Results 81 to 90 of about 2,699 (211)

Analysis of epitranscriptome for grading of glioma: Multivariate Analysis of RNA Chemistry Marks Uncovers Epitranscriptomics-Based Biomarker Signature for Adult Diffuse Glioma Diagnostics

, 2022
International audienceOne of the main challenges in cancer management relates to the discovery of reliable biomarkers, which could guide decision-making and predict treatment outcome.
Rivals, Eric
core   +1 more source

RNA‐centric world of retroviruses: unravelling the molecular strategies of genomic RNA packaging

Biological Reviews, EarlyView.
ABSTRACT Retroviruses constitute a unique group of RNA viruses that have profoundly influenced both evolutionary trajectories and biomedical research. Their ability to reverse transcribe and integrate into host genomes has shaped genomic architecture across species and contributed to our understanding of oncogenes, gene regulation, and RNA biology ...
Mohammad Abdullah Jehad, Suresha G. Prabhu, Lizna M. Ali, Vineeta N. Pillai, Farah Mustafa, Tahir A. Rizvi   +5 more
wiley   +1 more source

Epitranscriptomics: RNA Modifications in Bacteria and Archaea

, 2018
The increasingly complex functionality of RNA is contrasted by its simple chemical composition. RNA is generally built from only four different nucleotides (adenine, guanine, cytosine, and uracil).
Jäschke, A., Höfer, K.
core   +1 more source

Significant epitranscriptomes in heterogeneous cancer [PDF]

Cancer Science, 2019
AbstractPrecision medicine places significant emphasis on techniques for the identification of DNA mutations and gene expression by deep sequencing of gene panels to obtain medical data. However, other diverse information that is not easily readable using bioinformatics, including RNA modifications, has emerged as a novel diagnostic and innovative ...
Masamitsu Konno, Masateru Taniguchi, Hideshi Ishii   +2 more
openaire   +2 more sources

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Deciphering the epitranscriptome: A green perspective [PDF]

Journal of Integrative Plant Biology, 2016
AbstractThe advent of high‐throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation − the epitranscriptome. With over 100 known RNA modifications, understanding the repertoire of RNA modifications is a huge undertaking.
Burgess, A., David, R., Searle, I.
openaire   +3 more sources

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches

, 2022
Epitranscriptomic features, such as single-base RNA editing, are sources of transcript diversity in cancer, but little is understood in terms of their spatial context in the tumour microenvironment.
Ryu, Han Suk, Kim, Changhoe, Kim, Okju, Lee, Han-Byoel, Cheun, Jong-Ho, Noh, Jinsung, Yoo, Duck Kyun, Kim, Inyoung, Kim, Byung Gee, Lee, Wooseok, Lee, Yongju, Lee, Sangeun, Lee, Yonghee, Kim, Ji Young, Bae, Sangwook, Choi, Ahyoun, Ryu, Seung Yeon, Chung, Junho, Han, Wonshik, Lee, Hyunho, Kwon, Sunghoon, Lee, Sumin, Kim, Jinhyun, Choi, Yeongjae, Song, Seo Woo, Yeom, Huiran, Kim, Hoe Suk, Kim, Namphil, Ryu, Taehoon, Jung, Yushin, Lee, Amos C., Choi, Hansol, Shin, Kyoungseob   +32 more
core   +1 more source

Emerging Role of Environmental Epitranscriptomics and RNA Modifications in Parkinson’s Disease

Journal of Parkinson’s Disease
Environmental risk factors and gene-environment interactions play a critical role in Parkinson’s disease (PD). However, the relatively large contribution of environmental risk factors in the overwhelming majority of PD cases has been widely neglected in ...
John T. Gionco, Alison I. Bernstein
doaj   +1 more source