Spliceosomal snRNA Epitranscriptomics [PDF]
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Yi-Tao Yu, Yu Yi-Tao, Adachi Hironori
exaly +5 more sources
The Impact of Epitranscriptomics on Antiviral Innate Immunity
Viruses, 2022 Epitranscriptomics, i.e., chemical modifications of RNA molecules, has proven to be a new layer of modulation and regulation of protein expression, asking for the revisiting of some aspects of cellular biology.
Sara Cristinelli +2 more
exaly +3 more sources
Epitranscriptomic modifications for enhancing abiotic stress resistance in plants [PDF]
Frontiers in Plant ScienceClimate change significantly impedes agricultural growth, development, and production. Plants adapt to environmental changes via the plasticity given by essential genes, which are regulated at the post-/transcriptional level. Gene regulation in plants is
Yunmin Zeng +7 more
doaj +2 more sources
Statistical modeling of immunoprecipitation efficiency of MeRIP-seq data enabled accurate detection and quantification of epitranscriptome [PDF]
Computational and Structural Biotechnology JournalBackground: Recent advancements in epitranscriptomics highlight reversible RNA modifications as crucial regulators, with N6-methyladenosine (m6A) being abundant in eukaryotic mRNAs.
Haozhe Wang +8 more
doaj +2 more sources
More than a duologue: In-depth insights into epitranscriptomics and ferroptosis
Frontiers in Cell and Developmental Biology, 2022 Beyond transcription, RNA molecules are enzymatically modified to influence the biological functions of living organisms. The term “epitranscriptomics” describes the changes in RNA strands aside from altering the innate sequences.
Dong Yujuan
exaly +3 more sources
Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation [PDF]
Cell GenomicsSummary: As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms.
Haozhe Wang +10 more
doaj +2 more sources
Epitranscriptomics: An Additional Regulatory Layer in Plants’ Development and Stress Response
Plants, 2022 Epitranscriptomics has added a new layer of regulatory machinery to eukaryotes, and the advancement of sequencing technology has revealed more than 170 post-transcriptional modifications in various types of RNAs, including messenger RNA (mRNA), transfer ...
Babar Usman +2 more
exaly +3 more sources
Emerging Roles of Long Noncoding RNAs in Breast Cancer Epigenetics and Epitranscriptomics
Frontiers in Cell and Developmental Biology, 2022 Breast carcinogenesis is a multistep process that involves both genetic and epigenetic changes. Epigenetics refers to reversible changes in gene expression that are not accompanied by changes in gene sequence.
Elżbieta Wanowska +2 more
exaly +3 more sources
Crosstalk between skeletal muscle and the brain during physical activity - in search of epigenetic mechanisms [PDF]
EpigeneticsRecent research highlights the crucial role of muscle-brain crosstalk in metabolic regulation, particularly in individuals with type 2 diabetes and obesity. Myokines, protein hormones secreted by skeletal muscle, play a crucial role in this communication,
Cayla Boycott +10 more
doaj +2 more sources
Epitranscriptomics in the development, functions, and disorders of cancer stem cells
Frontiers in Oncology, 2023 Biomolecular modifications play an important role in the development of life, and previous studies have investigated the role of DNA and proteins. In the last decade, with the development of sequencing technology, the veil of epitranscriptomics has been ...
Linlin Hao, Zhongshan Liu, Hao Linlin
exaly +3 more sources