Results 41 to 50 of about 3,015 (181)

Epitranscriptomics and epigenetics: two sides of the same coin? [PDF]

Clin Epigenetics
: Gene expression is an intricate biological process that bridges gap between the genotype and the phenotype. Canonical and hereditable epigenetic mechanisms, such as histone and DNA modifications, regulate the release of genetic information encoded in ...
Bove G, Del Gaudio N, Altucci L.
europepmc   +2 more sources

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

Advanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao, Jian Zhang, Qi Qian, Min Jiang, Yu Liu, Yan Geng, Nan Cui, Qi Guo, Jie Guo   +8 more
wiley   +1 more source

3′ RNA Uridylation in Epitranscriptomics, Gene Regulation, and Disease [PDF]

, 2018
Emerging evidence implicates a wide range of post-transcriptional RNA modifications that play crucial roles in fundamental biological processes including regulating gene expression. Collectively, they are known as epitranscriptomics.
Miriam R. Menezes, John P. Hagan, Julien Balzeau   +2 more
core   +1 more source

NSUN2‐Mediated m5C Modification of TGFB1 in Trophoblasts Remodels Macrophage Function to Prevent URSA

Advanced Science, EarlyView.
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu, Xinkui Liu, Xiaoyan Yu, Qiaoqiao Han, Feifei Shi, Weiwei Song, Lu Liu, Chu Chu, Chenyang Shen, Zhen Zhang, Xia Li   +10 more
wiley   +1 more source

Mutant KRAS‐m6A Epitranscriptome Axis Promotes Colorectal Cancer and is a Therapeutic Target

Advanced Science, EarlyView.
Mutant KRAS‐m6A axis promotes colorectal cancer (CRC) progression. Mutant KRAS stabilizes METTL3, leading to increased m6A‐modified BCL9L mRNA and translation of BCL9L protein. BCL9L in turn mediates TGF‐β secretion to induce differentiation of Treg and an immunosuppressive microenvironment.
Danyu Chen, Pingmei Huang, Ruizhi Tao, Fenfen Ji, Qinyao Wei, Lok Hin Ko, Lianxin Zhou, Huarong Chen, Alvin Cheung, Wei Kang, Ko Fai To, Jun Yu, Chi Chun Wong   +12 more
wiley   +1 more source

Epitranscriptomics of Ischemic Heart Disease—The IHD-EPITRAN Study Design and Objectives [PDF]

, 2021
Epitranscriptomic modifications in RNA can dramatically alter the way our genetic code is deciphered. Cells utilize these modifications not only to maintain physiological processes, but also to respond to extracellular cues and various stressors.
Simpanen, J. (Jarmo), Syrjälä, S. (Simo), Khan, J. (Jahangir), Jan Kiss, Stark, C. (Christoffer), Antti Vento, Eskin, Arda, Kati Oksaharju, Savinainen, Kimmo, Annu Nummi, Tuohinen, Suvi, Suihko, S. (Satu), Jari Laurikka, Jormalainen, Mikko, Kankuri, E. (Esko), Shintaro Katayama, Pia Bäckström, Koivisto, Pertti, Vento, Antti, Peter Raivio, Jussi Ropponen, Kari Teittinen, Daria Blokhina, Laine, Mika, Mervaala, E. (Eero), Esko Kankuri, Blokhina, D. (Daria), Lemström, K. (Karl), Vainikka, Tiina, Laurikka, Jari, Eero Mervaala, Simo Syrjälä, Mikko Jormalainen, Nurcan Tuncbag, Kiss, J. (Jan), Sikorski, V. (Vilbert), Markku Kaarne, Juvonen, T. (Tatu), Karjalainen, Pasi, Ropponen, J. (Jussi), Rajala, Helena, Jahangir Khan, Tuncbag, Nurcan, Tiina Vainikka, Lemström, Karl, Kimmo Savinainen, Christoffer Stark, Simpanen, Jarmo, Oksaharju, K. (Kati), Pasi Karjalainen, Tommi Vähäsilta, Karelson, M. (Mati), Vento, A. (Antti), Laine, M. (Mika), Raivio, P. (Peter), Bäckström, P. (Pia), Vähäsilta, T. (Tommi), Kaarne, Markku, Fausto Biancari, Karjalainen, P. (Pasi), Laurikka, J. (Jari), Helena Rajala, Tuohinen, S. (Suvi), Nykänen, A. (Antti), Vainikka, T. (Tiina), Lalowski, M. (Maciej), Sikorski, Vilbert, Teittinen, Kari, Rajala, H. (Helena), Vilbert Sikorski, Elomaa, O. (Outi), Lalowski, Maciej, Elomaa, Outi, Suihko, Satu, Dahlbacka, Sebastian, Karelson, Mati, Nummi, A. (Annu), Tuncbag, N. (Nurcan), Nykänen, Antti, Mervaala, Eero, Kankuri, Esko, Vähäsilta, Tommi, Maciej Lalowski, Outi Elomaa, Tuohinen, Suvi Sirkku, Ropponen, Jussi, Sebastian Dahlbacka, Raivio, Peter, Katayama, Shintaro, Eskin, Arda, Bäckström, Pia, Dahlbacka, S. (Sebastian), Oksaharju, Kati, Antti Nykänen, Pertti Koivisto, Juvonen, Tatu, Kaarne, M. (Markku), Biancari, F. (Fausto), Stark, Christoffer, Jormalainen, M. (Mikko), Blokhina, Daria, Teittinen, K. (Kari), Syrjälä, Simo, Khan, Jahangir, Biancari, Fausto, Savinainen, K. (Kimmo), Arda Eskin, Mati Karelson, Nummi, Annu, Koivisto, P. (Pertti), Satu Suihko, Suvi Tuohinen, Mika Laine, Kiss, Jan, Karl Lemström, Tatu Juvonen, Katayama, S. (Shintaro), Ropponen, Jussi O, Jarmo Simpanen, Eskin, A. (Arda)   +119 more
core   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

A Metabolic‐Epigenetic Axis of AARS1/IGF2BP3‐K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence

Advanced Science, EarlyView.
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Peng Jiang, Yunfeng Zheng, Chenfan Tian, Yuan Tu, Xiaoxia Chang, Jiaxin Yu, Hangkun Yu, Chunxia Gong, Jie Xiong, Philip N. Baker, Yong Fu, Chao Tong   +11 more
wiley   +1 more source

Viral Epitranscriptomics

, 2017
Although it has been known for over 40 years that eukaryotic mRNAs bear internal base modifications, it is only in the last 5 years that the importance of these modifications has begun to come into focus.
Edward M. Kennedy, David G. Courtney, Bryan R. Cullen, Kevin Tsai   +3 more
core   +1 more source