Results 71 to 80 of about 3,540,807 (288)

Accurate detection of m6A RNA modifications in native RNA sequences

Nature Communications, 2019
The epitranscriptomics field has undergone an enormous expansion in the last few years; however, a major limitation is the lack of generic methods to map RNA modifications transcriptome-wide.
Huanle Liu, Oguzhan Begik, M. Lucas, J. Ramirez, C. Mason, David Wiener, Schraga Schwartz, J. Mattick, Martin A. Smith, E. Novoa   +9 more
semanticscholar   +1 more source

DirectRMDB: a database of post-transcriptional RNA modifications unveiled from direct RNA sequencing technology

Nucleic Acids Res., 2022
With advanced technologies to map RNA modifications, our understanding of them has been revolutionized, and they are seen to be far more widespread and important than previously thought.
Yu-xin Zhang, Jie Jiang, Jiongming Ma, Zhen Wei, Yue Wang, B. Song, Jia Meng, G. Jia, J. P. D. Magalhães, D. Rigden, Daiyun Hang, Kunqi Chen   +11 more
semanticscholar   +1 more source

Elucidating the Functions of Non-Coding RNAs from the Perspective of RNA Modifications

Non-Coding RNA, 2021
It is now commonly accepted that most of the mammalian genome is transcribed as RNA, yet less than 2% of such RNA encode for proteins. A majority of transcribed RNA exists as non-protein-coding RNAs (ncRNAs) with various functions. Because of the lack of
Venkata Naga Srikanth Garikipati, Shizuka Uchida   +1 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

RNA Modification in the Immune System

Annual Review of Immunology, 2023
Characterization of RNA modifications has identified their distribution features and molecular functions. Dynamic changes in RNA modification on various forms of RNA are essential for the development and function of the immune system. In this review, we discuss the value of innovative RNA modification profiling technologies to uncover the function of ...
Dali, Han, Meng Michelle, Xu
openaire   +2 more sources

RNA modifications in plant adaptation to abiotic stresses

Plant Communications
Epitranscriptomic chemical modifications of RNAs have emerged as potent regulatory mechanisms in the process of plant stress adaptation. Currently, over 170 distinct chemical modifications have been identified in mRNAs, tRNAs, rRNAs, microRNAs (miRNAs ...
Jing Cai, Ling X. Shen, Hunseung Kang, Tao Xu   +3 more
semanticscholar   +1 more source

RM2Target: a comprehensive database for targets of writers, erasers and readers of RNA modifications

Nucleic Acids Res., 2022
RNA modification is a dynamic and reversible process regulated by a series of writers, erasers and readers (WERs). Abnormal changes of WERs will disrupt the RNA modification homeostasis of their target genes, leading to the dysregulation of RNA ...
Xiaoqiong Bao, Yin Zhang, Huiqin Li, Yuyan Teng, L. Ma, Zhihang Chen, Xiaotong Luo, Jian Zheng, An Zhao, Jian Ren, Zhixiang Zuo   +10 more
semanticscholar   +1 more source

Transfer RNA modifications and cellular thermotolerance.

Molecules and Cells
RNA molecules are modified post-transcriptionally to acquire their diverse functions. Transfer RNA (tRNA) has the widest variety and largest numbers of RNA modifications.
Takayuki Ohira, Tsutomu Suzuki
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

RNA modification-mediated multidimensional crosstalk: a novel perspective on gene expression regulation

Genome Biology
RNA modifications play pivotal roles in regulating RNA metabolism. Notably, they do not function in isolation, but crosstalk with DNA/protein modifications and other RNA modifications to form multi-layered regulatory networks that cooperatively fine-tune
Yan Wang, Chunxu Yang, Rongjie Lin, Huan Ling, Yong-Zhen Xu, Qiuji Wu, Yunfeng Zhou   +6 more
doaj   +1 more source