Results 101 to 110 of about 3,015 (181)
Nanopore-m6A-finder, a novel m6A site caller for Nanopore DRS data
Frontiers in GeneticsIntroductionN6-methyladenosine (m6A) is a pivotal RNA modification involved in diverse biological and pathological processes. Compared to the m6A detection methods based on second-generation sequencing, Nanopore direct RNA sequencing (DRS) offers the ...
Yuening Yang +7 more
doaj +1 more source
Polyphenism Through RNA Chemical Modifications
Molecular Ecology, Volume 35, Issue 19, October 2026.ABSTRACT Polyphenism, the capacity of a single genotype to produce discrete phenotypes in response to environmental cues, has long served as a model for understanding developmental plasticity. While classical studies have highlighted hormonal signalling and transcription‐factor‐driven gene regulatory networks that mediate these environmentally induced ...
Ralf Schneider, Ehsan Pashay Ahi
wiley +1 more source
The Emerging Role of Epitranscriptomics in Cancer: Focus on Urological Tumors
, 2018 Epitranscriptomics has gained ground in recent years, especially after the advent of techniques for accurately studying these mechanisms. Among all modifications occurring in RNA molecules, N6-methyladenosine (m6A) is the most frequent, especially among ...
Rui Henrique +3 more
core +1 more source
Frontiers in PharmacologyPsychiatric disorders and several neurodevelopmental conditions, including autism spectrum disorder, display marked sex biases in prevalence, symptom profiles, and treatment response.
Nicolás Palacios-Avendaño +3 more
doaj +1 more source
Problems With GO Enrichment as an Endpoint for Ecological Omics Interpretation
Molecular Ecology, Volume 35, Issue 19, October 2026.ABSTRACT Gene Ontology (GO) enrichment analysis has been widely adopted for interpretating omics data, including in ecological research. Although valuable for summarizing large gene lists into functional categories, it is often treated as the final interpretive step.
Ehsan Pashay Ahi +2 more
wiley +1 more source
Frontiers in Cell and Developmental BiologyReduced oxygen availability is an environmental factor characteristic of high-altitude conditions that plays a critical role in shaping cellular homeostasis and epigenomic regulation.
Marketa Hlavackova +10 more
doaj +1 more source
Annals of the New York Academy of Sciences, Volume 1564, Issue 1, October 2026.Epitranscriptomic marks are highly variable across life stages and tissues, complicating comparisons between species. Using m6A consensus motifs, we developed a genomic indicator reflecting transcript methylability, the DRACH o/e score, that we used to investigate epitranscriptomic features and associated functions across nine bilaterian species.
Natacha Clairet +4 more
wiley +1 more source
Mitochondrial RNA Modifications in Pancreatic β-Cells: A Novel Axis in Early Diabetes Pathogenesis
SciMitochondrial RNA (mtRNA) modifications have emerged as critical regulators of pancreatic β-cell bioenergetics, influencing glucose-stimulated insulin secretion (GSIS) and the early pathogenesis of diabetes mellitus (DM).
Nurfadjriah Fintari Butar Butar +8 more
doaj +1 more source
Cancer Biology & TherapyBladder cancer (BC) remains challenging due to its recurrence and metastasis, with METTL3-mediated m6 A RNA modification emerging as a key oncogenic driver. This review synthesizes METTL3’s roles in BC progression, including tumor initiation, metastasis,
Hua Chun, Kangzhuo Baima
doaj +1 more source
Epigenetics and epitranscriptomics in temporal patterning of cortical neural progenitor competence
, 2018 During embryonic brain development, neural progenitor/stem cells (NPCs) sequentially give rise to different subtypes of neurons and glia via a highly orchestrated process.
Caroline Vissers +3 more
core +1 more source