Results 11 to 20 of about 3,015 (181)

Multivariate Analysis of RNA Chemistry Marks Uncovers Epitranscriptomics-Based Biomarker Signature for Adult Diffuse Glioma Diagnostics

, 2023
National audienceOne of the main challenges in cancer management relates to the discovery of reliable biomarkers, which could guide decision-making and predict treatment outcome.
Amalric, Amandine, Duffau, Hugues, David, Alexandre, Bauchet, Luc, Rivals, Eric, Hirtz, Christophe, Koumare, Izoudine, B, Hugnot, Jean-Philippe, P, Baroncini, Marc, Rigau, Valérie, Fontaine, Denys, Burel Vandenbos, F, Relier, Sébastien, Attina, Aurore   +13 more
core   +4 more sources

Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications

Non-Coding RNA, 2021
It is now commonly accepted that most of the mammalian genome is transcribed as RNA, yet less than 2% of such RNA encode for proteins. A majority of transcribed RNA exists as non-protein-coding RNAs (ncRNAs) with various functions. Because of the lack of
Venkata Naga Srikanth Garikipati, Shizuka Uchida   +1 more
doaj   +1 more source

The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity

Frontiers in Immunology, 2023
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has had a significant impact on global social and economic stability.
Xuan Wang, Zecheng Chang, Tingting Zhao, Weiyao Zhong, Jingwei Shi, Guoqing Wang, Xuesong Xu   +6 more
doaj   +1 more source

Cancer epitranscriptomics in a nutshell.

, 2022
Remarkable technological progress has led to breakthrough discoveries in epitranscriptomics, reshaping our understanding of modifications decorating RNA.
Penning, Audrey, Primac, Irina, Fuks, François   +2 more
core   +1 more source

RNA Aptamers and Epitranscriptomics: Charting Unexplored Territories in RNA Biology. [PDF]

Mol Diagn Ther
The fields of RNA aptamers and epitranscriptomics have each emerged as powerful dimensions of RNA biology, yet their conceptual and mechanistic overlap remains largely unexplored.
Khorshid M, Ahi EP.
europepmc   +2 more sources

Holistic Optimization of Bioinformatic Analysis Pipeline for Detection and Quantification of 2′-O-Methylations in RNA by RiboMethSeq

Frontiers in Genetics, 2020
A major trend in the epitranscriptomics field over the last 5 years has been the high-throughput analysis of RNA modifications by a combination of specific chemical treatment(s), followed by library preparation and deep sequencing.
Florian Pichot, Florian Pichot, Florian Pichot, Virginie Marchand, Lilia Ayadi, Lilia Ayadi, Valérie Bourguignon-Igel, Valérie Bourguignon-Igel, Mark Helm, Yuri Motorin, Yuri Motorin   +10 more
doaj   +1 more source

RNA m6A Alterations Induced by Biomineralization Nanoparticles: A Proof-of-Concept Study of Epitranscriptomics for Nanotoxicity Evaluation

Nanoscale Research Letters, 2022
Although various strategies have been included in nanotoxicity evaluation, epitranscriptomics has rarely been integrated into this field. In this proof-of-concept study, N6-methyladenosine (m6A) changes of mRNA in HEK293T cells induced by three bovine ...
Jinbin Pan, Jiaojiao Wang, Kun Fang, Wenjing Hou, Bing Li, Jie Zhao, Xinlong Ma   +6 more
doaj   +1 more source

Epitranscriptomics of cardiovascular diseases (Review)

, 2022
RNA modifications have recently become the focus of attention due to their extensive regulatory effects in a vast array of cellular networks and signaling pathways.
Bacopoulou, Flora, Pierouli, Katerina, Papakonstantinou, Eleni, Diakou, Kalliopi, Mitsis, Thanasis, Chrousos, George, Vlachakis, Dimitrios, Sanoudou, Despina, Dragoumani, Konstantina, Leptidis, Stefanos   +9 more
core   +1 more source

Epitranscriptomics of Mammalian Mitochondrial Ribosomal RNA

Cells, 2020
Modified nucleotides are present in all ribosomal RNA molecules. Mitochondrial ribosomes are unique to have a set of methylated residues that includes universally conserved ones, those that could be found either in bacterial or in archaeal/eukaryotic ...
Ivan Laptev, Olga Dontsova, Petr Sergiev
doaj   +1 more source

Epitranscriptomic N6-Methyladenosine Profile of SARS-CoV-2-Infected Human Lung Epithelial Cells

Microbiology Spectrum, 2023
N6-methyladenosine (m6A) is a dynamic posttranscriptional RNA modification that plays an important role in determining transcript fate. The functional consequence of m6A deposition is dictated by a group of host proteins that specifically recognize and ...
Stacia Phillips, Tarun Mishra, Shaubhagya Khadka, Dana Bohan, Constanza E. Espada, Wendy Maury, Li Wu   +6 more
doaj   +1 more source