Results 31 to 40 of about 5,351 (235)

Epitranscriptomics: A New Layer of microRNA Regulation in Cancer

Cancers, 2021
Simple Summary MicroRNAs are small non-coding RNAs, acting as post-transcriptional regulators of gene expression. In the last two decades, their role in cancer as oncogenes (oncomir), as well as tumor suppressors, has been extensively demonstrated ...
Veronica DE PAOLIS, Elisa Lorefice, Elisa Orecchini   +2 more
exaly   +2 more sources

Crosstalk between skeletal muscle and the brain during physical activity - in search of epigenetic mechanisms [PDF]

Epigenetics
Recent research highlights the crucial role of muscle-brain crosstalk in metabolic regulation, particularly in individuals with type 2 diabetes and obesity. Myokines, protein hormones secreted by skeletal muscle, play a crucial role in this communication,
Cayla Boycott, Ewa Kilanczyk, Huiying A. Zhang, Jiaxi Zhang, Arian Abolhassani, Malgorzata Kubiak, Jan Celichowski, Katarzyna Kryściak, Dominika Gruszka, Joanna H. Sliwowska, Barbara Stefanska   +10 more
doaj   +2 more sources

Epitranscriptomics: mapping methods and beyond [PDF]

BioTechniques, 2018
The field of epigenetics has changed the way we look at both DNA and proteins. Could the same be true for RNA? Joseph Martin discusses. [Graphic: see text]
Joseph Martin
doaj   +2 more sources

Epitranscriptomic signatures in blood: emerging biomarkers for diagnosis of diabetes and its complications [PDF]

Frontiers in Cell and Developmental Biology
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by chronic hyperglycemia, insulin resistance, and progressive β-cell dysfunction.
Marketa Hlavackova, Daniel Benak, Kristyna Holzerova, Petra Alanova, Jaroslav Hrdlicka, Miloslava Chalupova, Barbora Opletalova, Bohuslav Ostadal, Frantisek Kolar   +8 more
doaj   +2 more sources

RNA Modifications: Current Understandings and Future Perspectives [PDF]

MedComm (2020)
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Xiao S, Xiang T, Yang C, Wang X, Huang G, Luo F, Xie Z, Chen Y.   +7 more
europepmc   +2 more sources

The epitranscriptome toolbox [PDF]

Cell, 2022
In the last decade, the notion that mRNA modifications are involved in regulation of gene expression was demonstrated in thousands of studies. To date, new technologies and methods allow accurate identification, transcriptome-wide mapping, and functional characterization of a growing number of RNA modifications, providing important insights into the ...
Moshitch-Moshkovitz, Sharon, Dominissini, Dan, Rechavi, Gideon   +2 more
openaire   +2 more sources

Editorial: Epitranscriptomics: The Novel RNA Frontier [PDF]

Frontiers in Bioengineering and Biotechnology, 2018
Giovanni Nigita, Mario Acunzo, William Chi Shing Cho, Carlo M. Croce   +3 more
doaj   +3 more sources

Viral Epitranscriptomics [PDF]

Journal of Virology, 2017
ABSTRACT Although it has been known for over 40 years that eukaryotic mRNAs bear internal base modifications, it is only in the last 5 years that the importance of these modifications has begun to come into focus. The most common mRNA modification, the addition of a methyl group to the N 6 ...
Edward M, Kennedy, David G, Courtney, Kevin, Tsai, Bryan R, Cullen   +3 more
openaire   +2 more sources

mRNA epitranscriptomics. [PDF]

RNA
Epitranscriptomics refers to chemical changes in RNAs and includes numerous chemical types with varying stoichiometry and functions. RNA modifications are highly diverse in chemistry and respond in cell-type- and cell-state-dependent manners that enable and facilitate the execution of a wide array of biological functions.
Meyer KD, Pan T.
europepmc   +3 more sources

The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses

Journal of Translational Medicine, 2023
Glioblastoma (GBM) comprises 45.6% of all primary malignant brain cancers and is one of the most common and aggressive intracranial tumors in adults.
Christian K. Ramsoomair, Michele Ceccarelli, John D. Heiss, Ashish H. Shah   +3 more
doaj   +1 more source