Results 21 to 30 of about 520,942 (256)
Direct detection of RNA modifications and structure using single-molecule nanopore sequencing
Cell Genomics, 2022 Summary: Modifications are present on many classes of RNA, including tRNA, rRNA, and mRNA. These modifications modulate diverse biological processes such as genetic recoding and mRNA export and folding. In addition, modifications can be introduced to RNA
William Stephenson +5 more
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Post-Transcriptional Regulation of Viral RNA through Epitranscriptional Modification
Cells, 2021 The field of mRNA modifications has been steadily growing in recent years as technologies have improved and the importance of these residues became clear.
David G. Courtney
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Detection technologies for RNA modifications
Experimental & Molecular Medicine, 2022 AbstractTo date, more than 170 chemical modifications have been characterized in RNA, providing a new layer of gene expression regulation termed the ‘epitranscriptome’. RNA modification detection methods and tools advance the functional studies of the epitranscriptome.
Zhang, Yan, Lu, Liang, Li, Xiaoyu
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RNA modifications can affect RNase H1-mediated PS-ASO activity
Molecular Therapy: Nucleic Acids, 2022 Phosphorothioate modified antisense oligonucleotides (PS-ASOs) can reduce gene expression through hybridization to target RNAs and subsequent cleavage by RNase H1.
Katelyn A. Doxtader Lacy +3 more
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A New Epigenetic Crosstalk: Chemical Modification Information Flow
Advanced Genetics, 2023 Central dogma is the most fundamental hypothesis in the field of molecular biology and explains the genetic information flow from DNA to protein. Beyond residue‐by‐residue transmission of sequential information, chemical modifications of DNA, RNA, and ...
Hongwoo Lee +2 more
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Cancer Management and Research, 2022 Zhiyuan Yang,1,2,* Siyu Zhang,1,2,* Tian Xia,1,2,* Yue Fan,1,2 Ying Shan,1,2 Kaiwen Zhang,1,2 Jiayan Xiong,1,2 Miao Gu,1,2 Bo You1,2 1Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Medical ...
Yang Z +8 more
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The impact of RNA modifications on the biology of DNA virus infection
European Journal of Cell Biology, 2022 Approximately 170 RNA modifications have been identified and these are critical for determining the fate and function of cellular RNAs. Similar to human transcripts, viral RNAs possess an extensive RNA modification landscape.
Suba Rajendren, John Karijolich
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Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis
Frontiers in Genetics, 2022 As a critical layer of epigenetics, RNA modifications demonstrate various molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate.
Hui-Ming Chen +9 more
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Understanding RNA modifications: the promises and technological bottlenecks of the ‘epitranscriptome’ [PDF]
Open Biology, 2017 The discovery of mechanisms that alter genetic information via RNA editing or introducing covalent RNA modifications points towards a complexity in gene expression that challenges long-standing concepts.
Matthias Schaefer +2 more
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The role of RNA modification in hepatocellular carcinoma
Frontiers in Pharmacology, 2022 Hepatocellular carcinoma (HCC) is a highly mortal type of primary liver cancer. Abnormal epigenetic modifications are present in HCC, and RNA modification is dynamic and reversible and is a key post-transcriptional regulator.
Qiang Feng +7 more
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