Results 31 to 40 of about 2,699 (211)

The Arabidopsis epitranscriptome

Current Opinion in Plant Biology, 2015
The most prevalent internal modification of plant messenger RNAs, N(6)-methyladenosine (m(6)A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has recently attracted renewed attention.
Fray, Rupert G., Simpson, Gordon G.
openaire   +3 more sources

mRNA epitranscriptomics. [PDF]

RNA
Epitranscriptomics refers to chemical changes in RNAs and includes numerous chemical types with varying stoichiometry and functions. RNA modifications are highly diverse in chemistry and respond in cell-type- and cell-state-dependent manners that enable and facilitate the execution of a wide array of biological functions.
Meyer KD, Pan T.
europepmc   +3 more sources

Epitranscriptomics as a New Layer of Regulation of Gene Expression in Skeletal Muscle: Known Functions and Future Perspectives [PDF]

, 2023
Epitranscriptomics refers to post-transcriptional regulation of gene expression via RNA modifications and editing that affect RNA functions. Many kinds of modifications of mRNA have been described, among which are N6-methyladenosine (m6A), N1 ...
Cavioli, Giorgia, Viviana Moresi, Imbriano, Carol, Maretti, Eleonora, Silvia Belluti, Susanna Molinari, Belluti, Silvia, Carol Imbriano, Eleonora Maretti, Giorgia Cavioli, Alessandra Renzini, Renzini, Alessandra, Moresi, Viviana, Molinari, Susanna   +13 more
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Epitranscriptomics of Mammalian Mitochondrial Ribosomal RNA

Cells, 2020
Modified nucleotides are present in all ribosomal RNA molecules. Mitochondrial ribosomes are unique to have a set of methylated residues that includes universally conserved ones, those that could be found either in bacterial or in archaeal/eukaryotic ...
Ivan Laptev, Olga Dontsova, Petr Sergiev
doaj   +1 more source

RNA m6A Alterations Induced by Biomineralization Nanoparticles: A Proof-of-Concept Study of Epitranscriptomics for Nanotoxicity Evaluation

Nanoscale Research Letters, 2022
Although various strategies have been included in nanotoxicity evaluation, epitranscriptomics has rarely been integrated into this field. In this proof-of-concept study, N6-methyladenosine (m6A) changes of mRNA in HEK293T cells induced by three bovine ...
Jinbin Pan, Jiaojiao Wang, Kun Fang, Wenjing Hou, Bing Li, Jie Zhao, Xinlong Ma   +6 more
doaj   +1 more source

Cracking the epitranscriptome [PDF]

RNA, 2016
Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made ...
openaire   +2 more sources

Multivariate Analysis of RNA Chemistry Marks Uncovers Epitranscriptomics-Based Biomarker Signature for Adult Diffuse Glioma Diagnostics

, 2022
International audienceOne of the main challenges in cancer management relates to the discovery of reliable biomarkers, which could guide decision-making and predict treatment outcome.
Attina, A., David, Alexandre, Rigau, V., Rivals, Eric, Amalric, A., Burel Vandenbos, F., Fontaine, D., Hirtz, Christophe, Relier, S., M. Baroncini, Hugnot, J.P., A. Attina, V. Rigau, Fontaine, Denys, A. David, Rivals, E., F. Burel Vandenbos, E. Rivals, Bauchet, L., S. Relier, Amalric, Amandine, Koumare, Izoudine Blaise, Duffau, Hugues, Bauchet, Luc, Burel-Vandenbos, Fanny, Hirtz, C., Koumare, I.B., Baroncini, M., I.B. Koumare, Baroncini, Marc, D. Fontaine, Rigau, Valérie, C. Hirtz, L. Bauchet, David, A., A. Amalric, Relier, Sébastien, Attina, Aurore, Duffau, H., H. Duffau, J.P. Hugnot, Hugnot, Jean-Philippe   +41 more
core   +1 more source

Epitranscriptomic N6-Methyladenosine Profile of SARS-CoV-2-Infected Human Lung Epithelial Cells

Microbiology Spectrum, 2023
N6-methyladenosine (m6A) is a dynamic posttranscriptional RNA modification that plays an important role in determining transcript fate. The functional consequence of m6A deposition is dictated by a group of host proteins that specifically recognize and ...
Stacia Phillips, Tarun Mishra, Shaubhagya Khadka, Dana Bohan, Constanza E. Espada, Wendy Maury, Li Wu   +6 more
doaj   +1 more source

Epitranscriptomics of Ischemic Heart Disease—The IHD-EPITRAN Study Design and Objectives [PDF]

, 2021
Epitranscriptomic modifications in RNA can dramatically alter the way our genetic code is deciphered. Cells utilize these modifications not only to maintain physiological processes, but also to respond to extracellular cues and various stressors.
Simpanen, J. (Jarmo), Syrjälä, S. (Simo), Khan, J. (Jahangir), Jan Kiss, Stark, C. (Christoffer), Antti Vento, Eskin, Arda, Kati Oksaharju, Savinainen, Kimmo, Annu Nummi, Tuohinen, Suvi, Suihko, S. (Satu), Jari Laurikka, Jormalainen, Mikko, Kankuri, E. (Esko), Shintaro Katayama, Pia Bäckström, Koivisto, Pertti, Vento, Antti, Peter Raivio, Jussi Ropponen, Kari Teittinen, Daria Blokhina, Laine, Mika, Mervaala, E. (Eero), Esko Kankuri, Blokhina, D. (Daria), Lemström, K. (Karl), Vainikka, Tiina, Laurikka, Jari, Eero Mervaala, Simo Syrjälä, Mikko Jormalainen, Nurcan Tuncbag, Kiss, J. (Jan), Sikorski, V. (Vilbert), Markku Kaarne, Juvonen, T. (Tatu), Karjalainen, Pasi, Ropponen, J. (Jussi), Rajala, Helena, Jahangir Khan, Tuncbag, Nurcan, Tiina Vainikka, Lemström, Karl, Kimmo Savinainen, Christoffer Stark, Simpanen, Jarmo, Oksaharju, K. (Kati), Pasi Karjalainen, Tommi Vähäsilta, Karelson, M. (Mati), Vento, A. (Antti), Laine, M. (Mika), Raivio, P. (Peter), Bäckström, P. (Pia), Vähäsilta, T. (Tommi), Kaarne, Markku, Fausto Biancari, Karjalainen, P. (Pasi), Laurikka, J. (Jari), Helena Rajala, Tuohinen, S. (Suvi), Nykänen, A. (Antti), Vainikka, T. (Tiina), Lalowski, M. (Maciej), Sikorski, Vilbert, Teittinen, Kari, Rajala, H. (Helena), Vilbert Sikorski, Elomaa, O. (Outi), Lalowski, Maciej, Elomaa, Outi, Suihko, Satu, Dahlbacka, Sebastian, Karelson, Mati, Nummi, A. (Annu), Tuncbag, N. (Nurcan), Nykänen, Antti, Mervaala, Eero, Kankuri, Esko, Vähäsilta, Tommi, Maciej Lalowski, Outi Elomaa, Tuohinen, Suvi Sirkku, Ropponen, Jussi, Sebastian Dahlbacka, Raivio, Peter, Katayama, Shintaro, Eskin, Arda, Bäckström, Pia, Dahlbacka, S. (Sebastian), Oksaharju, Kati, Antti Nykänen, Pertti Koivisto, Juvonen, Tatu, Kaarne, M. (Markku), Biancari, F. (Fausto), Stark, Christoffer, Jormalainen, M. (Mikko), Blokhina, Daria, Teittinen, K. (Kari), Syrjälä, Simo, Khan, Jahangir, Biancari, Fausto, Savinainen, K. (Kimmo), Arda Eskin, Mati Karelson, Nummi, Annu, Koivisto, P. (Pertti), Satu Suihko, Suvi Tuohinen, Mika Laine, Kiss, Jan, Karl Lemström, Tatu Juvonen, Katayama, S. (Shintaro), Ropponen, Jussi O, Jarmo Simpanen, Eskin, A. (Arda)   +119 more
core   +3 more sources

Regulatory Mechanisms of the RNA Modification m6A and Significance in Brain Function in Health and Disease

Frontiers in Cellular Neuroscience, 2021
RNA modifications have emerged as an additional layer of regulatory complexity governing the function of almost all species of RNA. N6-methyladenosine (m6A), the addition of methyl groups to adenine residues, is the most abundant and well understood RNA ...
Justine Mathoux, Justine Mathoux, David C. Henshall, David C. Henshall, Gary P. Brennan, Gary P. Brennan   +5 more
doaj   +1 more source