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Clinician's Guide to Epitranscriptomics: An Example of N1-Methyladenosine (m1A) RNA Modification and Cancer. [PDF]
Life (Basel)Epitranscriptomics is the study of modifications of RNA molecules by small molecular residues, such as the methyl (-CH3) group. These modifications are inheritable and reversible.
Kvolik Pavić A +4 more
europepmc +2 more sources
Emerging Role of Epitranscriptomics in Diabetes Mellitus and Its Complications
Frontiers in Endocrinology, 2022 Diabetes mellitus (DM) and its related complications are among the leading causes of disability and mortality worldwide. Substantial studies have explored epigenetic regulation that is involved in the modifications of DNA and proteins, but RNA ...
X. Geng, Zheng Li, Ying Yang
exaly +2 more sources
The role of RNA-modifying proteins in renal cell carcinoma [PDF]
Cell Death and DiseaseGene expression is one of the most critical cellular processes. It is controlled by complex mechanisms at the genomic, epigenomic, transcriptomic, and proteomic levels. Any aberration in these mechanisms can lead to dysregulated gene expression.
Muna A. Alhammadi +3 more
doaj +2 more sources
Epitranscriptomics and epiproteomics in cancer drug resistance: therapeutic implications
Signal Transduction and Targeted Therapy, 2020 Drug resistance is a major hurdle in cancer treatment and a key cause of poor prognosis. Epitranscriptomics and epiproteomics are crucial in cell proliferation, migration, invasion, and epithelial–mesenchymal transition.
shaowei dong, Litu Zhang, Zhe-Sheng Chen
exaly +2 more sources
Nanoscale Research Letters, 2022 Although various strategies have been included in nanotoxicity evaluation, epitranscriptomics has rarely been integrated into this field. In this proof-of-concept study, N6-methyladenosine (m6A) changes of mRNA in HEK293T cells induced by three bovine ...
Jinbin Pan +6 more
doaj +2 more sources
Journal of Personalized Medicine, 2022 With the advent of genome-wide screening methods—beginning with microarray technologies and moving onto next generation sequencing methods—the era of precision and personalized medicine was born.
Farah R Zahir
exaly +2 more sources
Epitranscriptomics in the development, functions, and disorders of cancer stem cells
Frontiers in Oncology, 2023 Biomolecular modifications play an important role in the development of life, and previous studies have investigated the role of DNA and proteins. In the last decade, with the development of sequencing technology, the veil of epitranscriptomics has been ...
Linlin Hao +4 more
doaj +2 more sources
METTL4 regulates synaptic UCP2 N6-adenosine methylation to mediate pain hypersensitivity in female mice [PDF]
Cellular and Molecular Life SciencesEpitranscriptomics modifications play an important role in sex-dependent biological phenomena. N6-adenosine methylation (m6A), the most prevalent epitranscriptomics modification in eukaryotic mRNA, participates in regulating various sex-specific ...
Yanqiong Wu +15 more
doaj +2 more sources
Epitranscriptomics: An Additional Regulatory Layer in Plants’ Development and Stress Response
Plants, 2022 Epitranscriptomics has added a new layer of regulatory machinery to eukaryotes, and the advancement of sequencing technology has revealed more than 170 post-transcriptional modifications in various types of RNAs, including messenger RNA (mRNA), transfer ...
Yasira Shoaib +3 more
doaj +2 more sources
Cancer epitranscriptomics in a nutshell
Current Opinion in Genetics and Development, 2022 Remarkable technological progress has led to breakthrough discoveries in epitranscriptomics, reshaping our understanding of modifications decorating RNA.
Francois Fuks, Audrey Penning
exaly +2 more sources