Results 81 to 90 of about 5,351 (235)

Interplay Between N6-Methyladenosine (m6A) and Non-coding RNAs in Cell Development and Cancer

Frontiers in Cell and Developmental Biology, 2019
RNA chemical modifications in coding and non-coding RNAs have been known for decades. They are generally installed by specific enzymes and, in some cases, can be read and erased by other specific proteins. The impact of RNA chemical modifications on gene
Francesco Fazi, Alessandro Fatica
doaj   +1 more source

Alteration of m6A RNA Methylation in Heart Failure With Preserved Ejection Fraction

Frontiers in Cardiovascular Medicine, 2021
Background: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disease, in which its pathogenesis is very complex and far from defined.
Beijian Zhang, Beijian Zhang, Beijian Zhang, Yamei Xu, Xiaotong Cui, Hao Jiang, Hao Jiang, Hao Jiang, Wei Luo, Wei Luo, Wei Luo, Xinyu Weng, Xinyu Weng, Xinyu Weng, Yun Wang, Yun Wang, Yun Wang, Yun Wang, Yuhong Zhao, Aijun Sun, Aijun Sun, Aijun Sun, Aijun Sun, Junbo Ge, Junbo Ge, Junbo Ge, Junbo Ge   +26 more
doaj   +1 more source

Charting the unknown epitranscriptome

Nature Reviews Molecular Cell Biology, 2017
RNA modifications can alter RNA structure-function relationships and various cellular processes. However, the genomic distribution and biological roles of most RNA modifications remain uncharacterized. Here, we propose using phage display antibody technology and direct sequencing through nanopores to facilitate systematic interrogation of the ...
Novoa Pardo, EM, Mason, CE, Mattick, JS
openaire   +3 more sources

Multivariate Analysis of RNA Chemistry Marks Uncovers Epitranscriptomics-Based Biomarker Signature for Adult Diffuse Glioma Diagnostics

Analytical Chemistry, 2022
One of the main challenges in cancer management relates to the discovery of reliable biomarkers, which could guide decision-making and predict treatment outcome.
S. Relier, A. Amalric, A. Attina, I. B. Koumare, V. Rigau, F. Burel Vandenbos, D. Fontaine, M. Baroncini, J. Hugnot, H. Duffau, L. Bauchet, C. Hirtz, Eric Rivals, A. David   +13 more
semanticscholar   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

How Do You Identify m6 A Methylation in Transcriptomes at High Resolution? A Comparison of Recent Datasets

Frontiers in Genetics, 2020
A flurry of methods has been developed in recent years to identify N6-methyladenosine (m6A) sites across transcriptomes at high resolution. This raises the need to understand both the common features and those that are unique to each method.
Charlotte Capitanchik, Patrick Toolan-Kerr, Patrick Toolan-Kerr, Nicholas M. Luscombe, Nicholas M. Luscombe, Nicholas M. Luscombe, Jernej Ule, Jernej Ule   +7 more
doaj   +1 more source

The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics?

Genes, 2021
RNA modifications, long considered to be molecular curiosities embellishing just abundant and non-coding RNAs, have now moved into the focus of both academic and applied research.
M. Schaefer
semanticscholar   +1 more source

m5C‐Modified tRF3b‐CysGCA‐23 Suppresses Bladder Cancer Malignancy by Repressing H3K18 Lactylation via Stabilizing RBM4

Advanced Science, EarlyView.
In this study, we identified an NSUN6‐dependent m5C‐modified tsRNA, m5C‐tRF3b CysGCA‐23 (mtRC), that is downregulated in BC and inversely correlated with disease progression. Mechanistically, mtRC suppresses BC malignancy by stabilizing RBM4, attenuating glycolysis, and thereby limiting H3K18 lactylation–mediated activation of IL1RAP and VASH2 ...
Xiaoling Ying, Yapeng Huang, Jian Huang, Qinyu Cai, Danni Zhang, Cong Chen, Yuxi Nie, Baotong Yang, Chuan Li, Wenyu Hu, Chang Xiong, Chengcheng Zhang, Ding Ji, Yaomin Liang, Mei Yang, Wenqi Wu, Weidong Ji   +16 more
wiley   +1 more source

Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology

Toxicological Sciences, 2021
Epitranscriptomics, the study of chemically modified RNAs, is a burgeoning field being explored in a variety of scientific disciplines. Of the currently known epitranscriptomic modifications, N6-methyladenosine (m6A) methylation is the most abundant. The
Emir Malovic, Alyssa Ealy, A. Kanthasamy, A. Kanthasamy   +3 more
semanticscholar   +1 more source