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The Impact of Epitranscriptomics on Antiviral Innate Immunity
Viruses, 2022 Epitranscriptomics, i.e., chemical modifications of RNA molecules, has proven to be a new layer of modulation and regulation of protein expression, asking for the revisiting of some aspects of cellular biology.
Sara Cristinelli, Angela Ciuffi
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Statistical modeling of immunoprecipitation efficiency of MeRIP-seq data enabled accurate detection and quantification of epitranscriptome [PDF]
Computational and Structural Biotechnology JournalBackground: Recent advancements in epitranscriptomics highlight reversible RNA modifications as crucial regulators, with N6-methyladenosine (m6A) being abundant in eukaryotic mRNAs.
Haozhe Wang +8 more
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Epitranscriptomic modifications for enhancing abiotic stress resistance in plants [PDF]
Frontiers in Plant ScienceClimate change significantly impedes agricultural growth, development, and production. Plants adapt to environmental changes via the plasticity given by essential genes, which are regulated at the post-/transcriptional level. Gene regulation in plants is
Yunmin Zeng +7 more
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Statistical modeling of single-cell epitranscriptomics enabled trajectory and regulatory inference of RNA methylation [PDF]
Cell GenomicsSummary: As a fundamental mechanism for gene expression regulation, post-transcriptional RNA methylation plays versatile roles in various biological processes and disease mechanisms.
Haozhe Wang +10 more
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Crosstalk between skeletal muscle and the brain during physical activity - in search of epigenetic mechanisms [PDF]
EpigeneticsRecent research highlights the crucial role of muscle-brain crosstalk in metabolic regulation, particularly in individuals with type 2 diabetes and obesity. Myokines, protein hormones secreted by skeletal muscle, play a crucial role in this communication,
Cayla Boycott +10 more
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Spliceosomal snRNA Epitranscriptomics
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell ...
Pedro Morais, Hironori Adachi, Yi-Tao Yu
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Epitranscriptomics of SARS-CoV-2 Infection
Frontiers in Cell and Developmental Biology, 2022 Recent studies on the epitranscriptomic code of SARS-CoV-2 infection have discovered various RNA modifications, such as N6-methyladenosine (m6A), pseudouridine (Ψ), and 2′-O-methylation (Nm).
Amin Izadpanah +4 more
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Journal of Translational Medicine, 2023 Glioblastoma (GBM) comprises 45.6% of all primary malignant brain cancers and is one of the most common and aggressive intracranial tumors in adults.
Christian K. Ramsoomair +3 more
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RNA Modification Related Diseases and Sensing Methods
Applied Sciences, 2023 Epitranscriptomics is the study of RNA base modifications, including functionally relevant transcriptomic changes. Epitranscriptomics has been actively studied in recent years and has been reported to play important roles in development, homeostasis, the
Mayuka Ohkawa, Masamitsu Konno
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Immunity and autoantibodies of a mouse strain with autistic-like behavior
Brain, Behavior, & Immunity - Health, 2020 Female and male mice of the BTBR T+Itpr3tf/J (BTBR) strain have behaviors that resemble autism spectrum disorder. In comparison to C57BL/6 (B6) mice, BTBR mice have elevated humoral immunity, in that they have naturally high serum IgG levels and generate
Mohammad Nizam Uddin +6 more
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