The Impact of Epitranscriptomics on Antiviral Innate Immunity
Viruses, 2022 Epitranscriptomics, i.e., chemical modifications of RNA molecules, has proven to be a new layer of modulation and regulation of protein expression, asking for the revisiting of some aspects of cellular biology.
Sara Cristinelli +2 more
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Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation [PDF]
Cell GenomicsSummary: As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms.
Haozhe Wang +10 more
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Epitranscriptomic modifications for enhancing abiotic stress resistance in plants [PDF]
Frontiers in Plant ScienceClimate change significantly impedes agricultural growth, development, and production. Plants adapt to environmental changes via the plasticity given by essential genes, which are regulated at the post-/transcriptional level. Gene regulation in plants is
Yunmin Zeng +7 more
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Spliceosomal snRNA Epitranscriptomics [PDF]
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Pedro Morais, Hironori Adachi, Yi-Tao Yu
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Statistical modeling of immunoprecipitation efficiency of MeRIP-seq data enabled accurate detection and quantification of epitranscriptome [PDF]
Computational and Structural Biotechnology JournalBackground: Recent advancements in epitranscriptomics highlight reversible RNA modifications as crucial regulators, with N6-methyladenosine (m6A) being abundant in eukaryotic mRNAs.
Haozhe Wang +8 more
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Crosstalk between skeletal muscle and the brain during physical activity - in search of epigenetic mechanisms [PDF]
EpigeneticsRecent research highlights the crucial role of muscle-brain crosstalk in metabolic regulation, particularly in individuals with type 2 diabetes and obesity. Myokines, protein hormones secreted by skeletal muscle, play a crucial role in this communication,
Cayla Boycott +10 more
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METTL4 regulates synaptic UCP2 N6-adenosine methylation to mediate pain hypersensitivity in female mice [PDF]
Cellular and Molecular Life SciencesEpitranscriptomics modifications play an important role in sex-dependent biological phenomena. N6-adenosine methylation (m6A), the most prevalent epitranscriptomics modification in eukaryotic mRNA, participates in regulating various sex-specific ...
Yanqiong Wu +15 more
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Epitranscriptomic signatures in blood: emerging biomarkers for diagnosis of diabetes and its complications [PDF]
Frontiers in Cell and Developmental BiologyType 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by chronic hyperglycemia, insulin resistance, and progressive β-cell dysfunction.
Marketa Hlavackova +8 more
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Epitranscriptomics of SARS-CoV-2 Infection
Frontiers in Cell and Developmental Biology, 2022 Recent studies on the epitranscriptomic code of SARS-CoV-2 infection have discovered various RNA modifications, such as N6-methyladenosine (m6A), pseudouridine (Ψ), and 2′-O-methylation (Nm).
Amin Izadpanah +4 more
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Resolving sequencing-based HIV-1 epitranscriptomics [PDF]
EpigenomicsBosmeny MS, Mamede JI, Gagnon KT.
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