Results 41 to 50 of about 2,313 (187)

Deciphering Epitranscriptome: Modification of mRNA Bases Provides a New Perspective for Post-transcriptional Regulation of Gene Expression

Frontiers in Cell and Developmental Biology, 2021
Gene regulation depends on dynamic and reversibly modifiable biological and chemical information in the epigenome/epitranscriptome. Accumulating evidence suggests that messenger RNAs (mRNAs) are generated in flashing bursts in the cells in a precisely ...
Suresh Kumar, Trilochan Mohapatra
doaj   +1 more source

The Epitranscriptome in Translation Regulation [PDF]

Cold Spring Harbor Perspectives in Biology, 2018
The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output.
Eyal, Peer, Sharon, Moshitch-Moshkovitz, Gideon, Rechavi, Dan, Dominissini   +3 more
openaire   +2 more sources

Alteration of m6A RNA Methylation in Heart Failure With Preserved Ejection Fraction

Frontiers in Cardiovascular Medicine, 2021
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease, in which its pathogenesis is very complex and far from defined.
Beijian Zhang, Beijian Zhang, Beijian Zhang, Yamei Xu, Xiaotong Cui, Hao Jiang, Hao Jiang, Hao Jiang, Wei Luo, Wei Luo, Wei Luo, Xinyu Weng, Xinyu Weng, Xinyu Weng, Yun Wang, Yun Wang, Yun Wang, Yun Wang, Yuhong Zhao, Aijun Sun, Aijun Sun, Aijun Sun, Aijun Sun, Junbo Ge, Junbo Ge, Junbo Ge, Junbo Ge   +26 more
doaj   +1 more source

Interplay Between N6-Methyladenosine (m6A) and Non-coding RNAs in Cell Development and Cancer

Frontiers in Cell and Developmental Biology, 2019
RNA chemical modifications in coding and non-coding RNAs have been known for decades. They are generally installed by specific enzymes and, in some cases, can be read and erased by other specific proteins. The impact of RNA chemical modifications on gene
Francesco Fazi, Alessandro Fatica
doaj   +1 more source

Epitranscriptomics: mapping methods and beyond

BioTechniques, 2018
The field of epigenetics has changed the way we look at both DNA and proteins. Could the same be true for RNA? Joseph Martin discusses. [Graphic: see text]
Joseph Martin
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m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

How Do You Identify m6 A Methylation in Transcriptomes at High Resolution? A Comparison of Recent Datasets

Frontiers in Genetics, 2020
A flurry of methods has been developed in recent years to identify N6-methyladenosine (m6A) sites across transcriptomes at high resolution. This raises the need to understand both the common features and those that are unique to each method.
Charlotte Capitanchik, Patrick Toolan-Kerr, Patrick Toolan-Kerr, Nicholas M. Luscombe, Nicholas M. Luscombe, Nicholas M. Luscombe, Jernej Ule, Jernej Ule   +7 more
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Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

The role of RNA-modifying proteins in renal cell carcinoma

Cell Death and Disease
Gene expression is one of the most critical cellular processes. It is controlled by complex mechanisms at the genomic, epigenomic, transcriptomic, and proteomic levels. Any aberration in these mechanisms can lead to dysregulated gene expression.
Muna A. Alhammadi, Khuloud Bajbouj, Iman M. Talaat, Rifat Hamoudi   +3 more
doaj   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source