Results 51 to 60 of about 5,351 (235)

Cancer metastasis under the magnifying glass of epigenetics and epitranscriptomics

Cancer Metastasis Review, 2023
Most of the cancer-associated mortality and morbidity can be attributed to metastasis. The role of epigenetic and epitranscriptomic alterations in cancer origin and progression has been extensively demonstrated during the last years.
M. Janin, V. Davalos, M. Esteller
semanticscholar   +1 more source

Methionine Adenosyltransferase 1a (MAT1A) Enhances Cell Survival During Chemotherapy Treatment and is Associated with Drug Resistance in Bladder Cancer PDX Mice. [PDF]

, 2019
Bladder cancer is among the top ten most common cancers, with about ~380,000 new cases and ~150,000 deaths per year worldwide. Tumor relapse following chemotherapy treatment has long been a significant challenge towards completely curing cancer.
de Vere White, Ralph, Ghosh, Paramita M, He, Wei, Hum, Nicholas R, Loots, Gabriela G, Martin, Kelly A, Pan, Chong-Xian, Sebastian, Aimy, Siddiqui, Salma   +8 more
core   +2 more sources

Flavin-dependent epitranscriptomic world [PDF]

Archives of Biochemistry and Biophysics, 2017
RNAs molecules fulfill key roles in the expression and regulation of the genetic information stored within the DNA chromosomes. In addition to the four canonical bases, U, C, A and G, RNAs harbor various chemically modified derivatives which are generated post-transcriptionally by specific enzymes acting directly at the polymer level.
Lombard, Murielle, Hamdane, Djemel
openaire   +3 more sources

tRNA biology in the omics era: Stress signalling dynamics and cancer progression. [PDF]

, 2017
Recent years have seen a burst in the number of studies investigating tRNA biology. With the transition from a gene-centred to a genome-centred perspective, tRNAs and other RNA polymerase III transcripts surfaced as active regulators of normal cell ...
Adelman, Anderson, Anderson, Arimbasseri, Arimbasseri, Barski, Bartholomew, Basturea, Behm-Ansmant, Blanco, Bogenhagen, Boguta, Bonhoure, Canella, Canella, Carlile, Carrire, Chan, Chan, Choi, Clarke, Conti, Core, Cozen, Crick, Danko, David, de Nadal, Deng, Dieci, Dittmar, Dittmar, Duechler, Ebhardt, Flusberg, Gingold, Goodarzi, Goodarzi, Granneman, Grewal, Guenther, Guy, Harismendy, Hiley, Hoagland, Holley, Honda, Hou, Huang, Hussain, Iida, Ishimura, Ivanov, Johnson, Jordan-Pla, Kadaba, Kassavetis, Kedinger, Khoddami, Kim, Kumar, Kumar, Kumar, Kutter, Lampson, Laplante, Li, Li, Lin, Linder, Liu, Liu, Lowe, Lund, Mahlab, Marchand, Mayer, Michels, Moqtaderi, Moqtaderi, Nagarajavel, Nedialkova, Noma, Oler, Oler, Orioli, Orioli, Pang, Pavesi, Pavon-Eternod, Pavon-Eternod, Percudani, Pershing, Phizicky, Pombo, Pugh, Qian, Raha, Renaud, Rhee, Rideout, Roberts, Roeder, Ross, Rudolph, Ryvkin, Saikia, Saikia, Sakurai, Sakurai, Schaefer, Schmitt, Schwartz, Shor, Shukla, Simms, Sutherland, Thurman, Torres, Torres, Turowski, Vannini, Varshney, Vilfan, Weinmann, White, Zheng, Zhou   +127 more
core   +1 more source

Writers, readers and erasers of RNA modifications in cancer [PDF]

, 2020
Although cancer was originally considered a disease driven only by genetic mutations, it has now been proven that it is also an epigenetic disease driven by DNA hypermethylation-associated silencing of tumor suppressor genes and aberrant histone ...
Bueno-Costa, Alberto, Esteller, M., Esteve-Puig, R., Universitat Autònoma de Barcelona   +3 more
core   +4 more sources

tRNA epitranscriptomics and biased codon are linked to proteome expression in [PDF]

, 2018
Among components of the translational machinery, ribonucleoside modifications on tRNAs are emerging as critical regulators of cell physiology and stress response. Here, we demonstrate highly coordinated behavior of the repertoire of tRNA modifications of
Aniweh, Yaw, Babu, Indrakanti Ramesh, Chionh, Yok Hian, Dedon, Peter C, Gu, Chen, Nah, Qianhui, Ng, Chee Sheng, Preiser, Peter R, Sinha, Ameya   +8 more
core   +1 more source

Editorial: Genetic, Epigenetic, and Epitranscriptomic Mechanisms Associated With Learning and Memory [PDF]

, 2022
Temple University.
Moore, Anna, Moore|
core   +1 more source

Epitranscriptomics of cancer

World Journal of Clinical Oncology, 2018
The functional impact of modifications of cellular RNAs, including mRNAs, miRNAs and lncRNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported.
Tusup, Marina, Kundig, Thoma, Pascolo, Steve   +2 more
openaire   +2 more sources

Epitranscriptomics of Mammalian Mitochondrial Ribosomal RNA

Cells, 2020
Modified nucleotides are present in all ribosomal RNA molecules. Mitochondrial ribosomes are unique to have a set of methylated residues that includes universally conserved ones, those that could be found either in bacterial or in archaeal/eukaryotic ...
Ivan Laptev, Olga Dontsova, Petr Sergiev
doaj   +1 more source

RNA epitranscriptomics dysregulation: A major determinant for significantly increased risk of ASD pathogenesis

Frontiers in Neuroscience, 2023
Autism spectrum disorders (ASDs) are perhaps the most severe, intractable and challenging child psychiatric disorders. They are complex, pervasive and highly heterogeneous and depend on multifactorial neurodevelopmental conditions.
A. Beopoulos, M. Géa, A. Fasano, F. Iris   +3 more
semanticscholar   +1 more source