Results 21 to 30 of about 2,313 (187)
RNA Modification Related Diseases and Sensing Methods
Applied Sciences, 2023 Epitranscriptomics is the study of RNA base modifications, including functionally relevant transcriptomic changes. Epitranscriptomics has been actively studied in recent years and has been reported to play important roles in development, homeostasis, the
Mayuka Ohkawa, Masamitsu Konno
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Viral Epitranscriptomics [PDF]
Journal of Virology, 2017 ABSTRACT Although it has been known for over 40 years that eukaryotic mRNAs bear internal base modifications, it is only in the last 5 years that the importance of these modifications has begun to come into focus. The most common mRNA modification, the addition of a methyl group to the N 6 ...
Edward M, Kennedy +3 more
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Editorial: Epitranscriptomics: The Novel RNA Frontier
Frontiers in Bioengineering and Biotechnology, 2018 Giovanni Nigita +2 more
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Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications
Non-Coding RNA, 2021 It is now commonly accepted that most of the mammalian genome is transcribed as RNA, yet less than 2% of such RNA encode for proteins. A majority of transcribed RNA exists as non-protein-coding RNAs (ncRNAs) with various functions. Because of the lack of
Venkata Naga Srikanth Garikipati +1 more
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The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity
Frontiers in Immunology, 2023 The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has had a significant impact on global social and economic stability.
Xuan Wang +6 more
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The Epitranscriptome and Innate Immunity [PDF]
PLOS Genetics, 2015 Our knowledge of the variety and abundances of RNA base modifications is rapidly increasing. Modified bases have critical roles in tRNAs, rRNAs, translation, splicing, RNA interference, and other RNA processes, and are now increasingly detected in all types of transcripts.
O'Connell, Mary +2 more
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Cancer epitranscriptomics in a nutshell [PDF]
Current Opinion in Genetics & Development, 2022 Remarkable technological progress has led to breakthrough discoveries in epitranscriptomics, reshaping our understanding of modifications decorating RNA. The past decade has seen a tremendous endeavor to describe the nature, functions, and biological roles of messenger RNA (mRNA) modifications, positioning epitranscriptomics as a crucial pillar in ...
Primac, Irina +2 more
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Frontiers in Genetics, 2020 A major trend in the epitranscriptomics field over the last 5 years has been the high-throughput analysis of RNA modifications by a combination of specific chemical treatment(s), followed by library preparation and deep sequencing.
Florian Pichot +10 more
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World Journal of Clinical Oncology, 2018 The functional impact of modifications of cellular RNAs, including mRNAs, miRNAs and lncRNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported.
Tusup, Marina +2 more
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The Arabidopsis epitranscriptome
Current Opinion in Plant Biology, 2015 The most prevalent internal modification of plant messenger RNAs, N(6)-methyladenosine (m(6)A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has recently attracted renewed attention.
Fray, Rupert G., Simpson, Gordon G.
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