Clinical Perspectives in Epitranscriptomics [PDF]
Current Opinion in Genetics & DevelopmentEpitranscriptomics, the study of reversible and dynamic chemical marks on the RNA, is rapidly emerging as a pivotal field in post-transcriptional gene expression regulation.
Esteller, Manel +2 more
core +4 more sources
Epitranscriptomics in myeloid malignancies
Blood Science, 2022 In eukaryotes, gene expression is highly orchestrated not only by genomic promoters and enhancers but also by covalent modifications added to either chromatin or RNAs.
Li Han, Jianjun Chen, Rui Su
doaj +4 more sources
Epitranscriptomics and epigenetics: two sides of the same coin? [PDF]
Clin EpigeneticsGene expression is an intricate biological process that bridges gap between the genotype and the phenotype. Canonical and hereditable epigenetic mechanisms, such as histone and DNA modifications, regulate the release of genetic information encoded in DNA
Bove G, Del Gaudio N, Altucci L.
europepmc +2 more sources
The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer
Seminars in Cancer Biology, 2022 RNA binding proteins that act at the post-transcriptional level display a richness of mechanisms to modulate the transcriptional output and respond to changing cellular conditions. The family of IGF2BP proteins recognize mRNAs modified by methylation and
Sonia Guil
exaly +2 more sources
Epitranscriptomics of SARS-CoV-2 Infection
Frontiers in Cell and Developmental Biology, 2022 Recent studies on the epitranscriptomic code of SARS-CoV-2 infection have discovered various RNA modifications, such as N6-methyladenosine (m6A), pseudouridine (Ψ), and 2′-O-methylation (Nm).
Amin Izadpanah +4 more
doaj +2 more sources
Statistical modeling of immunoprecipitation efficiency of MeRIP-seq data enabled accurate detection and quantification of epitranscriptome [PDF]
Computational and Structural Biotechnology JournalBackground: Recent advancements in epitranscriptomics highlight reversible RNA modifications as crucial regulators, with N6-methyladenosine (m6A) being abundant in eukaryotic mRNAs.
Haozhe Wang +8 more
doaj +2 more sources
Epitranscriptomics in Normal and Malignant Hematopoiesis [PDF]
International Journal of Molecular Sciences, 2020 Epitranscriptomics analyze the biochemical modifications borne by RNA and their downstream influence. From this point of view, epitranscriptomics represent a new layer for the control of genetic information and can affect a variety of molecular processes
Crescenzio Francesco Minervini +2 more
exaly +3 more sources
Epitranscriptomics as a Candidate Universal Modulator of Dormancy Transitions. [PDF]
Ecol EvolDormancy has been widely recognized as an evolutionarily conserved strategy that enables cells and organisms to endure environmental stress, resource scarcity, or developmental arrest. While transcriptional regulation has been extensively studied in this
Pashay Ahi E.
europepmc +2 more sources
Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology.
Developmental Dynamics, EarlyView.Maternal effects, encompassing both genetic (maternally expressed gene products) and non-genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA-level mechanisms remain incompletely resolved.
E. P. Ahi
semanticscholar +2 more sources
Epitranscriptomics in liver disease: Basic concepts and therapeutic potential
Journal of Hepatology, 2020 The development of next-generation sequencing technology and the discovery of specific antibodies targeting chemically modified nucleotides have paved the way for a new era of epitranscriptomics.
Zhicong Zhao, Rui Su, Jianjun Chen
exaly +2 more sources