Results 21 to 30 of about 2,699 (211)
Journal of Translational Medicine, 2023 Glioblastoma (GBM) comprises 45.6% of all primary malignant brain cancers and is one of the most common and aggressive intracranial tumors in adults.
Christian K. Ramsoomair +3 more
doaj +1 more source
Immunity and autoantibodies of a mouse strain with autistic-like behavior
Brain, Behavior, & Immunity - Health, 2020 Female and male mice of the BTBR T+Itpr3tf/J (BTBR) strain have behaviors that resemble autism spectrum disorder. In comparison to C57BL/6 (B6) mice, BTBR mice have elevated humoral immunity, in that they have naturally high serum IgG levels and generate
Mohammad Nizam Uddin +6 more
doaj +1 more source
RNA Modification Related Diseases and Sensing Methods
Applied Sciences, 2023 Epitranscriptomics is the study of RNA base modifications, including functionally relevant transcriptomic changes. Epitranscriptomics has been actively studied in recent years and has been reported to play important roles in development, homeostasis, the
Mayuka Ohkawa, Masamitsu Konno
doaj +1 more source
Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications
Non-Coding RNA, 2021 It is now commonly accepted that most of the mammalian genome is transcribed as RNA, yet less than 2% of such RNA encode for proteins. A majority of transcribed RNA exists as non-protein-coding RNAs (ncRNAs) with various functions. Because of the lack of
Venkata Naga Srikanth Garikipati +1 more
doaj +1 more source
The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity
Frontiers in Immunology, 2023 The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has had a significant impact on global social and economic stability.
Xuan Wang +6 more
doaj +1 more source
Epitranscriptomics and epigenetics: two sides of the same coin? [PDF]
Clin Epigenetics: Gene expression is an intricate biological process that bridges gap between the genotype and the phenotype. Canonical and hereditable epigenetic mechanisms, such as histone and DNA modifications, regulate the release of genetic information encoded in ...
Bove G, Del Gaudio N, Altucci L.
europepmc +2 more sources
The Epitranscriptome and Innate Immunity [PDF]
PLOS Genetics, 2015 Our knowledge of the variety and abundances of RNA base modifications is rapidly increasing. Modified bases have critical roles in tRNAs, rRNAs, translation, splicing, RNA interference, and other RNA processes, and are now increasingly detected in all types of transcripts.
O'Connell, Mary +2 more
openaire +4 more sources
Frontiers in Genetics, 2020 A major trend in the epitranscriptomics field over the last 5 years has been the high-throughput analysis of RNA modifications by a combination of specific chemical treatment(s), followed by library preparation and deep sequencing.
Florian Pichot +10 more
doaj +1 more source
, 2021 Reprograming the N6-methyladenosine (m6A) landscape is a promising therapeutic strategy against recalcitrant leukemia. In this study, we synthesized gold nanorods (GNRs) of different aspect ratios using a binary surfactant mixture of hexadecyltrimethyl ...
Yangyang Du (2589379) +9 more
core +6 more sources
World Journal of Clinical Oncology, 2018 The functional impact of modifications of cellular RNAs, including mRNAs, miRNAs and lncRNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported.
Tusup, Marina +2 more
openaire +3 more sources