Spliceosomal snRNA Epitranscriptomics [PDF]
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Pedro Morais, Hironori Adachi, Yi-Tao Yu
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Epitranscriptomics as a New Layer of Regulation of Gene Expression in Skeletal Muscle: Known Functions and Future Perspectives [PDF]
International Journal of Molecular Sciences, 2023 Epitranscriptomics refers to post-transcriptional regulation of gene expression via RNA modifications and editing that affect RNA functions. Many kinds of modifications of mRNA have been described, among which are N6-methyladenosine (m6A), N1 ...
Carol Imbriano +2 more
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The rise of epitranscriptomics: recent developments and future directions [PDF]
Trends in Pharmacological Sciences, 2023 The epitranscriptomics field has undergone tremendous growth since the discovery that the RNA N6-methyladenosine (m6A) modification is reversible and is distributed throughout the transcriptome.
Guo-Li Ming, Chuan He
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The Impact of Epitranscriptomics on Antiviral Innate Immunity
Viruses, 2022 Epitranscriptomics, i.e., chemical modifications of RNA molecules, has proven to be a new layer of modulation and regulation of protein expression, asking for the revisiting of some aspects of cellular biology.
Beril Mersinoglu +2 more
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Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation [PDF]
Cell GenomicsSummary: As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms.
Haozhe Wang +10 more
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Emerging Role of Environmental Epitranscriptomics and RNA Modifications in Parkinson’s Disease [PDF]
Journal of Parkinson’s DiseaseEnvironmental risk factors and gene-environment interactions play a critical role in Parkinson’s disease (PD). However, the relatively large contribution of environmental risk factors in the overwhelming majority of PD cases has been widely neglected in ...
John T. Gionco, Alison I. Bernstein
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More than a duologue: In-depth insights into epitranscriptomics and ferroptosis
Frontiers in Cell and Developmental Biology, 2022 Beyond transcription, RNA molecules are enzymatically modified to influence the biological functions of living organisms. The term “epitranscriptomics” describes the changes in RNA strands aside from altering the innate sequences.
Justin Chak Ting Cheung +5 more
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Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications [PDF]
Non-Coding RNA, 2021 It is now commonly accepted that most of the mammalian genome is transcribed as RNA, yet less than 2% of such RNA encode for proteins. A majority of transcribed RNA exists as non-protein-coding RNAs (ncRNAs) with various functions. Because of the lack of
Venkata Naga Srikanth Garikipati +1 more
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SRSF2 plays an unexpected role as reader of m5C on mRNA, linking epitranscriptomics to cancer
Molecular Cell, 2023 A common mRNA modification is 5-methylcytosine (m5C), whose role in gene-transcript processing and cancer remains unclear. Here, we identify serine/arginine-rich splicing factor 2 (SRSF2) as a reader of m5C and impaired SRSF2 m5C binding as a potential ...
Akihide Yoshimi +2 more
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Epitranscriptomic modifications for enhancing abiotic stress resistance in plants [PDF]
Frontiers in Plant ScienceClimate change significantly impedes agricultural growth, development, and production. Plants adapt to environmental changes via the plasticity given by essential genes, which are regulated at the post-/transcriptional level. Gene regulation in plants is
Yunmin Zeng +7 more
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