Results 41 to 50 of about 2,699 (211)
A panoramic view of RNA modifications: exploring new frontiers
Genome Biology, 2018 Meeting report on the Cold Spring Harbor Asia conference on RNA Modifications and Epitranscriptomics, held in Suzhou, China, 13–17 November, 2017.
Zijun Zhang +3 more
doaj +1 more source
The emerging epitranscriptomics of long noncoding RNAs [PDF]
, 2020 The pervasive transcription of genomes into long noncoding RNAs has been amply demonstrated in recent years and garnered much attention. Similarly, emerging 'epitranscriptomics' research has shown that chemically modified nucleosides, thought to be ...
Shafik, Andrew +4 more
core +1 more source
Epitranscriptomics modifier pentostatin indirectly triggers Toll-like receptor 3 and can enhance immune infiltration in tumors [PDF]
, 2022 The adenosine deaminase inhibitor 2'-deoxycoformycin (pentostatin, Nipent) has been used since 1982 to treat leukemia and lymphoma, but its mode of action is still unknown. Pentostatin was reported to decrease methylation of cellular RNA.
Tusup, Marina; https://orcid.org/ +2 more
core +1 more source
The mammalian mitochondrial epitranscriptome
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019 Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been emerging as an important regulatory feature of mitochondrial gene expression.
Rebelo-Guiomar, Pedro +3 more
openaire +3 more sources
More than a duologue: In-depth insights into epitranscriptomics and ferroptosis
Frontiers in Cell and Developmental Biology, 2022 Beyond transcription, RNA molecules are enzymatically modified to influence the biological functions of living organisms. The term “epitranscriptomics” describes the changes in RNA strands aside from altering the innate sequences.
Justin Chak Ting Cheung +5 more
doaj +1 more source
Positioning Europe for the EPITRANSCRIPTOMICS challenge
, 2021 The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built.
Jan Kyselovic (11281170) +59 more
core +1 more source
The non-coding epitranscriptome in cancer [PDF]
Briefings in Functional Genomics, 2021 Abstract Post-synthesis modification of biomolecules is an efficient way of regulating and optimizing their functions. The human epitranscriptome includes a variety of more than 100 modifications known to exist in all RNA subtypes.
Miano, Valentina +3 more
openaire +2 more sources
Emerging Roles of Long Noncoding RNAs in Breast Cancer Epigenetics and Epitranscriptomics
Frontiers in Cell and Developmental Biology, 2022 Breast carcinogenesis is a multistep process that involves both genetic and epigenetic changes. Epigenetics refers to reversible changes in gene expression that are not accompanied by changes in gene sequence.
Elżbieta Wanowska +3 more
doaj +1 more source
, 2023 National audienceOne of the main challenges in cancer management relates to the discovery of reliable biomarkers, which could guide decision-making and predict treatment outcome.
Amalric, Amandine +13 more
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3′ RNA Uridylation in Epitranscriptomics, Gene Regulation, and Disease [PDF]
, 2018 Emerging evidence implicates a wide range of post-transcriptional RNA modifications that play crucial roles in fundamental biological processes including regulating gene expression. Collectively, they are known as epitranscriptomics.
Miriam R. Menezes +2 more
core +1 more source