Andrea Cappannini, Angana Ray, Elżbieta Purta, Sunandan Mukherjee, Pietro Boccaletto, S. N. Moafinejad, Antony Lechner, Charles Barchet, B. Klaholz, F. Stefaniak, J. Bujnicki   +10 more
semanticscholar   +1 more source

Dynamic RNA modifications in gene expression regulation

Cell, 2017
Over one hundred types of chemical modifications have been identified in cellular RNAs. While the 5’ cap modification and the poly(A) tail of eukaryotic messenger RNA play key roles in regulation, internal modifications are gaining attention for their ...
I. A. Roundtree, M. Evans, T. Pan, Chuan He   +3 more
semanticscholar   +1 more source

Mitochondrial RNA modifications shape metabolic plasticity in metastasis

Nature, 2022
Aggressive and metastatic cancers show enhanced metabolic plasticity1, but the precise underlying mechanisms of this remain unclear. Here we show how two NOP2/Sun RNA methyltransferase 3 (NSUN3)-dependent RNA modifications—5-methylcytosine (m5C) and its ...
S. Delaunay, Gloria Pascual, B. Feng, Kevin Klann, Mikaela Behm, A. Hotz-Wagenblatt, Karsten Richter, K. Zaoui, E. Herpel, Christian Münch, S. Dietmann, J. Hess, S. Benitah, M. Frye   +13 more
semanticscholar   +1 more source

ALKBHs-facilitated RNA modifications and de-modifications [PDF]

DNA Repair, 2016
The AlkB gene that protects E.coli against methylation damage to DNA was identified more than 3 decades ago. 20 years later, the AlkB protein was shown to catalyze repair of methylated DNA base lesions by oxidative demethylation. Two human AlkB homologs were characterized with similar DNA repair activities and seven additional human AlkB homologs were ...
Endalkachew, A Alemu, Chuan, He, Arne, Klungland   +2 more
openaire   +2 more sources

Direct detection of RNA modifications and structure using single-molecule nanopore sequencing

Cell Genomics, 2022
Summary: Modifications are present on many classes of RNA, including tRNA, rRNA, and mRNA. These modifications modulate diverse biological processes such as genetic recoding and mRNA export and folding. In addition, modifications can be introduced to RNA
William Stephenson, Roham Razaghi, Steven Busan, Kevin M. Weeks, Winston Timp, Peter Smibert   +5 more
doaj   +1 more source