Results 71 to 80 of about 5,351 (235)
Epitranscriptomic regulation of insecticide resistance [PDF]
Science Advances, 2021 A cytochrome P450 that confers insecticide resistance in whitefly is regulated by an epitranscriptomic mechanism.
Xin Yang +17 more
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PLoS Pathogens, 2022 “Epitranscriptomics” is the new RNA code that represents an ensemble of posttranscriptional RNA chemical modifications, which can precisely coordinate gene expression and biological processes.
Cassandra Catacalos +5 more
semanticscholar +1 more source
Dawn of Epitranscriptomic Medicine [PDF]
Circulation: Genomic and Precision Medicine, 2018 Medicine is at the crossroads of expanding disciplines. Prompt adaptation of medicine to each rapidly advancing research field, bridging bench to bedside, is a key step toward health improvement. Cardiovascular disease still ranks first among the mortality causes in the Western world, indicating a poor adaptation rate of cardiovascular medicine, albeit
Gatsiou A, Stellos K
openaire +3 more sources
Cracking the epitranscriptome [PDF]
RNA, 2016 Over 100 distinct chemical modifications can be catalyzed on RNA post-synthesis, potentially serving as a post-transcriptional regulatory layer of gene expression. This review focuses on recent advances, knowledge gaps, and challenges pertaining to N6-methyladenosine (m6A), an abundant modification of mRNA for which substantial progress has been made ...
openaire +2 more sources
Epitranscriptomics for Biomedical Discovery [PDF]
, 2017 Epitranscriptomics is a newly burgeoning field pertaining to the complete delineation and elucidation of chemical modifications of nucleotides found within all classes of RNA that do not involve a change in the ribonucleotide sequence.
Heruth, Daniel P. +6 more
core +1 more source
The mammalian mitochondrial epitranscriptome
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019 Correct expression of the mitochondrially-encoded genes is critical for the production of the components of the oxidative phosphorylation machinery. Post-transcriptional modifications of mitochondrial transcripts have been emerging as an important regulatory feature of mitochondrial gene expression.
Rebelo-Guiomar, Pedro +3 more
openaire +3 more sources
Emerging Roles of Long Noncoding RNAs in Breast Cancer Epigenetics and Epitranscriptomics
Frontiers in Cell and Developmental Biology, 2022 Breast carcinogenesis is a multistep process that involves both genetic and epigenetic changes. Epigenetics refers to reversible changes in gene expression that are not accompanied by changes in gene sequence.
Elżbieta Wanowska +3 more
doaj +1 more source
The Epitranscriptome and Innate Immunity [PDF]
PLOS Genetics, 2015 Our knowledge of the variety and abundances of RNA base modifications is rapidly increasing. Modified bases have critical roles in tRNAs, rRNAs, translation, splicing, RNA interference, and other RNA processes, and are now increasingly detected in all types of transcripts.
O'Connell, Mary +2 more
openaire +4 more sources
Significant epitranscriptomes in heterogeneous cancer [PDF]
Cancer Science, 2019 AbstractPrecision medicine places significant emphasis on techniques for the identification of DNA mutations and gene expression by deep sequencing of gene panels to obtain medical data. However, other diverse information that is not easily readable using bioinformatics, including RNA modifications, has emerged as a novel diagnostic and innovative ...
Masamitsu Konno +2 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Gene regulation depends on dynamic and reversibly modifiable biological and chemical information in the epigenome/epitranscriptome. Accumulating evidence suggests that messenger RNAs (mRNAs) are generated in flashing bursts in the cells in a precisely ...
Suresh Kumar, Trilochan Mohapatra
doaj +1 more source