Results 31 to 40 of about 2,313 (187)
mRNA epitranscriptomics. [PDF]
RNAEpitranscriptomics refers to chemical changes in RNAs and includes numerous chemical types with varying stoichiometry and functions. RNA modifications are highly diverse in chemistry and respond in cell-type- and cell-state-dependent manners that enable and facilitate the execution of a wide array of biological functions.
Meyer KD, Pan T.
europepmc +3 more sources
Epitranscriptomics of Mammalian Mitochondrial Ribosomal RNA
Cells, 2020 Modified nucleotides are present in all ribosomal RNA molecules. Mitochondrial ribosomes are unique to have a set of methylated residues that includes universally conserved ones, those that could be found either in bacterial or in archaeal/eukaryotic ...
Ivan Laptev, Olga Dontsova, Petr Sergiev
doaj +1 more source
Nanoscale Research Letters, 2022 Although various strategies have been included in nanotoxicity evaluation, epitranscriptomics has rarely been integrated into this field. In this proof-of-concept study, N6-methyladenosine (m6A) changes of mRNA in HEK293T cells induced by three bovine ...
Jinbin Pan +6 more
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Cracking the epitranscriptome [PDF]
RNA, 2016 Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made ...
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Epitranscriptomic N6-Methyladenosine Profile of SARS-CoV-2-Infected Human Lung Epithelial Cells
Microbiology Spectrum, 2023 N6-methyladenosine (m6A) is a dynamic posttranscriptional RNA modification that plays an important role in determining transcript fate. The functional consequence of m6A deposition is dictated by a group of host proteins that specifically recognize and ...
Stacia Phillips +6 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 RNA modifications have emerged as an additional layer of regulatory complexity governing the function of almost all species of RNA. N6-methyladenosine (m6A), the addition of methyl groups to adenine residues, is the most abundant and well understood RNA ...
Justine Mathoux +5 more
doaj +1 more source
The non-coding epitranscriptome in cancer [PDF]
Briefings in Functional Genomics, 2021 Abstract Post-synthesis modification of biomolecules is an efficient way of regulating and optimizing their functions. The human epitranscriptome includes a variety of more than 100 modifications known to exist in all RNA subtypes.
Miano, Valentina +3 more
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A panoramic view of RNA modifications: exploring new frontiers
Genome Biology, 2018 Meeting report on the Cold Spring Harbor Asia conference on RNA Modifications and Epitranscriptomics, held in Suzhou, China, 13–17 November, 2017.
Zijun Zhang +3 more
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The mammalian mitochondrial epitranscriptome
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019 Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been emerging as an important regulatory feature of mitochondrial gene expression.
Rebelo-Guiomar, Pedro +3 more
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Dawn of Epitranscriptomic Medicine [PDF]
Circulation: Genomic and Precision Medicine, 2018 Medicine is at the crossroads of expanding disciplines. Prompt adaptation of medicine to each rapidly advancing research field, bridging bench to bedside, is a key step toward health improvement. Cardiovascular disease still ranks first among the mortality causes in the Western world, indicating a poor adaptation rate of cardiovascular medicine, albeit
Gatsiou A, Stellos K
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