Results 21 to 30 of about 3,015 (181)

Regulatory Mechanisms of the RNA Modification m6A and Significance in Brain Function in Health and Disease

Frontiers in Cellular Neuroscience, 2021
RNA modifications have emerged as an additional layer of regulatory complexity governing the function of almost all species of RNA. N6-methyladenosine (m6A), the addition of methyl groups to adenine residues, is the most abundant and well understood RNA ...
Justine Mathoux, Justine Mathoux, David C. Henshall, David C. Henshall, Gary P. Brennan, Gary P. Brennan   +5 more
doaj   +1 more source

Multivariate Analysis of RNA Chemistry Marks Uncovers Epitranscriptomics-Based Biomarker Signature for Adult Diffuse Glioma Diagnostics

, 2022
International audienceOne of the main challenges in cancer management relates to the discovery of reliable biomarkers, which could guide decision-making and predict treatment outcome.
Attina, A., David, Alexandre, Rigau, V., Rivals, Eric, Amalric, A., Burel Vandenbos, F., Fontaine, D., Hirtz, Christophe, Relier, S., M. Baroncini, Hugnot, J.P., A. Attina, V. Rigau, Fontaine, Denys, A. David, Rivals, E., F. Burel Vandenbos, E. Rivals, Bauchet, L., S. Relier, Amalric, Amandine, Koumare, Izoudine Blaise, Duffau, Hugues, Bauchet, Luc, Burel-Vandenbos, Fanny, Hirtz, C., Koumare, I.B., Baroncini, M., I.B. Koumare, Baroncini, Marc, D. Fontaine, Rigau, Valérie, C. Hirtz, L. Bauchet, David, A., A. Amalric, Relier, Sébastien, Attina, Aurore, Duffau, H., H. Duffau, J.P. Hugnot, Hugnot, Jean-Philippe   +41 more
core   +1 more source

A panoramic view of RNA modifications: exploring new frontiers

Genome Biology, 2018
Meeting report on the Cold Spring Harbor Asia conference on RNA Modifications and Epitranscriptomics, held in Suzhou, China, 13–17 November, 2017.
Zijun Zhang, Eddie Park, Lan Lin, Yi Xing   +3 more
doaj   +1 more source

More than a duologue: In-depth insights into epitranscriptomics and ferroptosis

Frontiers in Cell and Developmental Biology, 2022
Beyond transcription, RNA molecules are enzymatically modified to influence the biological functions of living organisms. The term “epitranscriptomics” describes the changes in RNA strands aside from altering the innate sequences.
Justin Chak Ting Cheung, Guangzheng Deng, Nathalie Wong, Yujuan Dong, Yujuan Dong, Simon Siu Man Ng   +5 more
doaj   +1 more source

Chemistry and biology of oxidatively damaged RNA nucleotides [PDF]

RSC Chemical Biology
Nucleic acid damage under oxidative stress conditions is a well-established phenomenon relevant to evolution of all living organisms. While well investigated for DNA, cellular RNAs are also a subject of extensive damage, featuring similar reactivity ...
Kasturi Raorane, Marlies Weber, Virginie Marchand, Mark Helm, Yuri Motorin   +4 more
doaj   +1 more source

Emerging Roles of Long Noncoding RNAs in Breast Cancer Epigenetics and Epitranscriptomics

Frontiers in Cell and Developmental Biology, 2022
Breast carcinogenesis is a multistep process that involves both genetic and epigenetic changes. Epigenetics refers to reversible changes in gene expression that are not accompanied by changes in gene sequence.
Elżbieta Wanowska, Elżbieta Wanowska, Klaudia Samorowska, Michał Wojciech Szcześniak   +3 more
doaj   +1 more source

Interrogating the Escherichia coli Epitranscriptome Via CRISPR Interference and Nanopore Native RNA Sequencing. [PDF]

Microbiologyopen
Epitranscriptomics is understudied in bacteria but has the ability to modulate antimicrobial resistance, virulence and pathogenicity. Pitt et al. implement two cutting‐edge techniques: CRISPR interference and Nanopore direct RNA sequencing along with functional assays to study RNA modifications in Escherichia coli.
Pitt ME, Zhang J, Nguyen ANT, Hall MB, Jebeli L, Featherstone LA, Myers GSA, Scott NE, Coin LJM.   +8 more
europepmc   +2 more sources

Clinical Perspectives in Epitranscriptomics [PDF]

Epitranscriptomics, the study of reversible and dynamic chemical marks on the RNA, is rapidly emerging as a pivotal field in post-transcriptional gene expression regulation.
Esteller, M, Santos-Pujol, Eloy, Quero-Dotor, Carlos   +2 more
core   +1 more source

The emerging epitranscriptomics of long noncoding RNAs [PDF]

, 2020
The pervasive transcription of genomes into long noncoding RNAs has been amply demonstrated in recent years and garnered much attention. Similarly, emerging 'epitranscriptomics' research has shown that chemically modified nucleosides, thought to be ...
Shafik, Andrew, Evers, Maurits, Sibbritt, Tennille, Preiss, Thomas, Schumann, Ulrike   +4 more
core   +1 more source

Deciphering Epitranscriptome: Modification of mRNA Bases Provides a New Perspective for Post-transcriptional Regulation of Gene Expression

Frontiers in Cell and Developmental Biology, 2021
Gene regulation depends on dynamic and reversibly modifiable biological and chemical information in the epigenome/epitranscriptome. Accumulating evidence suggests that messenger RNAs (mRNAs) are generated in flashing bursts in the cells in a precisely ...
Suresh Kumar, Trilochan Mohapatra
doaj   +1 more source