Results 81 to 90 of about 3,015 (181)

Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches

, 2022
Epitranscriptomic features, such as single-base RNA editing, are sources of transcript diversity in cancer, but little is understood in terms of their spatial context in the tumour microenvironment.
Ryu, Han Suk, Kim, Changhoe, Kim, Okju, Lee, Han-Byoel, Cheun, Jong-Ho, Noh, Jinsung, Yoo, Duck Kyun, Kim, Inyoung, Kim, Byung Gee, Lee, Wooseok, Lee, Yongju, Lee, Sangeun, Lee, Yonghee, Kim, Ji Young, Bae, Sangwook, Choi, Ahyoun, Ryu, Seung Yeon, Chung, Junho, Han, Wonshik, Lee, Hyunho, Kwon, Sunghoon, Lee, Sumin, Kim, Jinhyun, Choi, Yeongjae, Song, Seo Woo, Yeom, Huiran, Kim, Hoe Suk, Kim, Namphil, Ryu, Taehoon, Jung, Yushin, Lee, Amos C., Choi, Hansol, Shin, Kyoungseob   +32 more
core   +1 more source

Epigenetic regulation in cognitive impairment: Focus on N6‐methyladenosine modification and its potential role in perioperative neurocognitive disorders

Ibrain
N6‐methyladenosine (m6A), the most abundant internal modification in mammalian mRNA, plays a critical role in cognitive function by dynamically regulating gene expression. This narrative review examines m6A's role in cognitive processes and its potential
Ting Liu, Xiao‐Juan Yang, Lin Zhou, Mi Gan, Ting‐Ting He, Sen Hong, Yan‐Yan Feng, Gao Su, You‐Xiao Zhao, Ying Cao, Qing‐Fan Zeng   +10 more
doaj   +1 more source

The novel regulatory influence of Argonaute 1 on messenger RNA 5‐methylcytosine modification in Arabidopsis thaliana

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract 5‐Methylcytidine (m5C) modifications play a critical role in RNA metabolism. TRM4B (tRNA‐specific methytransferase 4B) is the only known component of the plant m5C machinery that mediates mRNA (messenger RNA) methylation. To date, no regulators governing site‐specific m5C modifications have been identified, apart from several degenerated ...
Zedi Feng, Xiu Yin, Zhifang Jiang, Jia Yao, Yiling Dong, Xiaoxia Ma, Yijun Meng   +6 more
wiley   +1 more source

Circular RNAs in Drug‐Induced Cardiotoxicity: Roles, Mechanisms, and Therapeutic Potential

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Circular RNAs have emerged as novel regulators and potential biomarkers in drug‐induced cardiotoxicity. This review summarizes the biogenesis, functional roles, and translational potential of circRNAs in cardiotoxicity assessment and drug safety evaluation.
KeXin Leng, Zixuan Yang, Lei Shi, Zhimin Sun, Mengyun Gu, Naping Tang   +5 more
wiley   +1 more source

Mechanistic link between epitranscriptomics and a key driver of oncogenesis

, 2023
Apart from modifications in DNA and histones, post-transcriptional RNA modifications are also being recognized as the third key aspect of epigenetics.
Ma, Haili
core  

PRAME Augments K63‐Linked Ubiquitination and Stabilization of METTL3 to Promote Lung Adenocarcinoma Metastasis

MedComm, Volume 7, Issue 11, November 2026.
PRAME promotes lung adenocarcinoma metastasis by inducing K63‐linked ubiquitination of METTL3 at lysine 235, thereby enhancing METTL3 stability and m6A methyltransferase complex assembly. Elevated METTL3 activity increases m6A modification of TGFB2 mRNA, leading to activation of TGF‐β signaling and metastatic progression of lung adenocarcinoma (LUAD ...
Xia Yang, Xuemei Xu, Yaxuan Zhang, Jiamei Guo, Zhiyu Ye, Qiaorui Bai, Xiuqiao Yang, Shujun Liang, Xiang Dong, Xin Zhang, Jiyong Gu, Shuqin Dai, Hongchun Du, Meiwan Chen, Tianyu Tao, Hongyu Guan, Jueheng Wu, Han Tian, Junchao Cai, Mengfeng Li, Xu Li, Yi Yang   +21 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Epitranscriptomics in myeloid malignancies

Blood Science, 2022
Li Han, Jianjun Chen, Rui Su
doaj   +1 more source

Targeting the Tumor Microenvironment Network to Overcome Immunotherapy Resistance in Non‐Small Cell Lung Cancer: Mechanisms to Clinical Translation

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Immunotherapy has transformed the treatment landscape for advanced non‐small cell lung cancer (NSCLC), yet resistance mediated by the tumor microenvironment (TME) limits its efficacy in most patients. This review aims to synthesize the current understanding of the TME as an integrated network driving immunotherapy resistance and to ...
Zengrui Wang, Zhuang Luo, Le Wang, Jiefu Tang, Zhi Zhang, Xinli Fan   +5 more
wiley   +1 more source

Emerging role of m6A modification in ovarian cancer: progression, drug resistance, and therapeutic prospects

Frontiers in Oncology
Ovarian Cancer (OC) ranks as a prominent contributor to mortality among female reproductive system associated cancers, particularly the prevalent subtype epithelial Ovarian Cancer (EOC).
Shahil Alam, Pankaj Kumar Giri
doaj   +1 more source