Results 51 to 60 of about 2,699 (211)

Dawn of Epitranscriptomic Medicine [PDF]

Circulation: Genomic and Precision Medicine, 2018
Medicine is at the crossroads of expanding disciplines. Prompt adaptation of medicine to each rapidly advancing research field, bridging bench to bedside, is a key step toward health improvement. Cardiovascular disease still ranks first among the mortality causes in the Western world, indicating a poor adaptation rate of cardiovascular medicine, albeit
Gatsiou A, Stellos K
openaire   +3 more sources

Deciphering Epitranscriptome: Modification of mRNA Bases Provides a New Perspective for Post-transcriptional Regulation of Gene Expression

Frontiers in Cell and Developmental Biology, 2021
Gene regulation depends on dynamic and reversibly modifiable biological and chemical information in the epigenome/epitranscriptome. Accumulating evidence suggests that messenger RNAs (mRNAs) are generated in flashing bursts in the cells in a precisely ...
Suresh Kumar, Trilochan Mohapatra
doaj   +1 more source

Clinician's Guide to Epitranscriptomics: An Example of N¹-Methyladenosine (m¹A) RNA Modification and Cancer. [PDF]

Life (Basel)
Epitranscriptomics is the study of modifications of RNA molecules by small molecular residues, such as the methyl (-CH3) group. These modifications are inheritable and reversible.
Kvolik Pavić A, Čonkaš J, Mumlek I, Zubčić V, Ozretić P.   +4 more
europepmc   +2 more sources

Interplay Between N6-Methyladenosine (m6A) and Non-coding RNAs in Cell Development and Cancer

Frontiers in Cell and Developmental Biology, 2019
RNA chemical modifications in coding and non-coding RNAs have been known for decades. They are generally installed by specific enzymes and, in some cases, can be read and erased by other specific proteins. The impact of RNA chemical modifications on gene
Francesco Fazi, Alessandro Fatica
doaj   +1 more source

Alteration of m6A RNA Methylation in Heart Failure With Preserved Ejection Fraction

Frontiers in Cardiovascular Medicine, 2021
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease, in which its pathogenesis is very complex and far from defined.
Beijian Zhang, Beijian Zhang, Beijian Zhang, Yamei Xu, Xiaotong Cui, Hao Jiang, Hao Jiang, Hao Jiang, Wei Luo, Wei Luo, Wei Luo, Xinyu Weng, Xinyu Weng, Xinyu Weng, Yun Wang, Yun Wang, Yun Wang, Yun Wang, Yuhong Zhao, Aijun Sun, Aijun Sun, Aijun Sun, Aijun Sun, Junbo Ge, Junbo Ge, Junbo Ge, Junbo Ge   +26 more
doaj   +1 more source

The Epitranscriptome in Translation Regulation [PDF]

Cold Spring Harbor Perspectives in Biology, 2018
The cellular proteome reflects the total outcome of many regulatory mechanisms that affect the metabolism of messenger RNA (mRNA) along its pathway from synthesis to degradation. Accumulating evidence in recent years has uncovered the roles of a growing number of mRNA modifications in every step along this pathway, shaping translational output.
Eyal, Peer, Sharon, Moshitch-Moshkovitz, Gideon, Rechavi, Dan, Dominissini   +3 more
openaire   +2 more sources

Epitranscriptomics: mapping methods and beyond

BioTechniques, 2018
The field of epigenetics has changed the way we look at both DNA and proteins. Could the same be true for RNA? Joseph Martin discusses. [Graphic: see text]
Joseph Martin
doaj   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Epitranscriptomics of cardiovascular diseases (Review)

, 2022
RNA modifications have recently become the focus of attention due to their extensive regulatory effects in a vast array of cellular networks and signaling pathways.
Bacopoulou, Flora, Pierouli, Katerina, Papakonstantinou, Eleni, Diakou, Kalliopi, Mitsis, Thanasis, Chrousos, George, Vlachakis, Dimitrios, Sanoudou, Despina, Dragoumani, Konstantina, Leptidis, Stefanos   +9 more
core  

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source