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The regulation of antiviral innate immunity through non-m6A RNA modifications [PDF]
Frontiers in Immunology, 2023 The post-transcriptional RNA modifications impact the dynamic regulation of gene expression in diverse biological and physiological processes. Host RNA modifications play an indispensable role in regulating innate immune responses against virus infection
Shenghai Shen +2 more
doaj +2 more sources
Immunomodulatory role of RNA modifications in sex hormone-dependent cancers [PDF]
Frontiers in ImmunologyRecent studies have identified that RNA epigenetic modifications, including m6A, m1A, m5C, etc, play pivotal roles in tumor progression. These modifications influence mRNA stability, RNA processing, translational efficiency, and decoding precision ...
Yujia Jiang +5 more
doaj +3 more sources
Emerging Roles and Mechanisms of RNA Modifications in Neurodegenerative Diseases and Glioma [PDF]
CellsDespite a long history of research, neurodegenerative diseases and malignant brain tumor gliomas are both considered incurable, facing challenges in the development of treatments.
Ami Kobayashi +5 more
doaj +2 more sources
RNA modifications in cancer immune therapy: regulators of immune cells and immune checkpoints [PDF]
Frontiers in ImmunologyRNA modifications are epigenetic changes that alter the structure and function of RNA molecules, playing a crucial role in the onset, progression, and treatment of cancer.
Xiangyu Qin +13 more
doaj +3 more sources
RNA modifications and cancer [PDF]
RNA Biology, 2020 RNA plays essential roles in not only translating nucleic acids into proteins, but also in gene regulation, environmental interactions and many human diseases. Nature uses over 150 chemical modifications to decorate RNA and diversify its functions. With the fast-growing RNA research in the burgeoning field of 'epitranscriptome', a term describes post ...
Phensinee Haruehanroengra +4 more
openaire +2 more sources
RNA Modifications in Genomic RNA of Influenza A Virus and the Relationship between RNA Modifications and Viral Infection [PDF]
, 2021 Recent studies about the transcriptome-wide presence of RNA modifications have revealed their importance in many cellular functions. Nevertheless, information about RNA modifications in viral RNA is scarce, especially for negative-strand RNA viruses ...
Yuki Furuse
core +1 more source
PRMD: an integrated database for plant RNA modifications [PDF]
, 2023 The scope and function of RNA modifications in model plant systems have been extensively studied, resulting in the identification of an increasing number of novel RNA modifications in recent years.
Qian, Q. +18 more
core +1 more source
Novel Modifications in RNA [PDF]
ACS Chemical Biology, 2011 The past several years have seen numerous reports of new chemical modifications for use in RNA. In addition, in that time period, we have seen the discovery of several previously unknown naturally occurring modifications that impart novel properties on the parent RNAs.
Kelly, Phelps +2 more
openaire +2 more sources
Shaping the Bacterial Epitranscriptome—5′‐Terminal and Internal RNA Modifications [PDF]
, 2021 All domains of life utilize a diverse set of modified ribonucleotides that can impact the sequence, structure, function, stability, and the fate of RNAs, as well as their interactions with other molecules. Today, more than 160 different RNA modifications
Nadiia Pozhydaieva +5 more
core +1 more source
RNA modification mapping with JACUSA2 [PDF]
Genome Biology, 2022 Abstract Several high-throughput antibody-free methods for RNA modification detection from sequencing data have been developed. We present JACUSA2 as a versatile software solution and comprehensive analysis framework for RNA modification detection assays that are based on either the Illumina or Nanopore platform ...
Michael Piechotta +4 more
openaire +3 more sources